JACC:评估后排除的胸痛患者高灵敏度肌钙蛋白T测定结果

2017-05-29 xiangting MedSci原创

当用hsTnT评估时,以不明原因胸痛被急诊直接排除的患者MACEs更少,风险状况更好。

大部分的胸痛患者在急诊被诊断为"不明原因的胸痛"后离开医院。而对这一群体测定高灵敏度肌钙蛋白T(hsTnT)是否会影响预后尚不清楚。

这项研究旨在调查对于被急诊排除的胸痛患者,引入hsTnT试验是否与降低心脏不良事件(MACEs)和心血管(CV)风险的发生相关。

研究共纳入了65,696例2006年至2013年间瑞典16家医院急诊排除的"不明原因胸痛"患者,引入hsTnT检测作为临床常规。根据国家注册管理机构的信息,比较常规和hsTnT检测,评估患者30天MACE和CV风险的发生。患者直接被排除和入院后再出院者分别进行分析。

与常规检测相比,用hsTnT进行评估时直接排除患者出现MACE比率更少(0.6%vs. 0.9%;优势比[OR]:0.7; 95%置信区间[CI]:0.57至0.83)。相比之下,在用hsTnT评估(7.2%vs. 3.4%; OR:2.18; 95%CI:1.76-2.72)时,入院后出院发生MACE的患者更多。入院患者在用hsTnT评估时具有更高的CV风险,而直接排除的患者具有较低的CV风险。

由此可见,当用hsTnT评估时,以不明原因胸痛被急诊直接排除的患者MACEs更少,风险状况更好。研究结果表明,更多的有真正风险患者的被识别确定和收住院。实施hsTnT测定已经改善了急诊的评估。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1853640, encodeId=4fa118536405f, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Wed Jun 28 13:49:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662226, encodeId=f55916622268a, content=<a href='/topic/show?id=6a426545472' target=_blank style='color:#2F92EE;'>#测定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65454, encryptionId=6a426545472, topicName=测定)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Oct 07 21:49:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775914, encodeId=8d071e759141e, content=<a href='/topic/show?id=ede06694367' target=_blank style='color:#2F92EE;'>#灵敏度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66943, encryptionId=ede06694367, topicName=灵敏度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd6838842412, createdName=respect, createdTime=Tue Aug 29 17:49:00 CST 2017, time=2017-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325379, encodeId=5dff13253e9ba, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed May 31 06:49:00 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569119, encodeId=6c2e1569119d1, content=<a href='/topic/show?id=2651810889c' target=_blank style='color:#2F92EE;'>#肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81088, encryptionId=2651810889c, topicName=肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f7f15492758, createdName=huangdf, createdTime=Wed May 31 06:49:00 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
    2017-06-28 hbwxf
  2. [GetPortalCommentsPageByObjectIdResponse(id=1853640, encodeId=4fa118536405f, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Wed Jun 28 13:49:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662226, encodeId=f55916622268a, content=<a href='/topic/show?id=6a426545472' target=_blank style='color:#2F92EE;'>#测定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65454, encryptionId=6a426545472, topicName=测定)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Oct 07 21:49:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775914, encodeId=8d071e759141e, content=<a href='/topic/show?id=ede06694367' target=_blank style='color:#2F92EE;'>#灵敏度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66943, encryptionId=ede06694367, topicName=灵敏度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd6838842412, createdName=respect, createdTime=Tue Aug 29 17:49:00 CST 2017, time=2017-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325379, encodeId=5dff13253e9ba, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed May 31 06:49:00 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569119, encodeId=6c2e1569119d1, content=<a href='/topic/show?id=2651810889c' target=_blank style='color:#2F92EE;'>#肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81088, encryptionId=2651810889c, topicName=肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f7f15492758, createdName=huangdf, createdTime=Wed May 31 06:49:00 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1853640, encodeId=4fa118536405f, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Wed Jun 28 13:49:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662226, encodeId=f55916622268a, content=<a href='/topic/show?id=6a426545472' target=_blank style='color:#2F92EE;'>#测定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65454, encryptionId=6a426545472, topicName=测定)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Oct 07 21:49:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775914, encodeId=8d071e759141e, content=<a href='/topic/show?id=ede06694367' target=_blank style='color:#2F92EE;'>#灵敏度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66943, encryptionId=ede06694367, topicName=灵敏度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd6838842412, createdName=respect, createdTime=Tue Aug 29 17:49:00 CST 2017, time=2017-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325379, encodeId=5dff13253e9ba, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed May 31 06:49:00 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569119, encodeId=6c2e1569119d1, content=<a href='/topic/show?id=2651810889c' target=_blank style='color:#2F92EE;'>#肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81088, encryptionId=2651810889c, topicName=肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f7f15492758, createdName=huangdf, createdTime=Wed May 31 06:49:00 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
    2017-08-29 respect
  4. [GetPortalCommentsPageByObjectIdResponse(id=1853640, encodeId=4fa118536405f, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Wed Jun 28 13:49:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662226, encodeId=f55916622268a, content=<a href='/topic/show?id=6a426545472' target=_blank style='color:#2F92EE;'>#测定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65454, encryptionId=6a426545472, topicName=测定)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Oct 07 21:49:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775914, encodeId=8d071e759141e, content=<a href='/topic/show?id=ede06694367' target=_blank style='color:#2F92EE;'>#灵敏度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66943, encryptionId=ede06694367, topicName=灵敏度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd6838842412, createdName=respect, createdTime=Tue Aug 29 17:49:00 CST 2017, time=2017-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325379, encodeId=5dff13253e9ba, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed May 31 06:49:00 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569119, encodeId=6c2e1569119d1, content=<a href='/topic/show?id=2651810889c' target=_blank style='color:#2F92EE;'>#肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81088, encryptionId=2651810889c, topicName=肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f7f15492758, createdName=huangdf, createdTime=Wed May 31 06:49:00 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1853640, encodeId=4fa118536405f, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Wed Jun 28 13:49:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662226, encodeId=f55916622268a, content=<a href='/topic/show?id=6a426545472' target=_blank style='color:#2F92EE;'>#测定#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65454, encryptionId=6a426545472, topicName=测定)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Oct 07 21:49:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775914, encodeId=8d071e759141e, content=<a href='/topic/show?id=ede06694367' target=_blank style='color:#2F92EE;'>#灵敏度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66943, encryptionId=ede06694367, topicName=灵敏度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd6838842412, createdName=respect, createdTime=Tue Aug 29 17:49:00 CST 2017, time=2017-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325379, encodeId=5dff13253e9ba, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Wed May 31 06:49:00 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569119, encodeId=6c2e1569119d1, content=<a href='/topic/show?id=2651810889c' target=_blank style='color:#2F92EE;'>#肌钙蛋白T#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81088, encryptionId=2651810889c, topicName=肌钙蛋白T)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f7f15492758, createdName=huangdf, createdTime=Wed May 31 06:49:00 CST 2017, time=2017-05-31, status=1, ipAttribution=)]

