JGH:胆囊切除术可降低复杂性胆结石患者患胆管癌的风险

2022-04-19 xuyihan MedSci原创

胆结石在胆固醇胆石症患者的近亲中更经常发生,临床表现 1.胆囊结石 其症状取决于结石的大小和部位,以及有无阻塞和炎症等。部分胆囊结石患者终身无症状,即所谓隐性结石。

胆结石在全世界的发病率为5%-15%,它也是患者需要入院治疗的主要原因之一。大约每五个人患有胆结石的患者中就有一个人会出现腹痛或其他并发症,如急性胆囊炎、急性胆管炎或胆汁性胰腺炎。胆囊切除术是最常见的选择性腹部手术,通常适用于有症状的胆结石。由于胆结石与胆管癌(CCA)之间存在正相关关系,胆结石或胆囊切除术对健康问题的重要性在最近几年有所增加。在以前的研究中,复杂的胆结石患者有较高的CCA或肝细胞癌(HCC)的发病风险。

但是,胆囊切除术是否增加或减少CCA或HCC的风险仍有争议。本项研究旨在探究胆囊切除术对胆结石和复杂性胆结石亚组患者胆管癌 (CCA) 或肝细胞癌 (HCC) 风险的影响。

研究人员使用韩国国民健康保险数据库确定了患有胆结石病的患者共958677人,以及年龄匹配和性别匹配的对照组9586770人。复杂性胆结石定义为与急性胆囊炎或急性胆管炎相关的胆结石。与对照组相比,研究人员在接受胆囊切除术的胆结石患者中评估了 CCA 和 HCC 发生率的调整后风险比(调整后的风险比,95% 置信区间)。同时还分析了复杂胆结石患者的额外影响。

研究结果显示与对照组相比,胆结石患者的CCA (1.80, 1.67–1.93) 和HCC (1.03, 1.00–1.07) 风险增加。与未进行胆囊切除术的患者相比,胆囊切除术对CCA (1.94, 1.76–2.14) 和HCC (0.93, 0.87–0.99) 风险的影响最小。然而,复杂胆结石患者的 CCA 风险显着增加(5.62, 4.89-6.46),胆囊切除术后风险降低 30%(3.91, 3.43-4.46)。与肝内 CCA 或法特壶腹癌相比,胆囊切除术对肝外 CCA 的风险降低更大。然而,与对照组相比,复杂性胆结石患者和接受胆囊切除术的患者发生 HCC 的风险没有差异。

因此,本项研究证实患有复杂胆结石的患者发生 CCA 的风险显着增加,而胆囊切除术则部分降低了发生 CCA 的风险。胆结石或胆囊切除术对 HCC 的风险变化很小。

 

原始出处:

