J Neuropsychology:老年痴呆早期诊断的关键点

2015-06-30 佚名 生物谷

老年痴呆的早期诊断是很不容易的,因为需要与很多其他形式的痴呆症状相鉴别。然而,在老年痴呆早期的患者,往往有两种常见的症状,即记忆困难及理解和语言表达障碍。为了更好地了解清楚,为什么老年痴呆患者早期出现了识别和理解词语的障碍,研究人员们发明了一种测试,可以帮助临床医生们做出早期诊断。来自西班牙York和Oviedo大学的学者们研究了在老年痴呆症早期的患者是否丧失了识别词语的能力,如果答案为"是",那

老年痴呆的早期诊断是很不容易的,因为需要与很多其他形式的痴呆症状相鉴别。然而,在老年痴呆早期的患者,往往有两种常见的症状,即记忆困难及理解和语言表达障碍。为了更好地了解清楚,为什么老年痴呆患者早期出现了识别和理解词语的障碍,研究人员们发明了一种测试,可以帮助临床医生们做出早期诊断。

来自西班牙York和Oviedo大学的学者们研究了在老年痴呆症早期的患者是否丧失了识别词语的能力,如果答案为"是",那么,什么样的词语容易或者是不容易被患者识别。这项研究在西班牙北部的Cabue?es医院开展,且研究结果于近日在线发表在《Journal of Neuropsychology》上。

研究人员们在电脑屏幕上显示出一些真实存在的词语和一些编造出的词语,然后要求参与者们选出那些真正存在的词语。每一道测试为,一个真正存在的词语和3个编造的词语混在一起。在这项测试中的语言为西班牙语,但举一个英语的例子,即从EAGLE,SLINT, OMPUL和CROOM中,将EAGLE选出来。研究人员们用于测试的词语均为健康老年人认识的词语。而且,参与者们选出词语即可,他们不需要说出这些词语的意思。

40名年龄在66到91岁的轻中度老年痴呆患者,及25名健康的人群参加了这项测试,而且患者与健康对照组的年龄,性别,受教育程度都基本相当。结果显示,健康对照组可以毫不费力地选出真正存在的词语,然而,患者组每5个里面就有1个是选择错误的。当研究人员分析了测试结果,他们发现一些词语是患者容易识别出的,而另一些对患者来说,是有困难的。其中,常见词语比较容易选择,有具体意思的词语比抽象意义的词语容易选择,以及幼年学的词语比成年时期学的词语容易识别。而词语的长度对测试结果没有影响。

这项研究的目的是让人们更好地了解老年痴呆症对语言能力的影响,同时,对临床医生用于患者痴呆症状的评估也有潜在的价值。

原始出处:

Fernando Cuetos, Noemí Arce1, Carmen Martínez,Andrew W. Ellis.Word recognition in Alzheimer's disease: Effects of semantic degeneration.Journal of Neuropsychology.June 24,2015

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    2015-07-05 qing1231990

    如果转换成中文的词语会是什么样的后果,有哪些词语比较容易选择

    0

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    2015-07-04 huaxipanxing

    看看

    0

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近日,一项发表于国际著名杂志Nature Structural and Molecular Biology上的研究论文中,来自伊利诺伊大学的科学家们通过研究确定了一种存在于大脑斑块细纤维中的特殊分子结构,该分子结构或是阿尔兹海默氏症发病的标志,这种分子名为β淀粉样蛋白-42,其对神经细胞具有毒性,而且被认为可以刺激疾病的级联反应。 理解纤维中β淀粉样蛋白-42的氨基酸长链形式的物质结构,对于揭示