Clinica Chimica Acta:血清P物质作为急性自发性脑出血中功能结果的有利生物标志物的潜在作用

2020-08-09 MedSci原创 MedSci原创

P物质(SP)与脑炎症有关。我们明确了血清SP浓度与急性脑出血(ICH)功能结局的关系。

P物质(SP)与脑炎症有关。我们明确了血清SP浓度与急性脑出血(ICH)功能结局的关系。

本研究量化了106例ICH患者的入院血清SP浓度。主要的结果测量是发病后90天(改良Rankin量表评分≥3)的不良结果。与其他患者相比,结果较差的患者血清SP浓度明显较高。血清SP浓度用于鉴别不良结果的曲线下面积为0.795 (95% CI, 0.706至0.867)。血清SP浓度>449 pg/ml预测不良结局的风险,敏感性为63.0%,特异性为78.9%,与不良结局独立相关(优势比5.437;95% CI 2.156至13.715)。血清SP浓度、美国国立卫生研究院中风量表评分(r = 0.480)、血肿体积(r = 0.464)和血清c -反应蛋白浓度(r = 0.398)之间存在正相关。

研究结果表明,脑出血急性期血清SP浓度升高与炎症反应加重、病情加重和功能不良风险增加密切相关,提示血清SP可能是脑出血的炎症预后因素。

原始出处:

Gang Wang,Chen-Jun He,Potential role of serum substance P as a favorable biomarker of functional outcome in acute spontaneous intracerebral hemorrhage

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    2020-12-20 windight
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