Hyeong Sik Ahn. Et al. Cholecystectomy reduces the risk of cholangiocarcinoma in patients with complicated gallstones, but has negligible effect on hepatocellular carcinoma. Journal of Gastroenterology and Hepatology.2022.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (10)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1877576, encodeId=4b6618e757677, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Jul 23 20:56:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241627, encodeId=df24124162ec1, content=<a href='/topic/show?id=aca283526f9' target=_blank style='color:#2F92EE;'>#胆结石#</a>患者患<a href='/topic/show?id=e37c83513be' target=_blank style='color:#2F92EE;'>#胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83526, encryptionId=aca283526f9, topicName=胆结石), TopicDto(id=83513, encryptionId=e37c83513be, topicName=胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sun Aug 28 15:30:03 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679021, encodeId=aeda16e9021ed, content=<a href='/topic/show?id=df0a834328b' target=_blank style='color:#2F92EE;'>#胆囊切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83432, encryptionId=df0a834328b, topicName=胆囊切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d227724361, createdName=huangshifeng, createdTime=Sat Sep 17 05:56:43 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212864, encodeId=7400121286473, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a255466055, createdName=ms2000001188720592, createdTime=Wed Apr 20 15:01:44 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212668, encodeId=ab8812126689b, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b6e2403217, createdName=1235bd28m70暂无昵称, createdTime=Tue Apr 19 21:21:50 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212667, encodeId=44ad121266e6e, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue Apr 19 21:16:07 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212778, encodeId=98311212e7880, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffe15705834, createdName=ms4000001809038213, createdTime=Wed Apr 20 10:02:00 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429809, encodeId=143b1429809f1, content=<a href='/topic/show?id=140783434c7' target=_blank style='color:#2F92EE;'>#胆囊切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83434, encryptionId=140783434c7, topicName=胆囊切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3f94230600, createdName=yangfl07, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587260, encodeId=cf7e158e260d4, content=<a href='/topic/show?id=9b4a42e01ed' target=_blank style='color:#2F92EE;'>#复杂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42701, encryptionId=9b4a42e01ed, topicName=复杂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b19f17453483, createdName=minlingfeng, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628514, encodeId=4c48162851419, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1877576, encodeId=4b6618e757677, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Jul 23 20:56:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241627, encodeId=df24124162ec1, content=<a href='/topic/show?id=aca283526f9' target=_blank style='color:#2F92EE;'>#胆结石#</a>患者患<a href='/topic/show?id=e37c83513be' target=_blank style='color:#2F92EE;'>#胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83526, encryptionId=aca283526f9, topicName=胆结石), TopicDto(id=83513, encryptionId=e37c83513be, topicName=胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sun Aug 28 15:30:03 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679021, encodeId=aeda16e9021ed, content=<a href='/topic/show?id=df0a834328b' target=_blank style='color:#2F92EE;'>#胆囊切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83432, encryptionId=df0a834328b, topicName=胆囊切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d227724361, createdName=huangshifeng, createdTime=Sat Sep 17 05:56:43 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212864, encodeId=7400121286473, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a255466055, createdName=ms2000001188720592, createdTime=Wed Apr 20 15:01:44 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212668, encodeId=ab8812126689b, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b6e2403217, createdName=1235bd28m70暂无昵称, createdTime=Tue Apr 19 21:21:50 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212667, encodeId=44ad121266e6e, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue Apr 19 21:16:07 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212778, encodeId=98311212e7880, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffe15705834, createdName=ms4000001809038213, createdTime=Wed Apr 20 10:02:00 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429809, encodeId=143b1429809f1, content=<a href='/topic/show?id=140783434c7' target=_blank style='color:#2F92EE;'>#胆囊切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83434, encryptionId=140783434c7, topicName=胆囊切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3f94230600, createdName=yangfl07, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587260, encodeId=cf7e158e260d4, content=<a href='/topic/show?id=9b4a42e01ed' target=_blank style='color:#2F92EE;'>#复杂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42701, encryptionId=9b4a42e01ed, topicName=复杂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b19f17453483, createdName=minlingfeng, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628514, encodeId=4c48162851419, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1877576, encodeId=4b6618e757677, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Jul 23 20:56:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241627, encodeId=df24124162ec1, content=<a href='/topic/show?id=aca283526f9' target=_blank style='color:#2F92EE;'>#胆结石#</a>患者患<a href='/topic/show?id=e37c83513be' target=_blank style='color:#2F92EE;'>#胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83526, encryptionId=aca283526f9, topicName=胆结石), TopicDto(id=83513, encryptionId=e37c83513be, topicName=胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sun Aug 28 15:30:03 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679021, encodeId=aeda16e9021ed, content=<a href='/topic/show?id=df0a834328b' target=_blank style='color:#2F92EE;'>#胆囊切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83432, encryptionId=df0a834328b, topicName=胆囊切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d227724361, createdName=huangshifeng, createdTime=Sat Sep 17 05:56:43 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212864, encodeId=7400121286473, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a255466055, createdName=ms2000001188720592, createdTime=Wed Apr 20 15:01:44 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212668, encodeId=ab8812126689b, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b6e2403217, createdName=1235bd28m70暂无昵称, createdTime=Tue Apr 19 21:21:50 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212667, encodeId=44ad121266e6e, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue Apr 19 21:16:07 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212778, encodeId=98311212e7880, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffe15705834, createdName=ms4000001809038213, createdTime=Wed Apr 20 10:02:00 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429809, encodeId=143b1429809f1, content=<a href='/topic/show?id=140783434c7' target=_blank style='color:#2F92EE;'>#胆囊切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83434, encryptionId=140783434c7, topicName=胆囊切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3f94230600, createdName=yangfl07, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587260, encodeId=cf7e158e260d4, content=<a href='/topic/show?id=9b4a42e01ed' target=_blank style='color:#2F92EE;'>#复杂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42701, encryptionId=9b4a42e01ed, topicName=复杂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b19f17453483, createdName=minlingfeng, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628514, encodeId=4c48162851419, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1877576, encodeId=4b6618e757677, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Jul 23 20:56:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241627, encodeId=df24124162ec1, content=<a href='/topic/show?id=aca283526f9' target=_blank style='color:#2F92EE;'>#胆结石#</a>患者患<a href='/topic/show?id=e37c83513be' target=_blank style='color:#2F92EE;'>#胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83526, encryptionId=aca283526f9, topicName=胆结石), TopicDto(id=83513, encryptionId=e37c83513be, topicName=胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sun Aug 28 15:30:03 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679021, encodeId=aeda16e9021ed, content=<a href='/topic/show?id=df0a834328b' target=_blank style='color:#2F92EE;'>#胆囊切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83432, encryptionId=df0a834328b, topicName=胆囊切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d227724361, createdName=huangshifeng, createdTime=Sat Sep 17 05:56:43 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212864, encodeId=7400121286473, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a255466055, createdName=ms2000001188720592, createdTime=Wed Apr 20 15:01:44 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212668, encodeId=ab8812126689b, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b6e2403217, createdName=1235bd28m70暂无昵称, createdTime=Tue Apr 19 21:21:50 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212667, encodeId=44ad121266e6e, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue Apr 19 21:16:07 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212778, encodeId=98311212e7880, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffe15705834, createdName=ms4000001809038213, createdTime=Wed Apr 20 10:02:00 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429809, encodeId=143b1429809f1, content=<a href='/topic/show?id=140783434c7' target=_blank style='color:#2F92EE;'>#胆囊切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83434, encryptionId=140783434c7, topicName=胆囊切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3f94230600, createdName=yangfl07, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587260, encodeId=cf7e158e260d4, content=<a href='/topic/show?id=9b4a42e01ed' target=_blank style='color:#2F92EE;'>#复杂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42701, encryptionId=9b4a42e01ed, topicName=复杂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b19f17453483, createdName=minlingfeng, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628514, encodeId=4c48162851419, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=)]
    2022-04-20 ms2000001188720592

