Ann Intensive Care:使用电阻抗成像对急性呼吸窘迫综合征患者的呼气末正压和潮气量进行个体化管理:一项初步的可行性研究

2021-06-28 “罂粟花”公众号 “罂粟花”公众号

背景

背景

急性呼吸窘迫综合征(ARDS)患者机械通气中,电阻抗成像(EIT)提供了肺泡循环和过度扩张的信息,以及床边的招募能力评估;利用EIT获得关于招募能力、肺过度膨胀和肺泡循环的信息,研发一种个体化呼气末正压(PEEP)和潮气量(VT)管理方案;本研究目的是评估基于EIT方案是否允许在不导致肺过度扩张情况下的个性化呼吸机设置,并评估其对呼吸系统顺应性、氧合及肺泡循环的影响。

方法

本研究纳入20例ARDS患者,最初根据ARDS管理指南,以VT6ml/kg潮气量进行机械通气,PEEP根据较低的PEEP/FiO2表调整;随后,基于EIT方案每30分钟调整一次呼吸机设置,持续时间为4小时。为了评估肺整体过度扩张,确定肺压力和张力是否分别保持在27mbar和2.0以下。

结果

用EIT进行机械通气的前瞻性优化所致更高的PEEP水平(16.5 [14-18]mbar优化前是10 [8-10]mbar;p = 0.0001);VT相似(5.7±0.92 ml/kg 优化前是5.8±0.47 ml/kg;p = 0.96)。所有患者整体肺应力均低于27 mbar, 20例患者中有19例的整体张力低于2.0;EIT优化后,依从性保持不变,氧合功能显着改善,肺泡循环减少。

结论

使用基于EIT方案调整PEEP和VT使得呼吸机设置个体化,改善氧合,减少肺泡循环,而不促进整体过度扩张。

原始出处:

Becher T, Buchholz V, Hassel D,et al. Individualization of PEEP and tidal volume in ARDS patients with electrical impedance tomography: a pilot feasibility study. Ann Intensive Care 2021 Jun 02;11(1)

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