2010年中国慢性淋巴细胞白血病诊断与治疗专家共识

2013-11-22 MedSci MedSci原创

近十几年来,国际上在慢性淋巴细胞白血病(CLL)基础研究、新的预后标志、诊断标准及治疗选择方面都取得了巨大进展,我国对CLL的研究也取得较大进展,但与国外研究差距较大,需要进一步规范临床诊断与治疗,促使我们制订中国CLL诊断与治疗专家共识,以促进我国各级血液科医生提高CLL及相关慢性B淋巴细胞增殖性疾病(B—LPD)的诊断和鉴别诊断水平,规范CLL的治疗。CLL是一种B淋巴细胞克隆性增殖的肿瘤性疾

近十几年来,国际上在慢性淋巴细胞白血病(CLL)基础研究、新的预后标志、诊断标准及治疗选择方面都取得了巨大进展,我国对CLL的研究也取得较大进展,但与国外研究差距较大,需要进一步规范临床诊断与治疗,促使我们制订中国CLL诊断与治疗专家共识,以促进我国各级血液科医生提高CLL及相关慢性B淋巴细胞增殖性疾病(B—LPD)的诊断和鉴别诊断水平,规范CLL的治疗。


CLL是一种B淋巴细胞克隆性增殖的肿瘤性疾病,其特点为成熟形态的淋巴细胞在体内积聚,使血液和骨髓中淋巴细胞增多,进而引起淋巴结、肝、脾肿大,并可累及其他组织器官。CLL特指B细胞肿瘤,既往T—CLL现称为T幼稚淋巴细胞白血病(T-PLL)小细胞变异型。CLL的精确诊断主要依据血细胞计数、血涂片细胞形态学和免疫分型,不典型的患者需要结合其他检查进一步明确。

原文出处:

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=17573, encodeId=40b41e5739b, content=超赞,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Wed Mar 04 14:30:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997796, encodeId=6057199e7968a, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Mon Jun 02 13:34:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719006, encodeId=42341e1900604, content=<a href='/topic/show?id=e32e915e89c' target=_blank style='color:#2F92EE;'>#诊断与治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91578, encryptionId=e32e915e89c, topicName=诊断与治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85a832689492, createdName=木头人524, createdTime=Fri May 23 00:34:00 CST 2014, time=2014-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1844422, encodeId=8c081844422d8, content=<a href='/topic/show?id=5d2f206482e' target=_blank style='color:#2F92EE;'>#专家共识#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20648, encryptionId=5d2f206482e, topicName=专家共识)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 15 23:34:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301991, encodeId=5aac13019913c, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Sun Nov 24 04:34:00 CST 2013, time=2013-11-24, status=1, ipAttribution=)]
    2015-03-04 xiaoai5777

