J Am Soc Nephrol:请注意!口服抗生素可能增加肾结石风险

2018-05-12 周舟 新华网

发表在最新一期《美国肾脏病学会杂志》上的一项研究说,口服抗生素可能增加患肾结石风险,且对儿童和青少年影响尤为显著。


发表在最新一期《美国肾脏病学会杂志》上的一项研究说,口服抗生素可能增加患肾结石风险,且对儿童和青少年影响尤为显著。

论文作者之一、美国费城儿童医院泌尿科医生格里高利·塔西安说,过去30年中,肾结石发病率出现大幅增长,在青少年和年轻女性中尤其明显。

塔西安率领的医疗团队调查了1994年到2015年间英国超过1300万人的健康档案,找到了对患肾结石前使用过抗生素的约2.6万人,将他们与另外26万人进行了对比分析,结果发现五类常见口服抗生素与肾结石有关,分别是磺胺、头孢菌素、氟喹诺酮、呋喃妥英和青霉素。

结果发现,使用磺胺类药物的人群患肾结石风险是未使用抗生素者的两倍以上,青霉素使用者的患病风险则增加了27%。

研究人员认为,使用抗生素改变了人体内特别是肠道和泌尿系统的微生物群落,可能与引发肾结石有关。

研究显示,使用抗生素后的几年内患肾结石的风险最大,然后随着时间推移而减少。专家建议应谨慎服用抗生素,特别是儿童和青少年。

原始出处:

Gregory E. Tasian, et al.Oral Antibiotic Exposure and Kidney Stone Disease.JASN ASN.2017111213; published ahead of print May 10, 2018, doi:10.1681/ASN.2017111213

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1417316, encodeId=bccd141e31661, content=<a href='/topic/show?id=625a3821ebe' target=_blank style='color:#2F92EE;'>#口服抗生素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38217, encryptionId=625a3821ebe, topicName=口服抗生素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89f83256788, createdName=dinorsor525, createdTime=Mon May 14 06:35:00 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314528, encodeId=3cf8314528c6, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat May 12 22:15:04 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314498, encodeId=c24f314498e4, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat May 12 19:25:52 CST 2018, time=2018-05-12, status=1, ipAttribution=)]
    2018-05-12 changjiu

    学习一下谢谢

    0

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    2018-05-12 131****1460

    学习了受益匪浅

    0

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