Heart:碳水化合物和饱和脂肪摄入量与心血管疾病和死亡率的关系

2022-05-10 MedSci原创 MedSci原创

适度的碳水化合物摄入(TEI为41.0%-44.3%)与最低的心血管疾病风险相关,但对总死亡率没有影响。增加饱和脂肪摄入量与心血管疾病或死亡率无关,相反,与较低的糖尿病、高血压和肥胖的发病率相关。

血管疾病是妇女死亡的主要原因。饮食本身既是心血管疾病的风险因素,也会增加中间危险因素的风险,如肥胖、糖尿病(DM)、高血压和血脂异常。然而,关于预防心血管疾病的最佳饮食仍存在争议。也有大量研究报道围绕膳食中宏量营养素(脂肪、碳水化合物和蛋白质)摄入对心血管疾病(CVD)的影响存在相互矛盾,特别是对女性的影响。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,该研究将50~55岁的女性纳入了“澳大利亚妇女健康纵向研究”。

根据碳水化合物和饱和脂肪摄入量占总能量摄入的百分比(TEI),受试者根据五分位数进行了等份。该研究的主要终点为新发心血管疾病(心脏病/卒中),次要终点包括全因死亡率、高血压、肥胖和/或糖尿病。多因素logistic回归模型评估了主要和次要终点的相关性,并对混杂因素进行了调整。

该研究共有9899名女性(平均年龄为52.5±1.5岁)接受了15年的随访,其中1199例患者发生了心血管疾病,470例死亡。在多变量分析中,较高的碳水化合物摄入量与较低的CVD风险相关(趋势p<0.01),与五分位数的第1组(以碳水化合物为能量占比<37.1%)相比,第3组(以碳水化合物为能量占41.0%-44.3%)的CVD风险最低(OR为0.56, 95%CI为0.35-0.91, p=0.02)。碳水化合物摄入量与死亡率(趋势p=0.69)、饱和脂肪摄入量与心血管疾病(趋势p=0.29)或死亡率(趋势p=0.25)之间均无显著相关性。饱和脂肪和碳水化合物摄入量的增加均与高血压、糖尿病和肥胖呈显著负相关(所有P<0.01)。

由此可见,在澳大利亚中年妇女中,适度的碳水化合物摄入(TEI为41.0%-44.3%)与最低的心血管疾病风险相关,但对总死亡率没有影响。增加饱和脂肪摄入量与心血管疾病或死亡率无关,相反,与较低的糖尿病、高血压和肥胖的发病率相关。

原始出处:

Sarah Gribbin.et al.Association of carbohydrate and saturated fat intake with cardiovascular disease and mortality in Australian women.heart.2022.https://heart.bmj.com/content/early/2022/04/25/heartjnl-2021-319654

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    2022-12-14 lmm397
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    2022-05-12 zhaojie88
  4. [GetPortalCommentsPageByObjectIdResponse(id=1860733, encodeId=8d121860e3362, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Wed Dec 14 14:31:18 CST 2022, time=2022-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1906473, encodeId=661819064e348, content=<a href='/topic/show?id=7795334e220' target=_blank style='color:#2F92EE;'>#化合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33472, encryptionId=7795334e220, topicName=化合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Jun 28 19:31:18 CST 2022, time=2022-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357914, encodeId=18ec135e914ce, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu May 12 02:31:18 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464405, encodeId=4727146440523, content=<a href='/topic/show?id=9b04641580e' target=_blank style='color:#2F92EE;'>#水化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64158, encryptionId=9b04641580e, topicName=水化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f1276671681, createdName=yuanming9, createdTime=Thu May 12 02:31:18 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1499064, encodeId=8a2f149906476, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu May 12 02:31:18 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563608, encodeId=03d4156360828, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu May 12 02:31:18 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580028, encodeId=f0bb1580028a8, content=<a href='/topic/show?id=65f0101268d6' target=_blank style='color:#2F92EE;'>#饱和脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101268, encryptionId=65f0101268d6, topicName=饱和脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0db16571375, createdName=斯嘉莉, createdTime=Thu May 12 02:31:18 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596772, encodeId=7f121596e729d, content=<a href='/topic/show?id=90e98435334' target=_blank style='color:#2F92EE;'>#脂肪摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84353, encryptionId=90e98435334, topicName=脂肪摄入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=406418414194, createdName=wumeihua94, createdTime=Thu May 12 02:31:18 CST 2022, time=2022-05-12, status=1, ipAttribution=)]
    2022-05-12 yuanming9
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    2022-05-12 slcumt
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