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FEBS Open Bio：研究揭示转化生长因子-β抑制Npnt基因表达的机制

2018-05-18 MedSci MedSci原创

NpntFGF-2JNKPI3K
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Nephronectin（Npnt）是一种细胞外基质蛋白，是整合素α8β1的配体，参与各种器官，如肾、骨、肝和肌肉的发育。既往研究中，我们发现多种细胞因子可抑制Npnt的表达，包括转化生长因子-β（Tgf-β）和制瘤素M（Osm）。成纤维细胞生长因子（Fgf）-2，也称为基础Fgf，在骨骼发育和产后成骨中也起着重要作用。 在这项研究中，我们发现，在成骨细胞样细胞系MC3T3-E1细胞中，N

Nephronectin（Npnt）是一种细胞外基质蛋白，是整合素α8β1的配体，参与各种器官，如肾、骨、肝和肌肉的发育。既往研究中，我们发现多种细胞因子可抑制Npnt的表达，包括转化生长因子-β（Tgf-β）和制瘤素M（Osm）。成纤维细胞生长因子（Fgf）-2，也称为基础Fgf，在骨骼发育和产后成骨中也起着重要作用。

在这项研究中，我们发现，在成骨细胞样细胞系MC3T3-E1细胞中，Npnt的表达可被Fgf-2以剂量和时间依赖性方式抑制。此外，Fgf-2介导的Npnt mRNA的抑制涉及Jun N-末端激酶（JNK）和磷酸肌醇-3激酶（PI3K）通路。

总之，我们的结果表明，FGF-2通过JNK和PI3K通路抑制Npnt基因的表达。

原始出处：

Kato T, Yamada A, et al., FGF-2 suppresses expression of nephronectin via JNK and PI3K pathways. FEBS Open Bio. 2018 Apr 19;8(5):836-842. doi: 10.1002/2211-5463.12421. eCollection 2018 May.

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    2019-04-11 sunylz

    #Bio#

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    2018-11-07 feather89

    #PE#

    0

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    2019-01-14 sunylz

    #转化生长因子-β#

    0

  4. 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encryptionId=68d99328825, topicName=转化生长因子)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqTLTjicBiccpdUyHMGZV43nOBI6QIQqxVcy2EzXz67E390Q5j0R7QWjym391HxsyiaYt7NzbrcojRDw/132, createdBy=64462500151, createdName=ms705947299214030, createdTime=Mon Apr 15 20:25:00 CST 2019, time=2019-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348068, encodeId=7a1813480688d, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Sun May 20 14:25:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517996, encodeId=f8cd151e99679, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Sun May 20 14:25:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316501, encodeId=100c31650159, content=学习基础.分享一下., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/12/e4f539c3cf018a79ab5b42c44a3c40e4.jpg, createdBy=bf311615112, createdName=漩涡尽头, createdTime=Sat May 19 06:46:10 CST 2018, time=2018-05-19, status=1, ipAttribution=), 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createdTime=Sat May 19 04:55:46 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316433, encodeId=29d13164337b, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri May 18 23:34:48 CST 2018, time=2018-05-18, status=1, ipAttribution=)]
    2019-04-15 ms705947299214030

    #转化生长因子#

    0

  5. 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content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Sun May 20 14:25:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316501, encodeId=100c31650159, content=学习基础.分享一下., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/12/e4f539c3cf018a79ab5b42c44a3c40e4.jpg, createdBy=bf311615112, createdName=漩涡尽头, createdTime=Sat May 19 06:46:10 CST 2018, time=2018-05-19, status=1, ipAttribution=), 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createdTime=Sat May 19 04:55:46 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316433, encodeId=29d13164337b, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri May 18 23:34:48 CST 2018, time=2018-05-18, status=1, ipAttribution=)]
    2018-05-20 bioon1

    #基因表达#

    0

  6. 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content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Sun May 20 14:25:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316501, encodeId=100c31650159, content=学习基础.分享一下., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/12/e4f539c3cf018a79ab5b42c44a3c40e4.jpg, createdBy=bf311615112, createdName=漩涡尽头, createdTime=Sat May 19 06:46:10 CST 2018, time=2018-05-19, status=1, ipAttribution=), 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createdTime=Sat May 19 04:55:46 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316433, encodeId=29d13164337b, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri May 18 23:34:48 CST 2018, time=2018-05-18, status=1, ipAttribution=)]
    2018-05-20 12499e01m50暂无昵称

    #生长因子#

    0

  7. 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    2018-05-19 漩涡尽头

    学习基础.分享一下.

    0

  8. 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    2018-05-19 kafei

    学习一下谢谢

    0

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    2018-05-19 131****1460

    学习了受益匪浅

    0

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createdTime=Sat May 19 04:55:46 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316433, encodeId=29d13164337b, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri May 18 23:34:48 CST 2018, time=2018-05-18, status=1, ipAttribution=)]
    2018-05-18 清风拂面

    谢谢分享学习

    0

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