Neurology:左心房疾病是缺血性卒中的独立危险因素

2016-07-18 phylis 译 MedSci原创

背景:最近报道显示左心房疾病是缺血性卒中的独立危险因素,研究者试图探讨心房内传导阻滞(aIAB)是否是脑卒中的独立的危险因素。方法:研究者检查社区动脉粥样硬化风险研究(ARIC)中的14716患者,aIAB和缺血性卒中发生之间的关系(平均年龄54±5.8岁;55%女性;26%为黑人)。在ARIC研究期间(1987-1989),从基线数字心电图识别aLAB患者,并对其进行3次随访研究访问(1990-

背景:最近报道显示左心房疾病是缺血性卒中的独立危险因素,研究者试图探讨心房内传导阻滞(aIAB)是否是脑卒中的独立的危险因素。

方法:研究者检查社区动脉粥样硬化风险研究(ARIC)中的14716患者,aIAB和缺血性卒中发生之间的关系(平均年龄54±5.8岁;55%女性;26%为黑人)。在ARIC研究期间(1987-1989),从基线数字心电图识别aLAB患者,并对其进行3次随访研究访问(1990-1992年,1993-1995年,和1996-1998年)。对缺血性脑卒中事件的确定直至2010年12月31日。

结果:有266(1.8%)例参与者有aIAB的证据。随访时间的中位数为22年,共有916(6.2%)例缺血性卒中事件发生。有aIAB(发生率为8.05,95% CI  5.7,11.4)的患者缺血性卒中发病率(每1000人年)是无aIAB患者的两倍以上(发病率3.14,95% CI 2.94,3.35)。在多变量Cox回归分析中,校正脑卒中潜在的危险因素和潜在的混杂因素,aIAB与缺血性卒中的风险增加相关(HR 1.63,95% CI 1.13-2.34)。按照年龄、性别和种族分层后,结果是一致。

结论:在ARIC研究中、aIAB与缺血性卒中相关的事件发生相关,这就显示左心房疾病是脑卒中独立的危险因素。

原始出处:

O'Neal WT, Kamel H, et al. Advanced interatrial block and ischemic stroke: The Atherosclerosis Risk in Communities Study. Neurology. 2016 Jun 24.


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    2016-10-11 ylzr123

    赞了,认真探究、学习。

    0

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    2016-08-10 yinhl1978
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    2016-07-20 sodoo