胃肠胰神经内分泌肿瘤的诊断技术进展

2011-07-29 王春晖 中国医学论坛报

王春晖  医学博士,四川大学华西医院副教授,硕士生导师。长期从事胃肠激素与消化道肿瘤研究,2009年赴美国亚利桑那大学医学中心作访问学者1年。此外,还担任中华医学会消化分会青年委员,四川省医学会消化专业委员会常委,《华西医学》杂志编委。   胃肠胰神经内分泌肿瘤(GEP- NET)是起源于弥散神经系统的一类相对少见的肿瘤。由于其发病率较低,一直未受到广泛关注。过去几十年,由于病理诊断技

王春晖  医学博士,四川大学华西医院副教授,硕士生导师。长期从事胃肠激素与消化道肿瘤研究,2009年赴美国亚利桑那大学医学中心作访问学者1年。此外,还担任中华医学会消化分会青年委员,四川省医学会消化专业委员会常委,《华西医学》杂志编委。   胃肠胰神经内分泌肿瘤(GEP- NET)是起源于弥散神经系统的一类相对少见的肿瘤。由于其发病率较低,一直未受到广泛关注。过去几十年,由于病理诊断技术、内镜技术及影像学技术的发展,这类肿瘤的诊断率有了明显的提高。胃肠胰神经内分泌肿瘤的诊断主要基于临床症状、激素水平、各种影像学检查以及病理学检查。但由于绝大多数胃肠胰神经内分泌肿瘤的临床表现缺乏特异性,早期诊断比较困难。   生化和组织标志物 胃肠胰神经内分泌肿瘤的标志物检测   共同标志物   除临床表现和病理特征外,GEP-NET的诊断非常倚重其生化标志物。一些标志物只在某些特殊类型肿瘤中表达,而另一些标志物如嗜铬粒蛋白 A(Chromogranin A,CgA)、5-羟基吲哚乙酸(5-HIAA)这些最常用的生物指标等则为GEP-NET 的共同标志物。   CgA是许多

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    2012-03-04 gwc392
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唐承薇  医学博士、教授、博士生导师。现任四川大学华西医院消化内科及消化内镜中心主任、人类疾病相关多肽研究室主任,兼任中国医师协会消化医师分会副会长,中华医学会消化专委会常委,四川省医学会消化专委会主任委员。   胃肠胰神经内分泌肿瘤(gastrointestinal pancreatic neuroendocrinetumor,GEP-NET)是一组起源于胃肠道及