    认真***

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1877576, encodeId=4b6618e757677, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Jul 23 20:56:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241627, encodeId=df24124162ec1, content=<a href='/topic/show?id=aca283526f9' target=_blank style='color:#2F92EE;'>#胆结石#</a>患者患<a href='/topic/show?id=e37c83513be' target=_blank style='color:#2F92EE;'>#胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83526, encryptionId=aca283526f9, topicName=胆结石), TopicDto(id=83513, encryptionId=e37c83513be, topicName=胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sun Aug 28 15:30:03 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679021, encodeId=aeda16e9021ed, content=<a href='/topic/show?id=df0a834328b' target=_blank style='color:#2F92EE;'>#胆囊切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83432, encryptionId=df0a834328b, topicName=胆囊切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d227724361, createdName=huangshifeng, createdTime=Sat Sep 17 05:56:43 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212864, encodeId=7400121286473, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a255466055, createdName=ms2000001188720592, createdTime=Wed Apr 20 15:01:44 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212668, encodeId=ab8812126689b, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b6e2403217, createdName=1235bd28m70暂无昵称, createdTime=Tue Apr 19 21:21:50 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212667, encodeId=44ad121266e6e, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue Apr 19 21:16:07 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212778, encodeId=98311212e7880, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffe15705834, createdName=ms4000001809038213, createdTime=Wed Apr 20 10:02:00 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429809, encodeId=143b1429809f1, content=<a href='/topic/show?id=140783434c7' target=_blank style='color:#2F92EE;'>#胆囊切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83434, encryptionId=140783434c7, topicName=胆囊切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3f94230600, createdName=yangfl07, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587260, encodeId=cf7e158e260d4, content=<a href='/topic/show?id=9b4a42e01ed' target=_blank style='color:#2F92EE;'>#复杂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42701, encryptionId=9b4a42e01ed, topicName=复杂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b19f17453483, createdName=minlingfeng, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628514, encodeId=4c48162851419, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=)]
    2022-04-19 1235bd28m70暂无昵称