    超赞,好文章

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=17573, encodeId=40b41e5739b, content=超赞,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Wed Mar 04 14:30:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997796, encodeId=6057199e7968a, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Mon Jun 02 13:34:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719006, encodeId=42341e1900604, content=<a href='/topic/show?id=e32e915e89c' target=_blank style='color:#2F92EE;'>#诊断与治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91578, encryptionId=e32e915e89c, topicName=诊断与治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85a832689492, createdName=木头人524, createdTime=Fri May 23 00:34:00 CST 2014, time=2014-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1844422, encodeId=8c081844422d8, content=<a href='/topic/show?id=5d2f206482e' target=_blank style='color:#2F92EE;'>#专家共识#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20648, encryptionId=5d2f206482e, topicName=专家共识)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 15 23:34:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301991, encodeId=5aac13019913c, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Sun Nov 24 04:34:00 CST 2013, time=2013-11-24, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=17573, encodeId=40b41e5739b, content=超赞,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Wed Mar 04 14:30:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997796, encodeId=6057199e7968a, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Mon Jun 02 13:34:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719006, encodeId=42341e1900604, content=<a href='/topic/show?id=e32e915e89c' target=_blank style='color:#2F92EE;'>#诊断与治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91578, encryptionId=e32e915e89c, topicName=诊断与治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85a832689492, createdName=木头人524, createdTime=Fri May 23 00:34:00 CST 2014, time=2014-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1844422, encodeId=8c081844422d8, content=<a href='/topic/show?id=5d2f206482e' target=_blank style='color:#2F92EE;'>#专家共识#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20648, encryptionId=5d2f206482e, topicName=专家共识)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 15 23:34:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301991, encodeId=5aac13019913c, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Sun Nov 24 04:34:00 CST 2013, time=2013-11-24, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=17573, encodeId=40b41e5739b, content=超赞,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Wed Mar 04 14:30:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997796, encodeId=6057199e7968a, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Mon Jun 02 13:34:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719006, encodeId=42341e1900604, content=<a href='/topic/show?id=e32e915e89c' target=_blank style='color:#2F92EE;'>#诊断与治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91578, encryptionId=e32e915e89c, topicName=诊断与治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85a832689492, createdName=木头人524, createdTime=Fri May 23 00:34:00 CST 2014, time=2014-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1844422, encodeId=8c081844422d8, content=<a href='/topic/show?id=5d2f206482e' target=_blank style='color:#2F92EE;'>#专家共识#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20648, encryptionId=5d2f206482e, topicName=专家共识)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 15 23:34:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301991, encodeId=5aac13019913c, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Sun Nov 24 04:34:00 CST 2013, time=2013-11-24, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=17573, encodeId=40b41e5739b, content=超赞,好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Wed Mar 04 14:30:00 CST 2015, time=2015-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997796, encodeId=6057199e7968a, content=<a href='/topic/show?id=75ff66001cd' target=_blank style='color:#2F92EE;'>#淋巴细胞白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66001, encryptionId=75ff66001cd, topicName=淋巴细胞白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Mon Jun 02 13:34:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1719006, encodeId=42341e1900604, content=<a href='/topic/show?id=e32e915e89c' target=_blank style='color:#2F92EE;'>#诊断与治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91578, encryptionId=e32e915e89c, topicName=诊断与治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=85a832689492, createdName=木头人524, createdTime=Fri May 23 00:34:00 CST 2014, time=2014-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1844422, encodeId=8c081844422d8, content=<a href='/topic/show?id=5d2f206482e' target=_blank style='color:#2F92EE;'>#专家共识#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20648, encryptionId=5d2f206482e, topicName=专家共识)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Wed Jan 15 23:34:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301991, encodeId=5aac13019913c, content=<a href='/topic/show?id=82a6659902c' target=_blank style='color:#2F92EE;'>#淋巴细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65990, encryptionId=82a6659902c, topicName=淋巴细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Sun Nov 24 04:34:00 CST 2013, time=2013-11-24, status=1, ipAttribution=)]

相关资讯

Nature:抗原非依赖型的细胞信号引发慢性淋巴细胞白血病的分子机制

近日,来自弗莱堡大学生物信号研究中心Hassan Jumaa教授领导的实验团队发现了一种促使免疫细胞转变为恶性癌细胞的分子机制。慢性淋巴细胞性白血病(Chronic Lymphocytic Leukaemia,CLL)是西方国家常见的一种血癌,患者机体细胞携带着致病转化的关键因子,国际著名杂志Nature刊登了研究者的研究成果,理解这些潜在的机制对于开发出减少疾病效应的新型疗法非常重要。 健康人

ASCO 2012:CLL诊治 从过去走向未来

       2012年,ASCO最高荣誉奖——戴维 卡尔诺夫斯基(David A. Karnofsky)纪念奖授予了北岸长岛犹太医学中心的雷(Rai)教授。在获奖演说中,Rai教授不仅与大家分享了他们过去40多年间在慢性淋巴细胞白血病(CLL)方面的研究成就,还对CLL诊治从Karnofsky时代到目前所取得的重大进展进行了详细介绍。 分期及预

ibrutinib与rituximab联合用药治疗慢性淋巴细胞白血病

       美国得克萨斯大学安德森癌症中心进行的一项二期临床试验利用双轨方式将药物ibrutinib与利妥昔单抗(rituximab)联合起来用于治疗白血病 style=color:blue >慢性淋巴细胞白血病(CLL),疗效显著且副作用小。研究人员近期在美国血液学会第54届年会上发表了上述研究成果。   安德森癌症中心白血病科助理教授、该研究首席研究人员Jan