Stroke:缺血性卒中和卒中亚型早期血压对脑卒中后认知障碍的影响!

2018-06-12 xing.T MedSci原创

由此可见,缺血性卒中早期血压较低或较高均与3个月PSCI风险增加有关。维持收缩压/舒张压在143-158/93-102mmHg有助于减少PSCI的发生。而大动脉硬化亚型和前循环梗死亚型与3个月PSCI风险增加相关。

卒中早期血压控制以降低卒中后认知障碍(PSCI)的风险存在争议。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,该研究旨在探讨缺血性卒中和卒中亚型早期血压水平对PSCI的影响。

研究人员对七百九十六例急性缺血性脑卒中患者进行回顾性分析,并使用蒙特利尔认知评估对卒中发作后的认知功能进行评估。根据早期收缩压和舒张压水平的五分位数将患者分组。根据ORG10172急性脑卒中治疗分类(梗塞原因)和OxFord夏尔社区卒中项目分类(梗死部位)试验进行亚型分析。

在调整多个变量后,与中间五分位数(Q3,143-158mmHg)相比,3个月时收缩压最低(Q1,102-127mmHg)与最高(Q5,171-215mmHg)五分位数与PSCI风险增加(Q1比值比为1.83,95%可信区间为1.64-2.28;P=0.007;Q5比值比为2.32,95%可信区间为1.74-2.90;P<0.001)。在舒张压的五分位数中也发现了类似的联系。脑梗塞亚型分析表明,大动脉硬化和前循环梗死在多变量调整后与3个月PSCI风险增加相关(大动脉硬化比值比为1.42;95%可信区间为1.06-1.90;P=0.031;前循环梗死比值比为1.68;95%可信区间为1.32-2.15;P=0.001)。

由此可见,缺血性卒中早期血压较低或较高均与3个月PSCI风险增加有关。维持收缩压/舒张压在143-158/93-102mmHg有助于减少PSCI的发生。而大动脉硬化亚型和前循环梗死亚型与3个月PSCI风险增加相关。

原始出处:

Mingli He,et al.Effects of Blood Pressure in the Early Phase of Ischemic Stroke and Stroke Subtype on Poststroke Cognitive Impairment.Stroke. 2018. https://doi.org/10.1161/STROKEAHA.118.020827

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    2018-06-14 输赢

    我想问下血压的控制是怎么判定随访的?

    0

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    2018-06-13 changjiu

    谢谢分享学习

    0

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    2018-06-12 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

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    2018-06-12 smartxiuxiu

    0

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