    认真***

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1877576, encodeId=4b6618e757677, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Jul 23 20:56:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241627, encodeId=df24124162ec1, content=<a href='/topic/show?id=aca283526f9' target=_blank style='color:#2F92EE;'>#胆结石#</a>患者患<a href='/topic/show?id=e37c83513be' target=_blank style='color:#2F92EE;'>#胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83526, encryptionId=aca283526f9, topicName=胆结石), TopicDto(id=83513, encryptionId=e37c83513be, topicName=胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sun Aug 28 15:30:03 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679021, encodeId=aeda16e9021ed, content=<a href='/topic/show?id=df0a834328b' target=_blank style='color:#2F92EE;'>#胆囊切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83432, encryptionId=df0a834328b, topicName=胆囊切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d227724361, createdName=huangshifeng, createdTime=Sat Sep 17 05:56:43 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212864, encodeId=7400121286473, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a255466055, createdName=ms2000001188720592, createdTime=Wed Apr 20 15:01:44 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212668, encodeId=ab8812126689b, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b6e2403217, createdName=1235bd28m70暂无昵称, createdTime=Tue Apr 19 21:21:50 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212667, encodeId=44ad121266e6e, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue Apr 19 21:16:07 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212778, encodeId=98311212e7880, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffe15705834, createdName=ms4000001809038213, createdTime=Wed Apr 20 10:02:00 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429809, encodeId=143b1429809f1, content=<a href='/topic/show?id=140783434c7' target=_blank style='color:#2F92EE;'>#胆囊切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83434, encryptionId=140783434c7, topicName=胆囊切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3f94230600, createdName=yangfl07, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587260, encodeId=cf7e158e260d4, content=<a href='/topic/show?id=9b4a42e01ed' target=_blank style='color:#2F92EE;'>#复杂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42701, encryptionId=9b4a42e01ed, topicName=复杂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b19f17453483, createdName=minlingfeng, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628514, encodeId=4c48162851419, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=)]
    2022-04-19 医鸣惊人

    认真学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1877576, encodeId=4b6618e757677, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Jul 23 20:56:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241627, encodeId=df24124162ec1, content=<a href='/topic/show?id=aca283526f9' target=_blank style='color:#2F92EE;'>#胆结石#</a>患者患<a href='/topic/show?id=e37c83513be' target=_blank style='color:#2F92EE;'>#胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83526, encryptionId=aca283526f9, topicName=胆结石), TopicDto(id=83513, encryptionId=e37c83513be, topicName=胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sun Aug 28 15:30:03 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679021, encodeId=aeda16e9021ed, content=<a href='/topic/show?id=df0a834328b' target=_blank style='color:#2F92EE;'>#胆囊切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83432, encryptionId=df0a834328b, topicName=胆囊切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d227724361, createdName=huangshifeng, createdTime=Sat Sep 17 05:56:43 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212864, encodeId=7400121286473, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a255466055, createdName=ms2000001188720592, createdTime=Wed Apr 20 15:01:44 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212668, encodeId=ab8812126689b, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b6e2403217, createdName=1235bd28m70暂无昵称, createdTime=Tue Apr 19 21:21:50 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212667, encodeId=44ad121266e6e, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue Apr 19 21:16:07 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212778, encodeId=98311212e7880, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffe15705834, createdName=ms4000001809038213, createdTime=Wed Apr 20 10:02:00 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429809, encodeId=143b1429809f1, content=<a href='/topic/show?id=140783434c7' target=_blank style='color:#2F92EE;'>#胆囊切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83434, encryptionId=140783434c7, topicName=胆囊切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3f94230600, createdName=yangfl07, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587260, encodeId=cf7e158e260d4, content=<a href='/topic/show?id=9b4a42e01ed' target=_blank style='color:#2F92EE;'>#复杂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42701, encryptionId=9b4a42e01ed, topicName=复杂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b19f17453483, createdName=minlingfeng, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628514, encodeId=4c48162851419, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=)]
    2022-04-20 ms4000001809038213

