Stroke:急性缺血性脑卒中患者**嗜酸性粒细胞计数和复杂主动脉弓斑块有啥关系?

2017-02-28 xing.T MedSci原创

由此可见,在急性缺血性脑卒中患者中,血液中绝对嗜酸性粒细胞计数的增加与复杂主动脉弓斑块的存在独立相关。该研究的结果表明血液中绝对嗜酸性粒细胞计数可能是急性缺血性脑卒中患者存在复杂主动脉弓斑块的一个有用的预测因素。

嗜酸性粒细胞计数被认为是与动脉粥样硬化和主动脉弓斑块形成相关。然而,在急性缺血性卒中患者中这些相关性是否存在仍不清楚。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员的目的是评估急性缺血性卒中患者血液中绝对嗜酸性粒细胞计数与患者主动脉弓斑块之间的相关性。

在该研究中,研究人员对连续就诊的接受了经食道超声心动图检查的急性缺血性脑卒中患者进行回顾性分析。研究人员将该研究中的复杂主动脉弓斑块定义为斑块厚度≥4毫米,伴有溃疡,或移动性成分。

该研究共纳入了430例急性缺血性卒中患者(289例患者为男性,平均年龄为69.8±11.4岁)。研究人员发现相比于没有复杂主动脉弓斑块的患者,存在复杂主动脉弓斑块患者(n=169例)血液中绝对嗜酸性粒细胞计数较高(167±174个/µL vs. 127±127 /µL;P=0.007)。多因素分析显示患者增加的绝对嗜酸性粒细胞计数与复杂主动脉弓斑块之间存在独立相关(比值比为2.09;95%可信区间为1.21-3.65)。

由此可见,在急性缺血性脑卒中患者中,血液中绝对嗜酸性粒细胞计数的增加与复杂主动脉弓斑块的存在独立相关。该研究的结果表明血液中绝对嗜酸性粒细胞计数可能是急性缺血性脑卒中患者存在复杂主动脉弓斑块的一个有用的预测因素。         

原始出处:

Takaya Kitano, et al. Association Between Absolute Eosinophil Count and Complex Aortic Arch Plaque in Patients With Acute Ischemic Stroke.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.116.016436

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encodeId=817518182314, content=急性缺血性脑卒中患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Mar 22 07:09:12 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181313, encodeId=2e661813138e, content=急性缺血性脑卒中的发病机制。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Mar 20 07:05:05 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180234, encodeId=6b381802348b, content=急性缺血性脑卒中患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 16 07:23:34 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-04-19 jyzxjiangqin

    急性缺血性脑卒中患者发病因素。

    0

  5. 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encodeId=6b381802348b, content=急性缺血性脑卒中患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 16 07:23:34 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-04-08 jyzxjiangqin

    急性缺血性脑卒中患者绝对嗜酸粒细胞的计数。

    0

  6. 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  7. 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encodeId=6b381802348b, content=急性缺血性脑卒中患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 16 07:23:34 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-03-30 jyzxjiangqin

    急性缺血性脑卒中患者的发病因素。

    0

  8. 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encodeId=817518182314, content=急性缺血性脑卒中患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Mar 22 07:09:12 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181313, encodeId=2e661813138e, content=急性缺血性脑卒中的发病机制。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Mon Mar 20 07:05:05 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180234, encodeId=6b381802348b, content=急性缺血性脑卒中患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 16 07:23:34 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-03-22 jyzxjiangqin

    急性缺血性脑卒中患者。

    0

  9. 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encodeId=6b381802348b, content=急性缺血性脑卒中患者。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 16 07:23:34 CST 2017, time=2017-03-16, status=1, ipAttribution=)]
    2017-03-20 jyzxjiangqin

    急性缺血性脑卒中的发病机制。

    0

  10. 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    2017-03-16 jyzxjiangqin

    急性缺血性脑卒中患者。

    0

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急性缺血性脑卒中患者经常出现大血管闭塞,而机械取栓(Mechanical thrombectomy,MT)改善了急性缺血性脑卒中(AIS)患者的临床结局。然而不知道静脉溶栓(IVT)对MT患者是否有益。最近发表在JAMA Neurol上的一项研究探讨了在MT(支架取栓)之前进行IVT治疗是否有益。这是一项事后分析,使用的数据来自291例机械取栓的病人,这些患者来自2个大的多中心的前瞻性评价AIS患

Stroke:急性缺血性脑卒中的血管内治疗可减少梗死体积

急性缺血性脑卒中再灌注治疗的目的是限制脑梗死。本研究的目的是探讨血管内治疗对功能性结果的有利效果,有益效果可以解释为减少治疗后梗死体积。ESCAPE试验是一项多中心,随机双盲与结果评估开放性试验。在招募的315人中(血管内治疗n=165;对照组n=150),314例患者的梗死体积在24至48小时(n=254)接受了磁共振成像或计算机断层扫描(n=60)进行测量。治疗后梗死体积通过治疗分配和再通/再

JAHA:急性缺血性脑卒中患者语言偏好与静脉溶栓的关系

结论与研究假设相反,一旦考虑初始卒中严重程度,在急性缺血性卒中患者中偏好说非英语语言与较低的静脉溶栓率无关。

JACC:急性缺血性脑卒中患者机械取栓治疗可降低全因死亡率

急性缺血性脑卒中是世界范围内严重的伤残和死亡的主要原因。个体的随机临床试验显示,在急性缺血性卒中患者的治疗管理中,常规护理后进行机械取栓,与单独常规治疗(即静脉溶栓)相比,可能会为患者带来好处。本研究的目的是系统地确定,如果常规治疗后进行机械取栓是否会为大动脉闭塞引起的急性缺血性脑卒中患者带来更好的预后。研究人员进行了比较常规治疗后机械取栓与单纯常规治疗急性缺血性中风的随机试验。随机效应的总风险比

JAMA:血管内血栓切除术治疗急性缺血性脑卒中——Meta分析

关于血管内治疗的试验研究其效果各异,而且需要进一步的定义亚组之间血管内介入治疗的效果。本研究旨在探究急性缺血性脑卒中患者血管内机械性取栓与临床结果之间的关系。

NEJM:急性缺血性脑卒中,低剂量阿替普酶的治疗效果并不差于标准剂量

NEJM:急性缺血性脑卒中,低剂量阿替普酶的治疗效果并不差于标准剂量的治疗效果使用低于标准剂量的阿替普酶对急性缺血性脑卒中进行溶栓治疗可以改善脑出血的结局,还可降低脑出血的风险。采用2*2准因子开放标签设计,随机分配了3310名符合溶栓治疗的患者(中位年龄为67岁; 63%为亚洲人),分别接受低剂量的阿替普酶治疗(0.6 mg/kg)和标准剂量治疗(0.9 mg/kg);随机分组是在患者急性缺血性