J Aller Cl Imm-Pract:腹部内脏肥胖对成人哮喘症状的影响

2018-11-24 xing.T MedSci原创

由此可见,无论性别如何,腹部内脏脂肪与哮喘生活质量降低有关,与其他肥胖指数无关,这可能是由腹部内脏脂肪对预测的FEV1%降低以及GERD和抑郁风险增加的影响所致。因此,与任何其他肥胖指数相比,内脏肥胖可能对哮喘症状具有更多的临床影响。

以前的研究表明人体测量指标与哮喘症状较差有关,尤其是女性。然而,内脏肥胖对哮喘症状的潜在影响尚未得到很好的研究。近日,过敏性疾病领域权威杂志Journal of Allergy and Clinical Immunology-In Practice上发表了一篇研究文章,在这项研究中,研究人员评估了内脏肥胖是否与成人哮喘不良的症状相关,而与人体测量指标和性别无关。如果出现这种关系,研究人员调查是否通过对肺功能和/或肥胖相关合并症的影响来解释。
 
研究人员分析了来自日本的206名哮喘患者的数据。除了人体测量指标(BMI和腰围)外,研究人员还通过计算机断层扫描(CT)扫描评估腹部内脏和皮下脂肪,并使用日本版的哮喘生活质量问卷(AQLQ)评估生活质量。
 
所有肥胖指数与女性哮喘生活质量降低呈负相关。然而,只有内脏脂肪区域与男性AQLQ呈显著负相关。只有腹部内脏脂肪与较高的食管反流病(GERD)和抑郁评分有关。虽然所有肥胖指数均显示与功能残余容量呈负相关,但只有内脏脂肪面积与预测的FEV1%呈显著负相关,与其他肥胖指数无关。
 
由此可见,无论性别如何,腹部内脏脂肪与哮喘生活质量降低有关,与其他肥胖指数无关,这可能是由腹部内脏脂肪对预测的FEV1%降低以及GERD和抑郁风险增加的影响所致。因此,与任何其他肥胖指数相比,内脏肥胖可能对哮喘症状具有更多的临床影响。
 
原始出处:
 
Houman Goudarzi,et et al.Impact of  of abdominal visceral adiposity on adult asthma symptoms. J Aller Cl Imm-Pract. 2018.https://doi.org/10.1016/j.jaip.2018.11.014
 
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    2018-12-11 13718711b3m

    学习了,非常好的临床学习资料,值得借鉴的临床经验,获益匪浅,感谢分享!

    0

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    2018-11-26 膀胱癌
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    2018-11-24 一个字-牛

    学习了谢谢分享

    0

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