JCEM:2型糖尿病患者适度低碳水化合物饮食与死亡率的关系

2022-04-20 MedSci原创 MedSci原创

健康的低碳水化合物饮食评分与T2D成人死亡率降低显著相关。坚持均衡适度的低碳水化合物饮食,强调了健康的碳水化合物、植物性蛋白质和多不饱和脂肪,可防止T2D患者过早死亡。

糖尿病是一个与高发病率和死亡率相关的严重公共卫生问题。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在探究不同类型的低碳水化合物饮食与2型糖尿病(T2D)患者死亡率之间的关系。

该前瞻性研究纳入了5677例T2D患者。总体、不健康和健康的低碳水化合物饮食评分是根据碳水化合物、蛋白质和脂肪的总类型和子类型的能量百分比计算出来的。死亡是通过与2015年12月31日之前的国家死亡指数记录联系来确定的。Cox比例风险模型用于估计死亡率的风险比(HRs)和95%置信区间(CIs)。

在中位6.3年的随访期间(39401人次每年),研究人员共记录了1432例死亡。在包括生活方式因素、糖尿病病程和糖化血红蛋白A1c在内的多变量调整后,总体低碳水化合物饮食评分第3个三分位的患者与第1个三分位相比,死亡率风险最低(风险比为0.65[95%可信区间为0.50,0.85])。健康低碳水化合物饮食评分四分位数的多变量调整死亡率HRs (95%CI)分别为1.00(参考值)、0.78(0.64,0.96)、0.73(0.58,0.91)和0.74 (0.58,0.95)(趋势P=0.01)。用植物性蛋白质或多不饱和脂肪酸等热量替代碳水化合物中2%的能量,可使总死亡率降低23%~37%。当按年龄、性别、种族/民族、吸烟状况、身体质量指数、体育活动和糖尿病持续时间进行分析时,研究人员也观察到了类似的结果。

由此可见,健康的低碳水化合物饮食评分与T2D成人死亡率降低显著相关。坚持均衡适度的低碳水化合物饮食,强调了健康的碳水化合物、植物性蛋白质和多不饱和脂肪,可防止T2D患者过早死亡。

原始出处:

Zhenzhen Wan,et al.Associations of Moderate Low-Carbohydrate Diets with Mortality among Patients with Type 2 Diabetes: A Prospective Cohort Study.JCEM.2022.https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac235/6569394

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    2022-08-20 achengzhao
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    2022-12-17 smallant2015
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    2022-04-21 塔和光同尘

    但是病人很多要不就是精细碳水,要不就是不吃碳水

    0

  5. 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    2022-04-19 yuanming9
  8. 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  9. 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PWV‐UP与PWV高度相关,可作为动脉硬化的生物标志物。PWV‐UP(而非PWV)与全因死亡率和心血管死亡率相关,这意味着PWV‐UP相关肽可能在多个方面参与了动脉硬化以外的多种病理过程。

JAHA:西班牙裔与非西班牙裔成人的心血管疾病死亡率比较

研究人员发现西班牙裔和NHW成人CVD死亡率存在异质性。与西班牙裔成年人相比,NHW成年人的CVD死亡率更高且下降速度更慢。

J INTERN MED:非酒精性脂肪肝患者骨折风险和随后死亡率

NAFLD患者的骨折发生率稍高,但骨折的长期风险与一般人群相当。这表明对NAFLD患者骨折危险因素的广泛监测是没有必要的。

CGH:结肠镜检查结果影响了非结直肠癌死亡率

本项研究证实在 CRC 筛查人群中,那些在 10 年内死于非 CRC 原因的人更有可能在基线结肠镜检查中发现生活习惯的高风险危害。

JAMA Dermatol:全球2020年皮肤黑色素瘤的发病率和死亡率

黑色素瘤仍是全球癌症控制和公共卫生的一个重要挑战