J Stroke:前循环缺血性脑卒中的患者在急性再灌注治疗前血压与柔脑膜动脉侧支循环状态的相关性

2017-07-31 shaosai MedSci原创

柔脑膜侧支循环在急性动脉闭塞的患者中维持这血液供应,但其作用在不同动脉血压(ABP)的个体间是有差异的。本研究旨在评估急性缺血性脑卒中患者ABP和由CT灌注评估的侧支循环之间的相关性,并将结果发表在J Stroke上。

柔脑膜侧支循环在急性动脉闭塞的患者中维持这血液供应,但其作用在不同动脉血压(ABP)的个体间是有差异的。本研究旨在评估急性缺血性脑卒中患者ABP和由CT灌注评估的侧支循环之间的相关性,并将结果发表在J Stroke上。

本研究回顾性分析了自2009年至2014年前循环缺血性脑卒中并行CT灌注的患者。使用相对充盈时间延迟(rFTD)来评估侧支循环状态,rFTD指在外侧裂经侧支循环来源的造影剂到达的延迟时间,从0秒开始。使用零膨胀负二项式回归模型对数据进行分析。关于狭窄位置及发病到CT检查时间(OCT)该统计模型中包括可能的交互检验。

结果为,本研究共纳入了270例患者。研究发现,对于患者rFTD为0的患者,收缩压(SBP)每增长10mmHg, 胜算增加27.9% (p=0.001),而舒张压(DBP)每增长10mmHg, 胜算增加73.9%( p<0.001),平均血压(MBP)每增长10mmHg, 胜算增加68.5% ( p<0.001);而对于rFTD并不为0的患者,收缩压(SBP)、DBP、MBP每增长10mmHg,相应rFTD约减低分别为7%、10% 、 11%,在BP-rFTD模型中,狭窄位置与OCT之间并无明显交互作用。

本研究表明,在急性缺血性脑卒中患者中,通过减小的rFTD提示ABP越高,柔脑膜侧支循环功能越好,两者具有相关性。

原始出处:

Jiang B, Churilov L, Kanesan L, et al,Blood Pressure May Be Associated with Arterial Collateralization in Anterior Circulation Ischemic Stroke before Acute Reperfusion Therapy. J Stroke. 2017.DOI: 10.5853/jos.2016.01739

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2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228654, encodeId=bc5722865490, content=有意思,涨姿势了, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Tue Aug 01 07:10:07 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228633, encodeId=75e6228633ea, content=阅读了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Tue Aug 01 06:02:58 CST 2017, time=2017-08-01, status=1, ipAttribution=)]
    2017-08-04 周周人

    学习。

    0

  5. 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  6. 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GetPortalCommentsPageByObjectIdResponse(id=1489074, encodeId=127914890e402, content=<a href='/topic/show?id=7b2130649c9' target=_blank style='color:#2F92EE;'>#再灌注治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30649, encryptionId=7b2130649c9, topicName=再灌注治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e33a8492666, createdName=xjy05, createdTime=Wed Aug 02 14:18:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228922, encodeId=4bdc228922c8, content=进一步学习了~, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Tue Aug 01 21:13:36 CST 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  7. 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2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228654, encodeId=bc5722865490, content=有意思,涨姿势了, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Tue Aug 01 07:10:07 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228633, encodeId=75e6228633ea, content=阅读了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Tue Aug 01 06:02:58 CST 2017, time=2017-08-01, status=1, ipAttribution=)]
    2017-08-01 QQ25ed180f

    进一步学习了~

    0

  8. 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2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228654, encodeId=bc5722865490, content=有意思,涨姿势了, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Tue Aug 01 07:10:07 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228633, encodeId=75e6228633ea, content=阅读了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, 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    2017-08-01 baihao215

    有意思,涨姿势了

    0

  9. 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createdBy=8fd71930726, createdName=半夏微凉, createdTime=Tue Aug 01 06:02:58 CST 2017, time=2017-08-01, status=1, ipAttribution=)]
    2017-08-01 半夏微凉

    阅读了谢谢分享

    0

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