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1877576, encodeId=4b6618e757677, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Jul 23 20:56:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241627, encodeId=df24124162ec1, content=<a href='/topic/show?id=aca283526f9' target=_blank style='color:#2F92EE;'>#胆结石#</a>患者患<a href='/topic/show?id=e37c83513be' target=_blank style='color:#2F92EE;'>#胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83526, encryptionId=aca283526f9, topicName=胆结石), TopicDto(id=83513, encryptionId=e37c83513be, topicName=胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sun Aug 28 15:30:03 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679021, encodeId=aeda16e9021ed, content=<a href='/topic/show?id=df0a834328b' target=_blank style='color:#2F92EE;'>#胆囊切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83432, encryptionId=df0a834328b, topicName=胆囊切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d227724361, createdName=huangshifeng, createdTime=Sat Sep 17 05:56:43 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212864, encodeId=7400121286473, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a255466055, createdName=ms2000001188720592, createdTime=Wed Apr 20 15:01:44 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212668, encodeId=ab8812126689b, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b6e2403217, createdName=1235bd28m70暂无昵称, createdTime=Tue Apr 19 21:21:50 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212667, encodeId=44ad121266e6e, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue Apr 19 21:16:07 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212778, encodeId=98311212e7880, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffe15705834, createdName=ms4000001809038213, createdTime=Wed Apr 20 10:02:00 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429809, encodeId=143b1429809f1, content=<a href='/topic/show?id=140783434c7' target=_blank style='color:#2F92EE;'>#胆囊切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83434, encryptionId=140783434c7, topicName=胆囊切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3f94230600, createdName=yangfl07, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587260, encodeId=cf7e158e260d4, content=<a href='/topic/show?id=9b4a42e01ed' target=_blank style='color:#2F92EE;'>#复杂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42701, encryptionId=9b4a42e01ed, topicName=复杂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b19f17453483, createdName=minlingfeng, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628514, encodeId=4c48162851419, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1877576, encodeId=4b6618e757677, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Jul 23 20:56:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241627, encodeId=df24124162ec1, content=<a href='/topic/show?id=aca283526f9' target=_blank style='color:#2F92EE;'>#胆结石#</a>患者患<a href='/topic/show?id=e37c83513be' target=_blank style='color:#2F92EE;'>#胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83526, encryptionId=aca283526f9, topicName=胆结石), TopicDto(id=83513, encryptionId=e37c83513be, topicName=胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sun Aug 28 15:30:03 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679021, encodeId=aeda16e9021ed, content=<a href='/topic/show?id=df0a834328b' target=_blank style='color:#2F92EE;'>#胆囊切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83432, encryptionId=df0a834328b, topicName=胆囊切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d227724361, createdName=huangshifeng, createdTime=Sat Sep 17 05:56:43 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212864, encodeId=7400121286473, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a255466055, createdName=ms2000001188720592, createdTime=Wed Apr 20 15:01:44 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212668, encodeId=ab8812126689b, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b6e2403217, createdName=1235bd28m70暂无昵称, createdTime=Tue Apr 19 21:21:50 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212667, encodeId=44ad121266e6e, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue Apr 19 21:16:07 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212778, encodeId=98311212e7880, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffe15705834, createdName=ms4000001809038213, createdTime=Wed Apr 20 10:02:00 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429809, encodeId=143b1429809f1, content=<a href='/topic/show?id=140783434c7' target=_blank style='color:#2F92EE;'>#胆囊切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83434, encryptionId=140783434c7, topicName=胆囊切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3f94230600, createdName=yangfl07, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587260, encodeId=cf7e158e260d4, content=<a href='/topic/show?id=9b4a42e01ed' target=_blank style='color:#2F92EE;'>#复杂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42701, encryptionId=9b4a42e01ed, topicName=复杂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b19f17453483, createdName=minlingfeng, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628514, encodeId=4c48162851419, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=)]
  10. [GetPortalCommentsPageByObjectIdResponse(id=1877576, encodeId=4b6618e757677, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Jul 23 20:56:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241627, encodeId=df24124162ec1, content=<a href='/topic/show?id=aca283526f9' target=_blank style='color:#2F92EE;'>#胆结石#</a>患者患<a href='/topic/show?id=e37c83513be' target=_blank style='color:#2F92EE;'>#胆管癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83526, encryptionId=aca283526f9, topicName=胆结石), TopicDto(id=83513, encryptionId=e37c83513be, topicName=胆管癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Sun Aug 28 15:30:03 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1679021, encodeId=aeda16e9021ed, content=<a href='/topic/show?id=df0a834328b' target=_blank style='color:#2F92EE;'>#胆囊切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83432, encryptionId=df0a834328b, topicName=胆囊切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4d227724361, createdName=huangshifeng, createdTime=Sat Sep 17 05:56:43 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212864, encodeId=7400121286473, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a255466055, createdName=ms2000001188720592, createdTime=Wed Apr 20 15:01:44 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212668, encodeId=ab8812126689b, content=认真***, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b6e2403217, createdName=1235bd28m70暂无昵称, createdTime=Tue Apr 19 21:21:50 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212667, encodeId=44ad121266e6e, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue Apr 19 21:16:07 CST 2022, time=2022-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1212778, encodeId=98311212e7880, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffe15705834, createdName=ms4000001809038213, createdTime=Wed Apr 20 10:02:00 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429809, encodeId=143b1429809f1, content=<a href='/topic/show?id=140783434c7' target=_blank style='color:#2F92EE;'>#胆囊切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83434, encryptionId=140783434c7, topicName=胆囊切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3f94230600, createdName=yangfl07, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587260, encodeId=cf7e158e260d4, content=<a href='/topic/show?id=9b4a42e01ed' target=_blank style='color:#2F92EE;'>#复杂性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42701, encryptionId=9b4a42e01ed, topicName=复杂性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b19f17453483, createdName=minlingfeng, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628514, encodeId=4c48162851419, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Wed Apr 20 03:56:43 CST 2022, time=2022-04-20, status=1, ipAttribution=)]

