麻醉疼痛科

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Reg Anesth Pain Med：在麻醉医生眼中，雷莫司琼可不止是止吐那么简单哦！

2015-08-22 MedSci MedSci原创

5-HT3受体拮抗剂腰麻并发症
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腰麻（SA）常用于腹部及下肢手术，由于交感神经被阻滞，常出现低血压及心动过缓等副作用。首尔国立大学的研究人员将2类5-HT3受体拮抗剂对SA诱导的副作用的影响进行了比较，旨在对雷莫司琼是否比昂丹司琼能更有效的减少SA诱导的血压（BP）和心率（HR）的降低进行评价。   本次研究共招募了117例在腰麻下行矫形外科手术的患者。通过静脉注射分别给予患者0.3mg雷莫司琼（n=39,R组）、

腰麻（SA）常用于腹部及下肢手术，由于交感神经被阻滞，常出现低血压及心动过缓等副作用。首尔国立大学的研究人员将2类5-HT3受体拮抗剂对SA诱导的副作用的影响进行了比较，旨在对雷莫司琼是否比昂丹司琼能更有效的减少SA诱导的血压（BP）和心率（HR）的降低进行评价。

本次研究共招募了117例在腰麻下行矫形外科手术的患者。通过静脉注射分别给予患者0.3mg雷莫司琼（n=39,R组）、4mg昂丹司琼(n=39,O4组)或者8mg昂丹司琼(n=39,O8组)。术前（基线）及术中对收缩压(SBP)、 舒张压 BP (DBP)、平均动脉压(MBP)、HR、以及最低SBP、DBP、MBP、HR值进行测量。并对患者术后恶心呕吐的发生率、补救止吐药的需要、病人自控镇痛的数量以及术后48h的疼痛分数进行了测定。

 

结果显示，在进行SA后，所有三组的SBP、DBP、MBP和HR都低于其基线值，并且3组间的基线值没有显著差异。与O4组及O8组相比，R组SBP(P < 0.001),DBP(P = 0.001)基线值与最低值间的差异显著减少；与O4组相比R组HR(P=0.032)基线值与最低值间的差异显著减少。组间术后恶心呕吐、补救止吐药的需要、病人自控镇痛的数量以及术后48h的疼痛分数的差异没有统计学意义。

 

本研究表明：与昂丹司琼（4或8mg）相比，雷莫司琼(0.3mg)可显著减少SA诱导的血压降低的出现；同时雷莫司琼亦可显著减少SA诱导的心率降低的出现。 

原始出处：

Hyun-Jung Shin,Eun-Su Choi,Gwan-WooLee,and Sang-Hwan Do. Effects of Preoperative Serotonin-Receptor-Antagonist Administration in Spinal Anesthesia–Induced Hypotension.Reg Anesth Pain Med. 2015 Sep-Oct;40(5):583-8.

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    2017-02-20 Liufeng6206

    这个真不错！

    0

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    2017-01-22 1e1f3a67m99(暂无匿称)

    好好学习

    0

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    2016-09-15 1e10c84am36(暂无匿称)

    文章不错，值得拜读

    0

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    2015-11-26 whlxd

    #雷莫司#

    0

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    2016-04-11 Wechat4343a314

    关注药物的多作用应用

    0

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    2015-09-15 周虎

    #麻醉医生#

    0

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    2016-03-30 忠诚向上

    好好学习一下

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=177101, encodeId=d7171e7101b8, content=这个真不错！, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon Feb 20 08:38:37 CST 2017, time=2017-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171938, encodeId=541b1e19380b, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKPeeEwPQq9TMKicgf58mJaQxKhBsHa2jnPrEYVBnZ8QD4tbiaUo3aNqM7EUfOzoPiaEELUb7VRE0HKA/132, createdBy=afcb2012691, createdName=1e1f3a67m99(暂无匿称), createdTime=Sun Jan 22 10:45:45 CST 2017, time=2017-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127162, encodeId=547a12e162f7, content=文章不错，值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 15 07:38:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819010, encodeId=1c1d1819010ae, content=<a href='/topic/show?id=9c35988489d' target=_blank style='color:#2F92EE;'>#雷莫司#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98848, encryptionId=9c35988489d, topicName=雷莫司)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Thu Nov 26 11:09:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77463, encodeId=a7dfe7463f5, content=关注药物的多作用应用, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160412/IMG570C62AB017373724.jpg, createdBy=f6b41705718, createdName=Wechat4343a314, createdTime=Mon Apr 11 21:57:00 CST 2016, time=2016-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683493, encodeId=2456168349385, content=<a href='/topic/show?id=e1c710305098' target=_blank style='color:#2F92EE;'>#麻醉医生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103050, encryptionId=e1c710305098, topicName=麻醉医生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c24827977639, createdName=周虎, createdTime=Tue Sep 15 07:09:00 CST 2015, time=2015-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74782, encodeId=b513e4782e3, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74783, encodeId=c28fe47836a, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74784, encodeId=04b9e4784aa, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74785, encodeId=d512e47853f, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=)]
    2016-03-30 忠诚向上

