Environ Res:空气污染与缺血性卒中相关存在种族差异

2015-10-19 phylis 译 MedSci原创

目的:为了调查空气污染(PM2.5和臭氧)短期改变与有住在一个具有两个种族的地方的人群发生缺血性卒中的风险相关性,评估是否这种相关有种族差异。方法:研究者2000年到2012期间的BASIC计划中识别缺血性卒中的患者。测量同一天或者滞后1-3天的PM2.5(24h)和臭氧(8h最大值)的水平,并且应用条件Logistic回归中时间分层交叉设计模型评估环境污染和急性缺血性卒中发生的相关性。研究者探究

目的:为了调查空气污染(PM2.5和臭氧)短期改变与有住在一个具有两个种族的地方的人群发生缺血性卒中的风险相关性,评估这种相关是否有种族差异。

方法:研究者2000年到2012期间的BASIC计划中识别缺血性卒中的患者。测量同一天或者滞后1-3天的PM2.5(24h)和臭氧(8h最大值)的水平,并且应用条件Logistic回归中时间分层交叉设计模型评估环境污染和急性缺血性卒中发生的相关性。研究者探究模型中种族(墨西哥美国人和非西班牙白人)的不同,以及相关性是否有差异。

结果:共有2948名缺血性卒中患者。年龄的中位数为71岁(IQR:59-80岁)。研究者发现在环境污染和缺血性卒中发生之间没有整体相关性。对种族进行分层分析:高臭氧含量与非西班牙白人发生缺血性卒中可能增加相关,但是与墨西哥美国人无关。高PM2.5与非西班牙白人发生缺血性卒中可能下降相关,但是与墨西哥美国人发生缺血性卒中可能轻度升高相关。

结论:缺血性卒中和短期暴露在臭氧和PM2.5中相关性存在种族差异,这也提示需要进一步研究其他不同种族人群的相关性。

原文出处:

Wing JJ, Adar SD, Sánchez BN,et al.Ethnic differences in ambient air pollution and risk of acute ischemic stroke.Environ Res. 2015 Oct 6.


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    2015-10-21 july_979

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