PLoS One:屋尘螨舌下免疫治疗不能阻止过敏性鼻炎儿童中新过敏原敏感性和支气管高反应性

2017-08-22 AlexYang MedSci原创

最近,有研究人员通过长期的群体跟踪调查研究,进行了旨在鉴定舌下免疫治疗(SLIT)对免疫学参数和支气管高反应性的影响,研究群体为患有对屋尘螨过敏的过敏性鼻炎儿童。在儿童过敏性鼻炎群体研究中,研究人员研究了在医院询问鼻炎症状并且通过皮刺试验证明为对HDM过敏的儿科病人。在该群体中,37名病人接受了超过3年的SLIT治疗(SLIT组),184名病人只接受了药物治疗(非SLIT组)。研究人员对两个小组在

最近,有研究人员通过长期的群体跟踪调查研究,进行了旨在鉴定舌下免疫治疗(SLIT)对免疫学参数和支气管高反应性的影响,研究群体为患有对屋尘螨过敏的过敏性鼻炎儿童

儿童过敏性鼻炎群体研究中,研究人员研究了在医院询问鼻炎症状并且通过皮刺试验证明为对HDM过敏的儿科病人。在该群体中,37名病人接受了超过3年的SLIT治疗(SLIT组),184名病人只接受了药物治疗(非SLIT组)。研究人员对两个小组在起始和3年跟踪调查后的皮刺试验、嗜酸性粒细胞百分比和计数、总免疫球蛋白E(lgE)和支气管激发试验结果进行了比较。

研究发现,在3年的跟踪调查后,只有嗜酸性粒细胞比例减少在SLIT组中要比非SLIT组更显著。除了HDM的新敏感化比例在SLIT和非SLIT组中没有表现出任何的显著差异。除了HDM的敏感的过敏原分布在两个小组中表明了增长的形势。不考虑SLIT,较大的年龄和少数敏感过敏原影响了支气管高反应性的改善。最后,研究人员指出,HDM SLIT在韩国过敏性鼻炎儿童的3年调查期间并没有影响新敏感的阻止、多敏感比例的增加和支气管高反应性的改善。

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createdName=12499e01m47暂无昵称, createdTime=Wed Apr 18 12:40:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1790027, encodeId=45491e90027e3, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sat Mar 17 05:40:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892104, encodeId=e4ca1892104c1, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Sat Dec 16 09:40:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237396, encodeId=6b1f23e396dc, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sat Aug 26 14:36:33 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237395, encodeId=cbd923e395ba, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sat Aug 26 14:36:28 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348574, encodeId=7cc413485e45d, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Thu Aug 24 10:40:00 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388372, encodeId=0c6213883e22f, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, 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objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Tue Aug 22 22:55:09 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2046871, encodeId=205420468e1b6, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Tue Jan 02 15:40:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022793, encodeId=c3b42022e932c, content=<a href='/topic/show?id=188b3e7309c' target=_blank style='color:#2F92EE;'>#反应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37730, encryptionId=188b3e7309c, topicName=反应性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, 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encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Sat Dec 16 09:40:00 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237396, encodeId=6b1f23e396dc, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sat Aug 26 14:36:33 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237395, encodeId=cbd923e395ba, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Sat Aug 26 14:36:28 CST 2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348574, encodeId=7cc413485e45d, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Thu Aug 24 10:40:00 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388372, encodeId=0c6213883e22f, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJnkE6UvGFfMS41qV0RicWvVTTeLMicqibeZH5GqO4YhNicyl1Y9jFhylIUBn9ntPYy9jhk5hrfic5cRYw/132, createdBy=5f822500020, createdName=ms5236388012055669, createdTime=Thu Aug 24 10:40:00 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442611, encodeId=2b3a14426110d, content=<a href='/topic/show?id=625194032a5' target=_blank style='color:#2F92EE;'>#过敏原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94032, encryptionId=625194032a5, topicName=过敏原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=81884942400, createdName=12498cb5m14暂无昵称, createdTime=Thu Aug 24 10:40:00 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236133, encodeId=1adc23613371, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Tue Aug 22 22:55:09 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-26 往日如昨