相关资讯

Clin Cancer Res:雷莫芦单抗治疗晚期胆道癌的疗效和安全性

雷莫芦单抗在晚期胆管癌患者中的耐受性良好,疗效不劣于已有化疗方案。

JGH: 胆囊切除术可降低复杂胆结石患者发生胆管癌的风险

胆结石是世界范围的常见病。在我国自然人群中,胆结石的发病率达10%左右。女性患者多见,尤其是较肥胖的女性,男女之比约为1∶2。胆结石是胆管(胆囊)癌的致病因素。

Lancet Gastroenterol Hepatol:Infigratinib在FGFR2融合或重排的晚期胆管癌中的疗效和安全性

Infigratinib在既往治疗过的具有FGFR2基因融合或重排的局部晚期或转移性胆管癌患者中具有良好的临床活性和可控制的不良事件

Pemigatinib治疗FGFR2融合或重排的晚期胆管癌,CHMP持积极评价

人用药品委员会(CHMP)对pemigatinib治疗无法切除的局部晚期或转移性胆管癌持积极意见,建议批准上市。

Int J Cancer:意外发现:AGEs摄入量与肝癌风险呈负相关!

与预期相反,在一项大型跨国队列研究中,较高的晚期糖基化终末产物(AGEs)膳食摄入量,包括来自油炸、烤制或烤制食品中的AGEs,与肝细胞癌(HCC)风险下降相关。