Neurology:低血糖增加慢性肾脏疾病患者的卒中风险

2014-07-31 佚名 丁香园

既往研究显示慢性肾脏疾病(CKD)患者低血糖发生率增加,而低血糖与许多疾病心血管并发症风险增加相关,例如冠心病,充血性心力衰竭(CHF),卒中以及死亡等。然而,CKD 患者中低血糖对于心血管并发症的影响尚不明确。为此,来自台湾的 Chia-Hung Kao 等学者进行了一项研究,旨在明确低血糖对于慢性肾脏疾病(CKD)患者心血管预后的影响。研究发现复发性低血糖的 CKD 患者卒中和死亡风险明显增加

既往研究显示慢性肾脏疾病(CKD)患者低血糖发生率增加,而低血糖与许多疾病心血管并发症风险增加相关,例如冠心病,充血性心力衰竭(CHF),卒中以及死亡等。然而,CKD 患者中低血糖对于心血管并发症的影响尚不明确。

为此,来自台湾的 Chia-Hung Kao 等学者进行了一项研究,旨在明确低血糖对于慢性肾脏疾病(CKD)患者心血管预后的影响。研究发现复发性低血糖的 CKD 患者卒中和死亡风险明显增加,该研究发表于新一期的 Neurology 杂志中。

该研究受试者的信息来自于 1998 年 -2008 年台湾全民医疗保险数据库。研究者对伴或不伴低血糖的 CKD 的患者进行了该项回顾性队列研究,评估这两组 CKD 患者中总体死亡率以及包括卒中,冠心病以及充血性心力衰竭等疾病在内的心脑血管并发症。

该研究最终纳入了 46,135 例 CKD 患者,其中 2,117 例 (4.59%) 患者发生了低血糖,并住院治疗。多元 Cox 风险比例回归分析显示卒中,冠心病,充血性心衰和死亡均与 CKD 患者低血糖相关(风险比 HR 分别为 1.62,1.25,1.49,2.53)。

低血糖复发与死亡风险增加显著相关(HR 为 33.0),而其他的多种心血管事件也有类似的趋势。与无低血糖患者相比,发生低血糖的 CKD 患者其卒中风险和总体死亡率增加,不管这些患者是否有糖尿病。

该研究的结论认为,在低血糖的患者中,CKD 与卒中风险和死亡率增加相关。复发性低血糖相当程度上增加卒中和总体死亡风险。这些研究结果表明低血糖在 CKD 患者卒中和死亡中发挥关键的作用。

原始出处:


Yu TM1, Lin CL1, Chang SN1, Sung FC1, Kao CH2.Increased risk of stroke in patients with chronic kidney disease after recurrent hypoglycemia.Neurology. 2014 Jul 16. pii: 10.1212/WNL.0000000000000711. [Epub ahead of print]

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    2015-08-04 sundong

    血糖要控制好

    0

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    2014-11-21 yinhl1978
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    2014-08-03 112.133.29.144

    低血糖风险看来值得研究

    0

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