JAHA:经皮冠状动脉血运重建术治疗急性冠脉综合征的女性和男性预后有差异吗?

2017-01-22 xing.T MedSci原创

在接受早期侵入性治疗策略和冠状动脉血运重建的急性冠脉综合征女性患者比男性患者发生不良临床预后的风险要高。

非ST段抬高的急性冠脉综合征的住院女性患者相比于男性患者具有更加糟糕的临床预后。早期的以提示冠状动脉血运重建的侵入性治疗策略可以减少临床预后的性别差异。然而,目前的研究很少有评估接受早期侵入性治疗策略的急性冠脉综合征的患者在临床预后上男性和女性之间是否存在差异。近日,心血管疾病领域权威杂志JAHA上专门针对这一问题发表了一篇研究文章。

研究人员以在加拿大安大略从2008年至2011年期间住院接受快速心导管检查的急性冠脉综合征患者人群为基础组成的队列,并进行了长达2年的随访研究。研究人员比较男性和女性患者的临床预后,并根据使用冠状动脉血运重建术的情况进行分层。使用倾向性得分的逆概率加权来说明男性和女性患者之间基线特征的测量差异。

在住院期间接受心导管术的23473例急性冠脉综合征患者中,66.1%的男性患者和51.8%的女性在同一住院期间进行了冠状动脉血运重建。在接受冠状动脉血运重建的患者倾向-加权队列中,1年死亡率或急性冠脉综合征复发率在男性为10.6%(参考),而在女性中为13.1%(风险比为1.24;95%可信区间为1.16-1.33)。相反,对于那些没有接受冠状动脉血运重建的患者的1年预后在男性患者和女性患者之间并没有显著的差异(17.8% vs. 16.9%;风险比为1.06;95%可信区间为0.99-1.14)或更长的随访时间预后在男性患者和女性患者之间也没有差异。

由此可见,在接受早期侵入性治疗策略和冠状动脉血运重建的急性冠脉综合征女性患者比男性患者发生不良临床预后的风险要高。

原始出处:

Jacob A. Udell,et al. Outcomes of Women and Men With Acute Coronary Syndrome Treated With and Without Percutaneous Coronary Revascularization. JAHA.2017.


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    2017-01-27 doctorJiangchao

    继续学习

    0

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    2017-01-24 zhaohui6731
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    2017-01-22 tanxingdoctor

    学习了,很不错

    0