JAMA Oncology：术前和术后CEA水平与结肠癌预后的关系

2017-12-22 MedSci MedSci原创

临床指南建议检测结肠癌术前CEA水平。术后CEA水平持续升高与肿瘤转移风险增加有关，但是术前升高术后正常的CEA水平的预后作用尚不清楚。JAMA Oncology近期发表了一篇文章，研究术前CEA水平高，术后降至正常的患者是否比术前CEA水平正常的患者复发风险更高。

临床指南建议检测结肠癌术前CEA水平。术后CEA水平持续升高与肿瘤转移风险增加有关，但是术前升高术后正常的CEA水平的预后作用尚不清楚。JAMA Oncology近期发表了一篇文章，研究术前CEA水平高，术后降至正常的患者是否比术前CEA水平正常的患者复发风险更高。

研究纳入了2007年至2014年间接受根治性手术切除的Ⅰ-Ⅲ期结肠癌患者。患者根据CEA情况分为3组：术前CEA水平正常，术前升高但术后CEA水平正常，术前和术后CEA水平均正常。主要的研究结果为3年无复发生存情况。最终共纳入1027例患者，461例男性，中位年龄64岁。术前CEA水平正常的患者比术前CEA水平升高的两组联合患者3年无复发生存高7.4%，但与术后CEA水平正常的患者无复发生存情况相似。术后CEA水平升高的患者比术后CEA水平正常的两组患者无复发生存差14.9%。多因素分析表明术后CEA水平增加是无复发生存不佳的独立预后因素，而术后正常CEA水平无此效果。

文章最后认为，术前CEA水平上升术后正常并不是不良预后的指标。需要常规检测术后CEA水平。术后CEA水平升高的患者复发风险增加，尤其是在术后的12个月内。

原始出处：

Tsuyoshi Konishi,Yoshifumi Shimada,et al.Association of Preoperative and Postoperative Serum Carcinoembryonic Antigen and Colon Cancer Outcome.JAMA Oncol.December 2017 doi:10.1001/jamaoncol.2017.4420

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2018-11-09 circumcision

#Oncology#

30 0
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2018-07-27 minlingfeng

#Oncol#

26 0
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2017-12-24 大爰

学习并分享!!

57 0
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2017-12-24 shizhenshan

#CEA#

0 0
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2017-12-23 sunfeifeiyang

阅

60 0
[GetPortalCommentsPageByObjectIdResponse(id=1674436, encodeId=2ab216e443627, content=<a href='/topic/show?id=e8aa13359b1' target=_blank style='color:#2F92EE;'>#Oncology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13359, encryptionId=e8aa13359b1, topicName=Oncology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb7226973259, createdName=circumcision, createdTime=Fri Nov 09 07:00:00 CST 2018, time=2018-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865247, encodeId=08f3186524ef2, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jul 27 23:00:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272142, encodeId=14742e21422b, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Dec 24 13:25:37 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488636, encodeId=7109148863657, content=<a href='/topic/show?id=c6af443e2d' target=_blank style='color:#2F92EE;'>#CEA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4437, encryptionId=c6af443e2d, topicName=CEA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce258462097, createdName=shizhenshan, createdTime=Sun Dec 24 01:00:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271890, encodeId=4f102e1890e2, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Dec 23 17:54:34 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271885, encodeId=11722e1885d0, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Sat Dec 23 17:51:30 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271776, encodeId=27582e1776da, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Dec 23 09:49:09 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271490, encodeId=70292e149092, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Dec 22 10:36:19 CST 2017, time=2017-12-22, status=1, ipAttribution=)]
2017-12-23 神功盖世

阅

58 0
[GetPortalCommentsPageByObjectIdResponse(id=1674436, encodeId=2ab216e443627, content=<a href='/topic/show?id=e8aa13359b1' target=_blank style='color:#2F92EE;'>#Oncology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13359, encryptionId=e8aa13359b1, topicName=Oncology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb7226973259, createdName=circumcision, createdTime=Fri Nov 09 07:00:00 CST 2018, time=2018-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865247, encodeId=08f3186524ef2, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jul 27 23:00:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272142, encodeId=14742e21422b, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Dec 24 13:25:37 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488636, encodeId=7109148863657, content=<a href='/topic/show?id=c6af443e2d' target=_blank style='color:#2F92EE;'>#CEA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4437, encryptionId=c6af443e2d, topicName=CEA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce258462097, createdName=shizhenshan, createdTime=Sun Dec 24 01:00:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271890, encodeId=4f102e1890e2, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Dec 23 17:54:34 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271885, encodeId=11722e1885d0, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Sat Dec 23 17:51:30 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271776, encodeId=27582e1776da, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Dec 23 09:49:09 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271490, encodeId=70292e149092, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋，懒，贪, createdTime=Fri Dec 22 10:36:19 CST 2017, time=2017-12-22, status=1, ipAttribution=)]
2017-12-23 大爰

学习了谢谢分享!!

61 0
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2017-12-22 戒馋，懒，贪

谢谢分享学习了

55 0

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