J Thromb Haemost:超重和肥胖与复发性静脉血栓形成有关吗?

2017-05-30 xing.T MedSci原创

研究人员发现超重与复发性静脉血栓形成之间并不存在相关性。测量BMI并不是一个有用的工具,以确定复发性静脉血栓形成高风险的患者。

针对超重的患者复发性静脉血栓形成风险的研究得到了相互矛盾的结果。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员旨在估计超重是否会增加复发性静脉血栓形成的风险。

研究人员纳入了3889例患者,其首次静脉血栓形成后随访的中位数为5.6年。身体质量指数(BMI)通过体重/身高平方来计算,并根据预先定义的类别进行分类(正常体重、超重和肥胖),以及进行百分位数排列。研究人员估计了各组复发性静脉血栓形成的粗略发病率与95%可信区间(CI),并在调整年龄和性别后,采用Cox回归模型将各组结果进行比较。

复发性静脉血栓形成的发生率为3.3例/100人每年。相比于正常体重参与者,超重或肥胖的参与者发生复发性静脉血栓形成调整后的风险比分别为1.05(95% CI为0.88-1.27)和0.94(95%CI为0.74-1.19)。根据BMI百分位数等级进行分层也得到了类似的结果。在根据性别进行分层后,研究人员发现BMI和复发性静脉血栓形成之间也并存在相关性(虽然在超重参与者中可以观察到微弱的效应,但在肥胖的妇女中没有发现这种相关性),此外,根据第一次诱发或无诱因事件,以及深静脉血栓形成和肺栓塞进行分层,均未观察到这种相关性。

研究人员发现超重与复发性静脉血栓形成之间并不存在相关性。测量BMI并不是一个有用的工具,以确定复发性静脉血栓形成高风险的患者。

原始出处:

B. A. Vučković,,et al. Recurrent Venous Thrombosis Related to Overweight and Obesity: Results From The Mega Follow-Up Study. Journal of Thrombosis and Haemostasis.2017. http://onlinelibrary.wiley.com/doi/10.1111/jth.13710/full

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    2018-02-26 changfy
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    2018-04-16 fusion
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    2017-12-15 xue8602
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encodeId=0719204599a7, content=肥胖日益严重,是社会问题, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed May 31 04:53:10 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
    2017-06-20 天涯183

    非常好的文章,学习了,很受益

    0

  6. 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encodeId=0719204599a7, content=肥胖日益严重,是社会问题, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed May 31 04:53:10 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
    2017-06-14 天涯183

    非常好的文章,学习了,很受益

    0

  7. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99177, encryptionId=c82e991e71b, topicName=静脉血栓形成)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d387907505, createdName=ms5187542471278033, createdTime=Thu Jun 01 10:28:00 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204615, encodeId=ab2a2046155b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Wed May 31 05:37:42 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204599, encodeId=0719204599a7, content=肥胖日益严重,是社会问题, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed May 31 04:53:10 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
    2017-06-08 天涯183

    非常好的文章,学习了,很受益

    0

  8. 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  9. 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encodeId=0719204599a7, content=肥胖日益严重,是社会问题, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed May 31 04:53:10 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
    2017-05-31 lou.minghong

    学习

    0

  10. 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    2017-05-31 changjiu

    肥胖日益严重,是社会问题

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