    继续学习中谢谢

    0

  6. 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2017, time=2017-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348574, encodeId=7cc413485e45d, content=<a href='/topic/show?id=54c24e71237' target=_blank style='color:#2F92EE;'>#屋尘螨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47712, encryptionId=54c24e71237, topicName=屋尘螨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Thu Aug 24 10:40:00 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388372, encodeId=0c6213883e22f, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, 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objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Tue Aug 22 22:55:09 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-26 往日如昨

    学习了谢谢分享

    0

  7. 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    2017-08-22 184****9840

    学习了受益匪浅

    0

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鼻纤维素粉(NCP)可以阻止过敏原结合到鼻粘膜,从而可以减少尘螨敏感儿童过敏性鼻炎(AR)症状的发生。最近,有研究人员评估了NCP在鼻气流限制临床症状改善中的功效和鼻腔炎症细胞中的响应。研究招募了年龄在6-18岁的且患有尘螨敏感过敏性鼻炎的儿童。在4周磨合期结束后,研究人员进行了NCP或者安慰剂处理,1个鼻孔喷一次,一天3次,持续时间为4周。屋尘螨(Der p)鼻黏膜激发试验(NPT)在处理前后分

Rhinology:在一个过敏性鼻炎小鼠模型中,过敏性炎症可以被过敏原诱导的类型2固有淋巴细胞加重

类型2固有淋巴细胞(ILC2s)代表了一种新的先天性效应白细胞类群,并且可以调节类型2免疫响应。然而,ILC2s对过敏性鼻炎(AR)的作用到目前为止仍旧还未鉴定。为了评估过敏原诱导的ILC2s在实验性AR中潜在的存在和作用,研究人员利用卵清蛋白(OVA)和氢氧化铝建立了一个AR小鼠模型,并从小鼠鼻相关淋巴组织(NALT)中筛选和纯化OVA诱导的ILC2s。然后,研究人员评估了在细胞培养中评估了IL

PLoS One:患有过敏性鼻炎的病人,牙外伤风险增加

过敏性鼻炎(AR)与影响牙齿的各种发展问题相关。最近,有研究人员调查了在台湾地区人口中,是否AR与牙外伤(TDIs)风险的增加相关。研究人员利用台湾地区医疗健康研究数据库(NHIRD)进行了一项巢式病例对照研究。他们比较了患有过敏性鼻炎人群和与之匹配的不患有过敏性鼻炎人群的相关参数。在研究中,他们还确定了新的TDI病例。为了比较TDI在研究群体中的风险,研究人员利用Cox比例回归分析和风险比(HR

Allergy Asthma Clin Immunol: 不良睡眠与屋尘螨过敏性鼻炎高度相关

睡眠障碍在患有过敏症病人中常见报道。最近,有研究人员鉴定了睡眠障碍与屋尘螨(HDM)呼吸道过敏原在常规临床实践的舌下过敏原免疫疗法(SLIT)起始时的关系。研究人员设计的研究为前瞻性的、代表性的和观察性的研究,时间在2014年11月到2015年3月,地点在189个法国试验地点,总共包括了1750名HDM过敏的且开始SLIT治疗的病人,排除了年龄小于5岁的和之前进行过HDM过敏原抗原免疫治疗(AIT

Am J Rhinol Allergy:过敏性鼻炎的症状与减少的健康生活品质的关系

目前,特异性的过敏性鼻炎症状对病人生活品质(QOL)的影响仍旧未知。最近,有研究人员探究了过敏性鼻炎鼻骨和鼻外症状对健康相关的QOL的关系。该横断面研究总共包括了150名年龄大于18岁的参与者,并且这些参与者患有永久性过敏性鼻炎。健康相关的QOL通过利用来自5维EuroQol QOL调查(EO-5D)的视觉模拟量表(VAS)来进行测量。利用22项中鼻结果测试(SNOT-22)来对鼻骨和鼻外症状的严