Ann Intern Med:坐骨神经痛患者硬膜外皮质类固醇注射仅具短效

2012-11-23 高晓方 编译 中国医学论坛报

  澳大利亚和新西兰联合研究表明,硬膜外皮质类固醇注射仅能短期缓解坐骨神经痛患者的腿痛和失能。论文11月13日在线发表于《内科学年鉴》(Ann Intern Med)。     研究者检索了PsycINFO、MEDLINE、EMBASE等数据库,选取评估坐骨神经痛患者接受硬膜外皮质类固醇注射疗效的随机对照试验23项。将腿痛、背痛和失能转化为0(无疼痛或失能)~100(疼痛或失

  澳大利亚和新西兰联合研究表明,硬膜外皮质类固醇注射仅能短期缓解坐骨神经痛患者的腿痛和失能。论文11月13日在线发表于《内科学年鉴》(Ann Intern Med)。  

  研究者检索了PsycINFO、MEDLINE、EMBASE等数据库,选取评估坐骨神经痛患者接受硬膜外皮质类固醇注射疗效的随机对照试验23项。将腿痛、背痛和失能转化为0(无疼痛或失能)~100(疼痛或失能最严重)评分,并将具临床意义的分值变化定义为10~30分,评估短期(>2周但≤3个月)和长期(≥12个月)随访疗效。  

  结果为,与安慰剂相比,硬膜外皮质类固醇注射对短期腿痛和失能具显著疗效,但改善程度较小;长期改善程度更低,且无统计学显著性。



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    2012-11-25 贵阳
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