为什么是十月怀胎？原来胎盘内有“闹钟”计时！

2016-09-17 徐徐中国科学报

怀孕结束、分娩开始的时刻似乎受到包围胎儿且像时钟一样发挥作用的膜状物的控制。减慢或加快该“时钟”的药物能帮助确保更多婴儿在接近标准的第40周时出生。相关成果日前发表于《人类生殖》杂志。每年全球约有1500万名婴儿早产，即在怀孕的第37周前出生。这些婴儿发育不全的器官使其面临着一系列疾病的威胁，并且有100万名婴儿在1岁生日前死去。早产分别占到英国、美国婴儿死亡数的8%和 11%，使其成为导致婴儿死

怀孕结束、分娩开始的时刻似乎受到包围胎儿且像时钟一样发挥作用的膜状物的控制。减慢或加快该“时钟”的药物能帮助确保更多婴儿在接近标准的第40周时出生。相关成果日前发表于《人类生殖》杂志。

每年全球约有1500万名婴儿早产，即在怀孕的第37周前出生。这些婴儿发育不全的器官使其面临着一系列疾病的威胁，并且有100万名婴儿在1岁生日前死去。早产分别占到英国、美国婴儿死亡数的8%和 11%，使其成为导致婴儿死亡的最大原因。

另一方面，孕期过长也会产生风险。在42周后分娩更有可能出现死胎，而这可能是因为胎盘无法存活足够长的时间，以支撑此时还在发育中的胎儿。“分娩时机极其重要。”来自得克萨斯大学的Ramkumar Menon表示。

Menon和同事通过理解标准的足月分娩如何发生，致力于寻找一种确保婴儿在恰当时刻出生的方法。该团队认为，包围胎儿的膜状物会像闹钟一样发挥作用，在孕期结束和分娩开始时响起。随着胎儿生长，这种液囊会老化。等到婴儿准备出生时，液囊已经老化到开始发炎，并且引发连锁反应。随着炎症从胎囊扩散到女性子宫，引发炎症的化学物质开始造成严重破坏——改变了激素，停止维持妊娠，并且开始引发宫缩。

该想法得到各种证据的支持。从一名自然分娩女性身上取下的胎囊器官，在显微镜下表现出大量的老化迹象。在小鼠身上开展的研究也表明，炎症在孕期结束时加强。

原始出处：

Lim R, Barker G, Menon R, Lappas M. A Novel Role for SIRT3 in Regulating Mediators Involved in the Terminal Pathways of Human Labor and Delivery. Biol Reprod. 2016 Sep 14. pii: biolreprod.116.142372.

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2016-09-27 童小孩

学习了，很受益，谢谢分享，继续关注中！

28 0
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2016-09-25 舒心和人

感谢分享，学习新知识，人体真的很奇妙

0 0
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2016-09-20 1e0c17e7m86(暂无匿称)

好神奇！

37 0
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2016-09-19 liuyong2981

#胎盘#

21 0
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Sep 18 06:45:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129856, encodeId=9556129856ca, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Sep 18 06:44:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129774, encodeId=454b129e74e4, content=很好的内容，继续学习。, 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2016-09-18 qixiaotong123

这种更加细致的研究有利于临床工作

40 0
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Sep 18 06:45:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129856, encodeId=9556129856ca, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Sep 18 06:44:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129774, encodeId=454b129e74e4, content=很好的内容，继续学习。, 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2016-09-18 1e0eef6fm76(暂无匿称)

学习了，赞

43 0
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2016-09-18 1dd8a7c5m95(暂无匿称)

学习了，赞一个！！！

18 0
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2016-09-18 半夏微凉

继续关注

19 0
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2016-09-18 半夏微凉

谢谢分享，学习了

23 0
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2016-09-17 lhl629

很好的内容，继续学习。

24 0