Lancet Diabetes Endo:孕前肥胖与早产

2019-08-07 MedSci MedSci原创

孕前肥胖与早产的风险显著相关,但其风险受年龄和种族差异的影响

孕前肥胖与早产之间的关系尚存在争议,近日研究人员就孕前肥胖与早产之间的关系进行系统研究。

研究人员利用美国国家生命统计系统2016年和2017年的全国出生证明数据,进行这项基于人口的队列研究。怀孕前肥胖被定义为怀孕前体重指数(BMI)至少为30 kg/m 2,早产被定义为小于37周的胎龄。研究人员采用Logistic回归模型,对产妇年龄、种族或族裔、胎次、受教育程度、孕期吸烟情况、早产史、婚姻状况、婴儿性别和产前护理开始时间进行调整,以估计早产的优势比(OR)。

研究人员分析了7141630例单胎活产,其中527637例(7.4%)为早产。西班牙裔产妇127611人(7.5%),非西班牙裔白人产妇244 578人(6.6%),非西班牙裔黑人产妇102509人(10.4%)有早产。在整个人群中,孕妇怀孕前肥胖与早产风险显著相关(BMI为18.5-24.9 kg/m 2;调整OR 1.18)。在非西班牙裔白人产妇中,20岁以下的孕妇肥胖与早产呈负相关(调整后的OR 0.92),但与20岁或以上的早产呈正相关(25~29岁,30~34岁,35~39岁,≥40岁分别为1.04、1.20、1.34、1.40和1.39)。在西班牙裔妇女中,20岁以下的孕妇肥胖与早产无关(0.98),但20岁或以上的产妇与早产有积极的关联(20-24岁、25-29岁、30-34岁、35-39岁和40岁以上人群分别为1.06、1.21、1.32、1.38和1.30)。在非西班牙裔黑人妇女中,30岁以下母亲肥胖与儿童的早产成负相关(20岁以下为0.76,20-24岁为0.83,25-29岁为0.98), 但与30岁或30岁以上产妇早产呈正相关(30-34岁、35-39岁和40岁以上人群分别为1.15、1.26和1.29)。

研究认为,孕前肥胖与早产的风险显著相关,但其风险受年龄和种族差异的影响。

原始出处:


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    2019-11-23 szhvet
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    2019-10-06 howi