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BMC Musculoskelet Disord：PPARγ抑制剂可有效预防类固醇相关的骨坏死

2018-05-18 MedSci MedSci原创

BADGEPPARγ类固醇骨坏死
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既往研究表明抑制PPARγ或是一种新的类固醇相关性骨坏死治疗方法。在这项研究中，我们研究了PPARγ抑制对兔模型中类固醇相关性骨坏死的预防作用。 将兔随机分为3组（正常组、模型组和BADGE组）。兔模型组和BADGE组诱导骨坏死。 BADGE组还接受双酚A二缩水甘油醚（BADGE），一种PPARγ拮抗剂，治疗6周。 组织病理学结果表明，使用BADGE处理的兔骨坏死改变，骨坏死和骨髓肥胖

既往研究表明抑制PPARγ或是一种新的类固醇相关性骨坏死治疗方法。在这项研究中，我们研究了PPARγ抑制对兔模型中类固醇相关性骨坏死的预防作用。

将兔随机分为3组（正常组、模型组和BADGE组）。兔模型组和BADGE组诱导骨坏死。 BADGE组还接受双酚A二缩水甘油醚（BADGE），一种PPARγ拮抗剂，治疗6周。

组织病理学结果表明，使用BADGE处理的兔骨坏死改变，骨坏死和骨髓肥胖的发生率明显降低。此外，BADGE处理的兔子表现出骨内压力降低和股骨血液灌注增加。微型计算机断层扫描和骨组织形态计量学表明，与模型组相比，BADGE组兔的骨质量和矿物质附着率明显改善。此外，BADGE组骨形成标志物骨钙蛋白的水平明显增加，骨吸收标志物TRACP的水平降低。总体而言，BADGE处理的兔表现出骨髓脂肪减少，伴随着骨形成的改善。

综上所述，这些观察结果表明，抑制PPARγ或是治疗类固醇相关性骨坏死的有效疗法。

原始出处：

Na Yuan, Jia Li, et al., BADGE, a synthetic antagonist for PPARγ, prevents steroid-related osteonecrosis in a rabbit model. BMC Musculoskelet Disord. 2018; 19: 129. doi:  10.1186/s12891-018-2050-6

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    2019-02-23 ms3025846204744509

    #BMC#

    0

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    2019-04-30 cmsvly

    #Disord#

    0

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    2018-06-15 zll0634

    #骨坏死#

    0

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    2019-04-27 cmj8wellington

    #Dis#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1974821, encodeId=096519e482176, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Feb 23 23:42:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784401, encodeId=19921e8440137, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Tue Apr 30 13:42:00 CST 2019, time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680003, encodeId=069916800033d, content=<a href='/topic/show?id=f0061016322a' target=_blank style='color:#2F92EE;'>#骨坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101632, encryptionId=f0061016322a, topicName=骨坏死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63ef27829166, createdName=zll0634, createdTime=Fri Jun 15 04:42:00 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012681, encodeId=6189201268139, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Apr 27 15:42:00 CST 2019, time=2019-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1851713, encodeId=c4301851e1352, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Nov 13 14:42:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313389, encodeId=e7ac131338938, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Sun May 20 09:42:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362880, encodeId=1d3e1362880ac, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun May 20 09:42:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316379, encodeId=45253163e969, content=既往研究表明抑制PPARγ或是一种新的类固醇相关性骨坏死治疗方法.在这项研究中.我们研究了PPARγ抑制对兔模型中类固醇相关性骨坏死的预防作用., beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri May 18 20:03:56 CST 2018, time=2018-05-18, status=1, ipAttribution=)]
    2018-11-13 jklm09

    #抑制剂#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1974821, encodeId=096519e482176, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Feb 23 23:42:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784401, encodeId=19921e8440137, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Tue Apr 30 13:42:00 CST 2019, time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680003, encodeId=069916800033d, content=<a href='/topic/show?id=f0061016322a' target=_blank style='color:#2F92EE;'>#骨坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101632, encryptionId=f0061016322a, topicName=骨坏死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63ef27829166, createdName=zll0634, createdTime=Fri Jun 15 04:42:00 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012681, encodeId=6189201268139, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Apr 27 15:42:00 CST 2019, time=2019-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1851713, encodeId=c4301851e1352, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Nov 13 14:42:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313389, encodeId=e7ac131338938, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Sun May 20 09:42:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362880, encodeId=1d3e1362880ac, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun May 20 09:42:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316379, encodeId=45253163e969, content=既往研究表明抑制PPARγ或是一种新的类固醇相关性骨坏死治疗方法.在这项研究中.我们研究了PPARγ抑制对兔模型中类固醇相关性骨坏死的预防作用., beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri May 18 20:03:56 CST 2018, time=2018-05-18, status=1, ipAttribution=)]
    2018-05-20 30397604

    #类固醇#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1974821, encodeId=096519e482176, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Sat Feb 23 23:42:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784401, encodeId=19921e8440137, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Tue Apr 30 13:42:00 CST 2019, time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680003, encodeId=069916800033d, content=<a href='/topic/show?id=f0061016322a' target=_blank style='color:#2F92EE;'>#骨坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101632, encryptionId=f0061016322a, topicName=骨坏死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63ef27829166, createdName=zll0634, createdTime=Fri Jun 15 04:42:00 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012681, encodeId=6189201268139, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Apr 27 15:42:00 CST 2019, time=2019-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1851713, encodeId=c4301851e1352, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Tue Nov 13 14:42:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313389, encodeId=e7ac131338938, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Sun May 20 09:42:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362880, encodeId=1d3e1362880ac, content=<a href='/topic/show?id=b723414321c' target=_blank style='color:#2F92EE;'>#坏死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41432, encryptionId=b723414321c, topicName=坏死)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Sun May 20 09:42:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316379, encodeId=45253163e969, content=既往研究表明抑制PPARγ或是一种新的类固醇相关性骨坏死治疗方法.在这项研究中.我们研究了PPARγ抑制对兔模型中类固醇相关性骨坏死的预防作用., beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri May 18 20:03:56 CST 2018, time=2018-05-18, status=1, ipAttribution=)]
    2018-05-20 millore

    #坏死#

    0

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    2018-05-18 有备才能无患

    既往研究表明抑制PPARγ或是一种新的类固醇相关性骨坏死治疗方法.在这项研究中.我们研究了PPARγ抑制对兔模型中类固醇相关性骨坏死的预防作用.

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