J INTERN MED:CAIDE痴呆风险评分与老年痴呆症和脑血管病变有关!

2018-01-27 xing.T MedSci原创

由此可见,在年龄超过85岁的老年人群中,较高的CAIDE痴呆风险评分与脑梗塞的风险增加有关。

CAIDE痴呆风险评分是一般人群老年痴呆症风险的评估工具。但其与老年人痴呆症或血管神经病之间的相关性尚不明确。近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章,研究人员旨在探究基线CAIDE痴呆风险评分与85岁以上随访10年的老年人神经炎性斑块、神经原纤维缠结、脑梗塞、脑淀粉样血管病(CAA)之间的关系。

研究对象包括149名年龄超过85岁,研究之初没有痴呆症,并且有可用的临床及尸检资料。乌洛托品银染色用于检测β-淀粉样蛋白,改良的Bielschowsky法用于检测神经原纤维缠结和神经炎性斑块。从大脑半球、脑干和小脑切片中辨认出肉眼可见的梗塞灶。标准化的方法被用来确定微小梗死、CAA和α-突触核蛋白。基于评分时年龄、性别、体重指数、总胆固醇、收缩压、身体活动以及APOEε4携带状态(范围0-18点)来计算CAIDE风险评分。

研究人员发现CAIDE评分在11分以上与10年后更多的脑梗塞相关:比值比(95%可信区间)为2.10(1.06-4.16)。没有发现其与其它神经病理学之间存在相关性。

由此可见,在年龄超过85岁的老年人群中,较高的CAIDE痴呆风险评分与脑梗塞的风险增加有关。

原始出处:

Babak Hooshmand,et al. CAIDE dementia risk score, Alzheimer and cerebrovascular pathology: a population-based autopsy study.J INTERN MED. 2018. http://onlinelibrary.wiley.com/doi/10.1111/joim.12736/full

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    2018-09-17 Boyinsh
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GetPortalCommentsPageByObjectIdResponse(id=1608486, encodeId=85d8160848619, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jan 29 14:28:00 CST 2018, time=2018-01-29, status=1, ipAttribution=)]
    2018-05-26 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  5. 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    2018-03-20 wjywjy
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    2018-02-02 1e0f8808m18(暂无匿称)

    学习了.谢谢分享

    0

  8. 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    2018-01-31 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

  9. 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