IBD: 人疱疹病毒感染是溃疡性结肠炎行结肠切除术的危险因素

2018-06-03 MedSci MedSci原创

对于炎症性肠病(IBD)患者,我们对其患有除巨细胞病毒(CMV)以外的人类疱疹病毒的流行和致病性知之甚少。本研究的目的是确定人类疱疹病毒在IBD患者结肠黏膜中的流行情况,并评估这些患者的长期预后。

背景
对于炎症性肠病IBD)患者,我们对其患有除巨细胞病毒(CMV)以外的人类疱疹病毒的流行和致病性知之甚少。本研究的目的是确定人类疱疹病毒在IBD患者结肠黏膜中的流行情况,并评估这些患者的长期预后。

方法
我们使用多重聚合酶链式反应(PCR)技术检查了66名患有溃疡性结肠炎(UC),54名克罗恩病(CD)患者和29名健康患者的结肠粘膜标本,以鉴定6种最常见类型的人疱疹病毒。

结果
单纯疱疹病毒(HSV)-1/2和水痘 - 带状疱疹病毒(VZV)未在任何组中检测到。在UC患者中EB病毒(EBV)(21.2%)和CMV(15.1%)的患病率高于CD患者(EBV 9.3%,CMV 0%)和健康对照组(EBV 0%,CMV 3.4%)。人类疱疹病毒(HHV)-6A / B和HHV-7的发病率在各组之间没有统计学差异。五名炎症性UC患者共存CMV和EBV或HHV-6。CMV与EBV或HHV-6的联合感染是UC患者随后结肠切除术的显着和独立的预后因素。

结论
伴有EBV / HHV-6感染的CMV患病率增加与UC患者的临床病程有关。

原始出处:

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    2018-10-26 nymo
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    2018-06-05 bnurmamat
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    2018-06-05 heli0118
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    2018-06-03 惠映实验室

    学习了.谢谢分享.

    0

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