宝宝发热,务必警惕急性化脓性脑膜炎!

2017-12-18 MedSci MedSci原创

急性化脓性脑膜炎又称脑膜炎,是化脓性细菌所致的软脑膜、蛛网膜、脑脊液及脑室的急性炎症反应,脑及脊髓表面可轻度受累,常与化脓性脑炎或脑脓肿同时存在。化脓性脑膜炎是一种严重的颅内感染,尽管抗生素的研制已经有了很大进步,但至今急性化脓性脑膜炎的病死率和病残率仍然较高。 病史: 患儿女,2岁,平素体健,偶有感冒。3天前无明显诱因下出现发热,体温在38.5~39.8℃,有寒战,阵发性尖声哭叫

急性化脓性脑膜炎又称脑膜炎,是化脓性细菌所致的软脑膜、蛛网膜、脑脊液及脑室的急性炎症反应,脑及脊髓表面可轻度受累,常与化脓性脑炎或脑脓肿同时存在。化脓性脑膜炎是一种严重的颅内感染,尽管抗生素的研制已经有了很大进步,但至今急性化脓性脑膜炎的病死率和病残率仍然较高。

病史

患儿女,2岁,平素体健,偶有感冒。3天前无明显诱因下出现发热,体温在38.5~39.8℃,有寒战,阵发性尖声哭叫,有时用手捶打头部,频繁呕吐,每日4~6次不等,喷射性,量约50-200毫升,轻咳,流涕。

在外院按“上呼吸道感染”予口服“阿莫西林”2天,效果不佳,发热及其他症状未见明显好转,18小时前、2小时前、10分钟前突发惊厥3次,均表现为呼之不应,双眼凝视,四肢强直,口吐沫,面色青紫,无二便失禁,每次持续约10~15分钟,予按压人中,静推安定等可缓解,缓解后嗜睡。为求进一步治疗,送来我院,患儿发病以来,精神弱、纳差,无皮疹,无腹痛、腹泻,二便正常。

查体

患儿一般情况差,精神弱,嗜睡状,发育正常,无皮疹,咽充血,双扁桃体Ⅱ度肿大,颈抵抗(+),双肺呼吸音粗,未闻啰音,心率:140次/分,律齐,心音有力,肝肋下1.5厘米,质软,脾未及。四肢肌张力正常,双下肢无水肿。神经查体:Brudzinski征(-),Kernig征(-),右侧Babinski(+)。

辅助检查:

头颅CT符合急性化脓性脑膜炎

心电图大致正常心电图

血常规WBC:18.2×109/L,N:70%,L:30%Hb:115g/LPLT:15×109/L

脑脊液检查:压力:2.3Kpa,外观:稍浊,WBC:658×106/L,N:63%,L:37%,pro:6g/L,Glu:1.7mmol/L

结核菌素试验阴性

血培养未见细菌生长

脑脊液培养+药敏未见异常

简要解析:

本病多呈暴发性或急性起病。成人与儿童急性期常表现为发热、剧烈头痛、呕吐、全身抽搐、意识障碍或颈项强直等。病前可有上呼吸道感染史。新生儿与婴儿常有高热、易激惹、嗜睡、呼吸困难、黄疸等,进而可有抽搐、角弓反张及呼吸暂停等,而神经系统表现甚少。新生儿病前可有早产、产伤或产前母亲感染史。体检早期可出现脑膜刺激征,如颈项发硬,Kernig征阳性、Brudzinski征阳性。但婴幼儿颈强直常不明显,常表现为前囟饱满,角弓反张。肺炎球菌和流感嗜血杆菌感染可在早期出现局部脑体征,表现为持续性脑局部损害和难以控制的痫性发作。病程稍晚可有脑神经障碍,以眼球运动障碍多见,在肺炎球菌脑膜炎的患者中发生率最高。另外可有意识障碍及眼底水肿,由于颅内压增高有时可致脑疝形成。在脑膜炎流行期间,如病程进展快,起病时伴有皮肤黏膜淤点或淤斑,并迅速扩大,且发生休克,应考虑脑膜炎球菌脑膜炎。

完整病例请前往【梅斯医生】→病例库→儿科→“发热、呕吐3天,惊厥3次

更多点评分析,趣味的学习,详情尽在梅斯医生上,您可以在这里体验模拟诊疗


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  2. [GetPortalCommentsPageByObjectIdResponse(id=1748168, encodeId=409a1e4816850, content=<a href='/topic/show?id=129533595e9' target=_blank style='color:#2F92EE;'>#化脓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33595, encryptionId=129533595e9, topicName=化脓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=443536086917, createdName=hb2020ye, createdTime=Sun May 06 13:26:00 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270674, encodeId=89762e06745e, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Tue Dec 19 18:45:15 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270540, encodeId=92232e05400f, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Dec 19 08:44:43 CST 2017, time=2017-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270401, encodeId=f4712e04018c, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Mon Dec 18 21:08:15 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270373, encodeId=819a2e037378, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Dec 18 18:44:09 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249817, encodeId=d492124981ef9, content=<a href='/topic/show?id=95264599452' target=_blank style='color:#2F92EE;'>#宝宝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45994, encryptionId=95264599452, topicName=宝宝)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=杏林小小, createdTime=Mon Dec 18 18:26:00 CST 2017, time=2017-12-18, status=1, ipAttribution=)]
    2017-12-19 戒馋,懒,贪

    谢谢分享学习了

    0

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    2017-12-19 jihuaijun1112

    学习学习学习

    0

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    2017-12-18 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

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    2017-12-18 131****1460

    学习了受益匪浅

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