Arch Gynecol Obstet:宫颈癌的预后因子--嗜神经侵袭(PNI)

2015-02-03 MedSci MedSci原创

最近发表的研究表明,嗜神经侵袭(PNI) 可能作为宫颈癌的不良预后因素之一。本文系统的分析了嗜神经侵袭(PNI)对宫颈癌的整体生存率和无病生存率 的影响。 我们基于PubMed和Cochrane clinical trials数据库搜索了截至2013年9月以前的相关研究文章。对宫颈癌根治术+淋巴结切除术后的嗜神经侵袭(PNI)影响的生存分析进行了回顾性研究。 在数据收集与分析中,研究人员基于

最近发表的研究表明,嗜神经侵袭(PNI) 可能作为宫颈癌的不良预后因素之一。本文系统的分析了嗜神经侵袭(PNI)对宫颈癌的整体生存率和无病生存率 的影响。

我们基于PubMed和Cochrane clinical trials数据库搜索了截至2013年9月以前的相关研究文章。对宫颈癌根治术+淋巴结切除术后的嗜神经侵袭(PNI)影响的生存分析进行了回顾性研究。

在数据收集与分析中,研究人员基于 Newcastle-Ottawa scale (NOS)评分单独对试验特征、结果以及质量评估的数据及结果提取,基于分析风险比(HR)对出现嗜神经侵袭的患者整体生存率和无病生存率的结果进行分析。

通过对这些研究的分析得出伴有嗜神经侵袭(PNI)子宫癌患者的整体生存率较低(HR 2.21, 95 % CI 1.36-3.59, P = 0.001。在PNI组,尽管无病生存率相对较低(HR 1.35, 95 % CI 0.78-2.31, P = 0.28), 但是结果并无统计学意义。

结论:在伴有嗜神经侵袭(PNI)子宫癌患者中,整体生存率较低。因此,我们可以得出在宫颈癌中PNI是一个不良预后的影响因子。基于这些研究结果,PNI应该是一个独立的子宫颈癌的预后因素,在术后我们应该进行一些相适应的辅助治疗。

原始出处

Cui L1, Shi Y, Zhang GN.Perineural invasion as a prognostic factor for cervical cancer: a systematic review and meta-analysis.Arch Gynecol Obstet. 2015 Jan 31

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    2015-11-01 yhy100200
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    2015-03-29 lqvr
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    2015-02-05 一闲

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