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Br J Anaesth：丙泊酚可对杏仁核依赖的情绪记忆系统产生影响

2015-08-06 张森 译 MedSci原创

丙泊酚遗忘杏仁核
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亚临床剂量的丙泊酚可以导致顺行性遗忘（对造成失忆的事件后发生的事物发生遗忘的失忆症）。有研究表明杏仁核依赖的情绪记忆系统可调节整合海马对情绪唤醒及神经体液压力的反应，然而目前仍不清楚丙泊酚如何对杏仁核依赖的情绪记忆系统产生影响。本研究使用功能性核磁共振成像技术，探讨丙泊酚对人情绪记忆系统的影响。 在本次研究中，35位健康受试者被随机分为丙泊酚组（估算脑内浓度达到0.90μg/ml）和安慰剂对照组

亚临床剂量的丙泊酚可以导致顺行性遗忘（对造成失忆的事件后发生的事物发生遗忘的失忆症）。有研究表明杏仁核依赖的情绪记忆系统可调节整合海马对情绪唤醒及神经体液压力的反应，然而目前仍不清楚丙泊酚如何对杏仁核依赖的情绪记忆系统产生影响。本研究使用功能性核磁共振成像技术，探讨丙泊酚对人情绪记忆系统的影响。

在本次研究中，35位健康受试者被随机分为丙泊酚组（估算脑内浓度达到0.90μg/ml）和安慰剂对照组。在药物输注期间，获得血压-氧浓度水平依赖的活化反应的同时，提供情绪唤醒及大脑成像。在2小时的停药间期后，评估已成功编码项目的后续记忆。使用统计参数图进行成像分析并且使用行为检测模型进行行为分析。

丙泊酚并不影响杏仁核对情绪唤醒的反应，但是可造成海马反应的显著抑制。同时丙泊酚可导致记忆性能与杏仁核活化解偶联，但是其仍与海马后部区域（具有减少遗忘发生的作用）的活化相关。

 

本研究表明，镇静剂量的丙泊酚对杏仁核活化的抑制相对无效，但是可通过涉及海马低反应性的机制阻断情绪调控及造成遗忘。这些研究结果表明即便对相关事件的记忆减弱，杏仁核依赖的恐惧系统也许仍能保持其完整性。这也许对如创伤应急障碍等基于恐惧的精神病理学的围术期发展具有临床价值。

原始出处：

K.O.PryorJ.C.Root,M.Mehta,E.Stern,H.Pan,R.A. Veselis and D.A.Silbersweig. Effect of propofol on the medial temporal lobe emotionalmemory system: a functional magnetic resonanceimaging study in human subjects. Br J Anaesth. 2015 Jul 115.

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    2016-09-15 1e10c84am36(暂无匿称)

    文章不错，值得拜读

    0

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    2016-01-22 xiangyuzhou971

    #EST#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=127186, encodeId=376612e186f7, content=文章不错，值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 15 07:41:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050456, encodeId=d5762050456a2, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Jan 22 04:59:00 CST 2016, time=2016-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633324, encodeId=512a163332421, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Fri Jul 01 14:59:00 CST 2016, time=2016-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47990, encodeId=a5304e990cc, content=新理念, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 14:10:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35425, encodeId=03d4354259f, content=新概念, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b531630898, createdName=pine007, createdTime=Tue Aug 11 11:47:00 CST 2015, time=2015-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540389, encodeId=0d7c154038974, content=<a href='/topic/show?id=48d6614666b' target=_blank style='color:#2F92EE;'>#杏仁核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61466, encryptionId=48d6614666b, topicName=杏仁核)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53c913230719, createdName=paperyu, createdTime=Sat Aug 08 09:59:00 CST 2015, time=2015-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35196, encodeId=687e3519617, content=期待有更多的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Fri Aug 07 16:19:00 CST 2015, time=2015-08-07, status=1, ipAttribution=)]
    2016-07-01 AspirantSuo

    #ANA#

    0

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    2015-12-26 hixiaoluo

    新理念

    0

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    2015-08-11 pine007

    新概念

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=127186, encodeId=376612e186f7, content=文章不错，值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 15 07:41:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050456, encodeId=d5762050456a2, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Jan 22 04:59:00 CST 2016, time=2016-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633324, encodeId=512a163332421, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Fri Jul 01 14:59:00 CST 2016, time=2016-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47990, encodeId=a5304e990cc, content=新理念, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 14:10:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35425, encodeId=03d4354259f, content=新概念, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b531630898, createdName=pine007, createdTime=Tue Aug 11 11:47:00 CST 2015, time=2015-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540389, encodeId=0d7c154038974, content=<a href='/topic/show?id=48d6614666b' target=_blank style='color:#2F92EE;'>#杏仁核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61466, encryptionId=48d6614666b, topicName=杏仁核)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53c913230719, createdName=paperyu, createdTime=Sat Aug 08 09:59:00 CST 2015, time=2015-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35196, encodeId=687e3519617, content=期待有更多的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Fri Aug 07 16:19:00 CST 2015, time=2015-08-07, status=1, ipAttribution=)]
    2015-08-08 paperyu

    #杏仁核#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=127186, encodeId=376612e186f7, content=文章不错，值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Sep 15 07:41:00 CST 2016, time=2016-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050456, encodeId=d5762050456a2, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Fri Jan 22 04:59:00 CST 2016, time=2016-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633324, encodeId=512a163332421, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Fri Jul 01 14:59:00 CST 2016, time=2016-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47990, encodeId=a5304e990cc, content=新理念, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 14:10:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35425, encodeId=03d4354259f, content=新概念, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b531630898, createdName=pine007, createdTime=Tue Aug 11 11:47:00 CST 2015, time=2015-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540389, encodeId=0d7c154038974, content=<a href='/topic/show?id=48d6614666b' target=_blank style='color:#2F92EE;'>#杏仁核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61466, encryptionId=48d6614666b, topicName=杏仁核)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53c913230719, createdName=paperyu, createdTime=Sat Aug 08 09:59:00 CST 2015, time=2015-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35196, encodeId=687e3519617, content=期待有更多的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Fri Aug 07 16:19:00 CST 2015, time=2015-08-07, status=1, ipAttribution=)]
    2015-08-07 hlycom3356

    期待有更多的研究

    0