Neurology:特发性颅内压增高的临床表现与嗅觉障碍程度相关

2013-07-03 sunight dxy

特发性颅内压增高(Idiopathic intracranial hypertension, IIH)是没有临床,实验室及影像学证据显示有颅内病变的颅内压增高,其往往出现嗅觉异常。尽管越来越多的证据显示在特发性颅内压增高患者中脑脊液系统功能异常或可引起嗅觉障碍,但至今特发性颅内压增高患者的嗅觉异常处于什么水平尚缺乏客观的证据。来自德国的Hagen Kunte等学者研究了特发性颅内压增高患者的嗅觉异

特发性颅内压增高(Idiopathic intracranial hypertension, IIH)是没有临床,实验室及影像学证据显示有颅内病变的颅内压增高,其往往出现嗅觉异常。尽管越来越多的证据显示在特发性颅内压增高患者中脑脊液系统功能异常或可引起嗅觉障碍,但至今特发性颅内压增高患者的嗅觉异常处于什么水平尚缺乏客观的证据。来自德国的Hagen Kunte等学者研究了特发性颅内压增高患者的嗅觉异常情况,在线发表在2013年6月24日的Neurology杂志上,结果显示:特发性颅内压患者临床表现与嗅觉障碍程度相关。
该研究共纳入17例特发性颅内压增高的患者,通过年龄和性别配比17例对照者。使用扩展的嗅棒(注:嗅棒(Sniffin’ Sticks),由3套分别反映气味识别、气味阈值及气味鉴别能力的水笔组成,每套有16只水笔,总分48分,得分越高,嗅觉越好。)检测TDI嗅觉系统,即嗅觉阈值、气味辨别和气味区分。
嗅觉检测的特发性颅内压增高患者TDI平均(四分位值)得分降低,为29分(26.5–35.5),对照组患者得分为35分(34–37),p = 0.003。进一步采用Spearman等级相关显示IIH患者TDI得分的下降与近期的临床症状恶化相关(r = 0.66, p = 0.004)。
该探索性研究显示特发性颅内压增高的患者出现嗅觉障碍,特别是在最新诊断或出现临床症状恶化的患者中下降明显。

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    2013-07-05 yinhl1978
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    2013-07-05 liuxiaona
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    2013-07-05 liuxiaona

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