Alz Dis Assoc Dis:慢性压力可增加民众患阿尔茨海默症的风险

2015-12-13 QQduhq 译 MedSci原创

美国阿尔茨海默症患者约47万人。大多数患者的首发患病表现为轻度认知功能障碍。这是痴呆表现的前兆且极大增加民众患阿尔茨海默症的风险,并且可在未来几个月或几年后迅速恶化。在当今研究中,爱因斯坦医学院和蒙蒂菲奥里医疗系统的研究人员着手探究慢性压力与遗忘型轻度认知障碍(aMCI,最常见的认知障碍,主要表现为记忆力减退)之间的联系。 研究人员对EAS中507名参与人员进行探究,并深入分析相应数据。 自199

美国阿尔茨海默症患者约有47万人。大多数患者的首发患病表现为轻度认知功能障碍。这是痴呆表现的前兆且极大增加民众患阿尔茨海默症的风险,并且可在未来几个月或几年后迅速恶化。


在当今研究中,爱因斯坦医学院和蒙蒂菲奥里医疗系统的研究人员着手探究慢性压力与遗忘型轻度认知障碍(aMCI,最常见的认知障碍,主要表现为记忆力减退)之间的联系。 

研究人员对EAS中507名参与人员进行探究,并深入分析相应数据。 

自1993年以来,EAS已系统性招募了507名70岁及以上、生活中布朗克斯县的老人进行探究。

参与人员每年进行一次全面评估,包括临床评估、神经心理测试、心理活动及相应措施、病史、日常生活活动评估和记忆力问题及家属或护理人员反映的认知功能障碍问题。 

2005年,EAS开始评估压力量表(PSS)以评估老人的压力。PSS被广泛用于评估民众的慢性压力,主要通过14项与民众心理压力有关的内容进行测试。通过评估可感知民众一个月前由于生活环境、生活现状、未来可能事件和其他原因等出现的压力。PSS评分范围为0-56分,得分越高表明压力越大。 

遗忘型轻度认知障碍(aMCI)是基于临床的诊断标准,同时也结合随访测试结果和参与者及其护理者的健忘自诉。

所有参与者在首次PSS评估中均未患有aMCI或痴呆。然后研究人员对他们每年进行1次随访评估,平均为3.6年。 

研究过程中,71名参与者被诊断为aMCI。压力水平越高,他们患aMCI的风险就越大。PSS分数每增加5分,参与者患aMCI的风险便增加30%。 

依据PSS评分结果,参与者被分成五组(压力最大逐渐至压力最小)。压力最大组中参与者aMCI的风险是其他4组的2.5倍。该组女性较多,受教育水平较低且抑郁情绪较明显。

为了证实慢性压力导致民众患aMCI的风险增加,研究人员试图探究抑郁情绪是否也对民众患有aMCI有促进作用。但是,他们未发现抑郁在压力和aMCI发病之间关系的作用。 

Mindy Katz认为,压力对我们的日常生活带来一定的影响,我们需要采取一些措施来应对,例如正念减压疗法、认知行为治疗和消除紧张情绪的药物等。这些有助于减缓民众认知功能减退过程。同时老年人减轻压力有助于延迟或预防阿尔茨海默症的发生。

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1975987, encodeId=9f1319e5987ed, content=<a href='/topic/show?id=0f9353496b0' target=_blank style='color:#2F92EE;'>#慢性压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53496, encryptionId=0f9353496b0, topicName=慢性压力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Tue Dec 15 11:27:00 CST 2015, time=2015-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816673, encodeId=d4b318166e388, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Thu May 05 02:27:00 CST 2016, time=2016-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012047, encodeId=3726201204ece, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Feb 28 17:27:00 CST 2016, time=2016-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1817696, encodeId=ce9a181e69663, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Feb 09 21:27:00 CST 2016, time=2016-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48460, encodeId=a06a4846034, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:17:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47444, encodeId=fc8e4e44406, content=痴呆一直是难题 希望有好的治法, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160319/IMG56EC9696F32B05996.jpg, createdBy=0eac1630810, createdName=moonlight1, createdTime=Thu Dec 24 10:32:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470050, encodeId=673d14e005039, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Tue Dec 15 07:27:00 CST 2015, time=2015-12-15, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    好文章,值得看。

    0

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    2015-12-24 moonlight1

    痴呆一直是难题 希望有好的治法

    0

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CDC:喂养宠物狗有益于儿童的心理和行为健康

CDC:喂养宠物狗有益于儿童的心理和行为健康据发表于Centers for Disease Control and Prevention的一项新的研究表明,家庭喂养一只宠物狗或可保护儿童免于焦虑的发生。在美国,儿童精神疾病和肥胖是一项重要的公共健康问题。因为这些疾病始于儿童童年时期,因此需要早期的预防和干预。目前已知,宠物狗与成人的健康有关。在澳大利亚以及英国,喂养宠物狗可增加5-12岁儿童的体