JGH OPEN:内镜下粘膜剥离术对浅表食管癌局部复发风险的影响

2020-04-12 MedSci原创 MedSci原创

内窥镜下黏膜下层剥离术(ESD)早期食管癌的治疗效果目前还有争论。因此,本项研究旨在对其进行相关研究。

背景与目标:内窥镜下黏膜下层剥离术(ESD)早期食管癌的治疗效果目前还有争论。因此,本项研究旨在对其进行相关研究。

方法:这项单中心回顾性研究是在日本国际癌症研究所进行的。根据以下纳入标准,研究人员对在2005年4月到2015年6月间的749例患者,共886次食管鳞状细胞癌病变进行评价:整块切除无残留病变,同时进一步根据癌症与标本边缘之间的距离切下来的组织进行了分类:B1型,<1 mm,B2型,≥1mm。

结果:在39个病变中,有30个符合纳入标准。30处病变中有8处发生局部复发(26.7%)。A,B1和B2型的局部复发率分别为40%(6/15个病变),28.5%(2/7个病变)和0.0%(0/8个病变)。

结论:本项研究表明,行ESD的患者病理组织边缘有癌症细胞是局部复发的有用预测指标。

原始出处:

Hiromu Fukuda. Et al. Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer.journal of gastroenterology and hepatology.2020.

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    2020-08-28 feather89
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    2020-09-21 guoyibin
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    2020-04-14 chg122
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    2020-04-14 zhouqu_8

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复发难治套细胞淋巴瘤MCL治疗安全有效

套细胞淋巴瘤(MCL)是侵袭性B细胞非霍奇金淋巴瘤(NHL),标准治疗结果并不令人满意。Bruton酪氨酸激酶(BTK)抑制剂在多个NHL亚型的治疗作用已得到验证。伊布替尼是第一个BTK抑制剂,经FDA批准用于治疗复发难治(R/R)MCL,尽管疗效令人鼓舞,但患者经常出现腹泻、出血和房颤等不良事件。目前认为非特异性的靶选择性(对EGFR、TEC、BMX等的抑制作用)可能与不良事件相关。因此不断尝试

Ann Rheum Dis:疾病临床静止超过1年的SLE患者是否应停用低剂量泼尼松?

非活动性的SLE患者长期维持5mg泼尼松治疗可以预防复发。

Prostate Cancer P D:生化复发前列腺癌中单胺氧化酶抑制剂phenelzine的2期试验研究

在预临床模型中,单胺氧化酶A(MAOA)能够影响前列腺癌的生长和转移。最近,有研究人员调查了phenelzine(一种单胺氧化酶抑制剂)在生化复发去势敏感性前列腺癌患者中的效果情况。