JAHA:出生体重与成人2型糖尿病、心血管疾病和高血压的风险

2018-11-29 xing.T MedSci原创

由此可见,这些研究结果表明出生体重与T2DM和CVD风险呈J型相关,并且这在女性中更为明显。

低出生体重与2型糖尿病(T2DM)、血管疾病和高血压的风险增加有关,但较高出生体重与这些疾病风险之间的关系仍然不确定。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该系统评价和荟萃分析旨在阐明出生体重与成人上述疾病之间的关联方式,并评估性别特异性风险。
 
研究人员系统地检索了PubMed、EMBASE和Web of Science数据库,查找了1980年至2016年10月期间发表的,且包含出生体重和T2DM、心血管疾病(CVD)和高血压的研究。随机效应模型用于推导总结相对风险和相应的95%置信区间。
 
研究人员确定了包含4053367名参与者且评估出生体重与T2DM之间关系的49项研究,其中,33项研究5949477名参与者对CVD、53项研究4335149名参与者对高血压进行了分析。性别特异性二元分析显示只有出生体重分布处于上尾部的女性患T2DM和CVD的风险增加。虽然6个出生体重组和剂量反应分析的分组分析显示出生体重与T2DM和CVD之间的J形关联,但这种关联与高血压相反。T2DM、CVD和高血压的最低风险组分别为3.5-4.0、4.0-4.5和4.0-4.5kg组。
 
由此可见,这些研究结果表明出生体重与T2DM和CVD风险呈J型相关,并且这在女性中更为明显。
 
原始出处:
 

Marianne Ravn Knop.et al.Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta‐Analysis of 7 646 267 Participants From 135 Studies.JAHA.2018. https://www.ahajournals.org/doi/full/10.1161/JAHA.118.008870

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    2019-02-20 13718711b3m

    非常实用的临床经验,值得借鉴的学习资料,学习了,受益匪浅,感谢分享!

    0

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    2019-01-20 13718711b3m

    学习了,非常不错的临床经验,很棒的学习资料,获益匪浅,感谢分享!

    0

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    2018-12-01 zhaohui6731
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    2018-11-29 misszhang

    谢谢MedSci提供最新的资讯

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