    好好学习一下

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=177101, encodeId=d7171e7101b8, content=这个真不错！, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon Feb 20 08:38:37 CST 2017, time=2017-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171938, encodeId=541b1e19380b, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKPeeEwPQq9TMKicgf58mJaQxKhBsHa2jnPrEYVBnZ8QD4tbiaUo3aNqM7EUfOzoPiaEELUb7VRE0HKA/132, createdBy=afcb2012691, createdName=1e1f3a67m99(暂无匿称), createdTime=Sun Jan 22 10:45:45 CST 2017, time=2017-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127162, encodeId=547a12e162f7, content=文章不错，值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 15 07:38:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819010, encodeId=1c1d1819010ae, content=<a href='/topic/show?id=9c35988489d' target=_blank style='color:#2F92EE;'>#雷莫司#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98848, encryptionId=9c35988489d, topicName=雷莫司)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Thu Nov 26 11:09:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77463, encodeId=a7dfe7463f5, content=关注药物的多作用应用, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160412/IMG570C62AB017373724.jpg, createdBy=f6b41705718, createdName=Wechat4343a314, createdTime=Mon Apr 11 21:57:00 CST 2016, time=2016-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683493, encodeId=2456168349385, content=<a href='/topic/show?id=e1c710305098' target=_blank style='color:#2F92EE;'>#麻醉医生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103050, encryptionId=e1c710305098, topicName=麻醉医生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c24827977639, createdName=周虎, createdTime=Tue Sep 15 07:09:00 CST 2015, time=2015-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74782, encodeId=b513e4782e3, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74783, encodeId=c28fe47836a, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74784, encodeId=04b9e4784aa, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74785, encodeId=d512e47853f, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=)]
    2016-03-30 忠诚向上

    好好学习一下

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=177101, encodeId=d7171e7101b8, content=这个真不错！, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baca1705213, createdName=Liufeng6206, createdTime=Mon Feb 20 08:38:37 CST 2017, time=2017-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=171938, encodeId=541b1e19380b, content=好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKPeeEwPQq9TMKicgf58mJaQxKhBsHa2jnPrEYVBnZ8QD4tbiaUo3aNqM7EUfOzoPiaEELUb7VRE0HKA/132, createdBy=afcb2012691, createdName=1e1f3a67m99(暂无匿称), createdTime=Sun Jan 22 10:45:45 CST 2017, time=2017-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=127162, encodeId=547a12e162f7, content=文章不错，值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 15 07:38:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819010, encodeId=1c1d1819010ae, content=<a href='/topic/show?id=9c35988489d' target=_blank style='color:#2F92EE;'>#雷莫司#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98848, encryptionId=9c35988489d, topicName=雷莫司)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Thu Nov 26 11:09:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77463, encodeId=a7dfe7463f5, content=关注药物的多作用应用, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160412/IMG570C62AB017373724.jpg, createdBy=f6b41705718, createdName=Wechat4343a314, createdTime=Mon Apr 11 21:57:00 CST 2016, time=2016-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683493, encodeId=2456168349385, content=<a href='/topic/show?id=e1c710305098' target=_blank style='color:#2F92EE;'>#麻醉医生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103050, encryptionId=e1c710305098, topicName=麻醉医生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c24827977639, createdName=周虎, createdTime=Tue Sep 15 07:09:00 CST 2015, time=2015-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74782, encodeId=b513e4782e3, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74783, encodeId=c28fe47836a, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74784, encodeId=04b9e4784aa, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74785, encodeId=d512e47853f, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Mar 30 15:53:00 CST 2016, time=2016-03-30, status=1, ipAttribution=)]
    2016-03-30 忠诚向上

    好好学习一下

    0

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