Sci Rep:口腔接触砷可以引起听力障碍!

2017-08-10 AlexYang MedSci原创

到目前为止,在人类或者小鼠中还没有关于口腔接触砷(As)与听力障碍相关关系的研究信息。最近,有研究人员结合流行病学研究和实验研究,调查了在年龄为12到29岁的人和年轻小鼠中,口腔接触砷与听力障碍的关系。研究发现,在接触组(n=48)中,与对照组(n=29)的相比,受试者喝下含有砷的管井水,在4kHz(odds ratio (OR)=7.60; 95% confidence interval (CI

到目前为止,在人类或者小鼠中还没有关于口腔接触砷(As)与听力障碍相关关系的研究信息。最近,有研究人员结合流行病学研究和实验研究,调查了在年龄为12到29岁的人和年轻小鼠中,口腔接触砷与听力障碍的关系。

研究发现,在接触组(n=48)中,与对照组(n=29)的相比,受试者喝下含有砷的管井水,在4kHz(odds ratio (OR)=7.60; 95% confidence interval (CI): 1.56, 57.88)、8 kHz(OR=5.00; 95% CI: 1.48, 18.90)、12 kHz(OR=8.72; 95% CI: 2.09, 47.77)时表现出了显著更高的听力障碍风险。之后,研究人员在小鼠中进行了更高浓度砷实验,即小鼠饮下22.5mg/L的砷,该浓度要比人类受试者的浓度高的多。研究发现,接触组表现为听力障碍,并且在内耳表现出砷富集。另外,来自小鼠的柯蒂氏器官的体外接触砷可以显著的降低听力神经元和纤维的数目。最后,研究人员指出,该研究阐释了口腔接触砷在年轻人类和小鼠中可以引起听力障碍。

原始出处:

Xiang Li, Nobutaka Ohgami, Yasuhiro Omata et al. Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice. Sci Rep. 28 Jul 2017.

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    2017-08-12 ysjykql
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    2017-08-12 lishizhe
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    2017-08-10 135****7952平儿

    学了。。。。。。。。

    0

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    2017-08-10 135****7952平儿

    学了。。。。。。。。

    0

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    2017-08-10 qingfengqishi5

    学习了学习了

    0

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