PLoS Pathogens:清华大学程功团队从蚊虫肠道菌中发现一类新型广谱抗病毒蛋白

2022-06-11 清华大学医学院 网络

以上工作为开发新型虫媒病毒传播控制策略和抗虫媒病毒药物研发提供了新思路。

2022年6月9日,清华大学医学院程功课题组在《科学公共图书馆·病原学》(PLoS Pathogens)杂志在线刊登了题为《蚊虫肠道细菌分泌型脂酶可有效抑制虫媒病毒传播》(Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes)的最新研究成果。

虫媒病毒可由节肢动物传播并导致严重人类疾病,其主要分布于披膜病毒科、黄病毒科、呼肠孤病毒科和布尼亚病毒目。虫媒病毒可导致出血热、关节炎、脑炎和脑膜炎等严重临床症状,并导致较高死亡率。虫媒病毒在世界范围内的广泛传播,为全世界的公共卫生安全防控带来严峻挑战。尽管针对某些虫媒病毒(例如乙型脑炎病毒和黄热病病毒)已经开发出了有效疫苗,目前大多数虫媒病毒还没有特效的药物或保护性疫苗。因此,亟需研发针对广谱抗虫媒病毒策略的研究,为控制虫媒病毒的传播和流行提供新的解决方案。

该研究中,通过对具有抗病毒活性的一种蚊虫肠道共生菌(色素杆菌北京株,Chromobacterium sp. Beijing)的分泌型蛋白进行功能筛选,发现鉴定了一类具有脂酶活性的抗病毒蛋白(CbAE-1和CbAE-2),该类蛋白可有效抑制如登革病毒、寨卡病毒、乙型脑炎病毒、黄热病病毒和辛德比斯病毒等虫媒病毒的感染。进一步机理研究表明,CbAE-1和CbAE-2通过其脂酶活性,直接破坏病毒包膜结构导致其失活。

另一方面,由于CbAEs可直接调节蚊虫的病毒感染率和生存率,这为通过基因工程改造技术,研发基于蚊虫共菌群的虫媒病毒的控制策略提供了一种新的选择。以上工作为开发新型虫媒病毒传播控制策略和抗虫媒病毒药物研发提供了新思路。

清华大学医学院程功教授为论文的通讯作者;清华大学医学院2016级博士生余茜、童良琴和2019级博士生张礼铭为论文的并列第一作者;来自美国康涅狄格大学医学院王朋华教授和清华大学医学院助理研究员朱毅斌博士为本论文合作者。该研究获国家自然科学基金基础科学中心、国家自然科学基金委杰出青年基金、国家自然科学基金委重点项目、科技部国家重点研发计划、清华大学春风基金、云南省专家工作站基金等基金的联合资助。

原文链接:

Yu X, Tong L, Zhang L, Yang Y, Xiao X, Zhu Y, Wang P, Cheng G.Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes.PLoS Pathog (IF: 6.82Q1). 2022 Jun 9;18(6):e1010552

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    2022-07-17 cnxcy
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    2022-06-13 yahu
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    2022-06-13 医生2397

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