Diabetologia:糖尿病患者的发生卒中风险的性别差异

2014-06-03 MedSci MedSci原创

很多大血管事件都存在性别差异,如卒中等。但糖尿病患者中卒中发生情况并不清楚。研究者前瞻性选择了10876位男性和19278位女性糖尿病患者,比较它们的糖化血红蛋白水平以及卒中的差异。通过6.7年的随访观察,2949例患者发生了卒中,多元回归分析校正发现,不同基线水平的HbA(1c)存在差异。以HbA(1c) 6.0-6.9% [42-52 mmol/mol]为参考组,<6.0%,7.0-7.

很多大血管事件都存在性别差异,如卒中等。但糖尿病患者中卒中发生情况并不清楚。研究者前瞻性选择了10876位男性和19278位女性糖尿病患者,比较它们的糖化血红蛋白水平以及卒中的差异。

通过6.7年的随访观察,2949例患者发生了卒中,多元回归分析校正发现,不同基线水平的HbA(1c)存在差异。以HbA(1c) 6.0-6.9% [42-52 mmol/mol]为参考组,<6.0%,7.0-7.9%, 8.0-8.9%, 9.0-9.9%, ≥10.0%的HR分别,在男性为0.96 (95% CI 0.80, 1.14), 1.04 (0.85, 1.28), 1.11 (0.89, 1.39), 1.10 (0.86, 1.41) and 1.22 (0.92, 1.35) (p for trend = 0.66) ;在女性中分别为 1.03 (0.90, 1.18), 1.09 (0.94, 1.26), 1.19 (1.00, 1.42), 1.32 (1.09, 1.59) and 1.42 (1.23, 1.65) (p for trend <0.001) .通过民族进行分层,无论是否使用降糖药物,仍然呈现男女性的差异。这些研究结果显示,在女性糖尿病患者中HbA1c和卒中事件的发生更高,而且,大于55岁的糖尿病女性患者中血糖控制差会更为明显。

原始出处:


Zhao W, Katzmarzyk PT, Horswell R, Wang Y, Johnson J, Hu G.Sex differences in the risk of stroke and HbA(1c) among diabetic patients.Diabetologia. 2014 May;57(5):918-26

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    2015-04-11 x35042875

    国真实妊娠糖尿病患病率应该在这两种方案得到的患病率之间

    0

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    2014-12-05 智智灵药
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    2014-06-03 lovetcm

    这是大样本,长期随访的结果,相当可信

    0

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