相关资讯

张铭:胸痛不等于心痛,如何问诊?

近日,对PROMISE研究中近万例稳定胸痛患者为期2年的随访结果表明,采用一种新的评估工具可准确甄别此类最低危人群,节省医疗成本,也免去患者不必要的担心,结果发表于《JAMA Cardiology》。针对这一研究结果,首都医科大学附属北京安贞医院张铭教授受"心在线"之邀,发表了看法,特别强调了这一结果对临床医生的启示。

Ann Intern Med:使用HEART 评分是否对胸痛患者有益?

HEART(历史,心电图,年龄,危险因素和初始肌钙蛋白)评分是一种易于应用的手段,根据其主要不良心脏事件(MACE)的短期风险对胸痛患者进行分层,但其效果在日常应用中是未知数。该项目的主要目的是衡量HEART评分对患者结局和医疗资源使用情况的影响。

心脏X综合症:找不出原因的胸痛

X心脏综合症的特点是:反复发作胸闷胸痛,冠状动脉造影或冠脉CT正常,运动平板试验阳性。

胸痛但冠脉造影正常,应警惕这五种微循环功能异常

许多胸痛患者行冠状动脉造影时并不显示心外膜冠脉阻塞病变,这可能与冠状动脉微循环功能障碍相关。那么如何改善冠状动脉微循环功能障碍?

无痛性心梗:沉默却常见,不是所有的心梗都会胸痛

在日常临床工作中,时不时会碰到心电图提示陈旧性心肌梗死的患者,无论怎么仔细询问病史,既往都没有明确的胸闷、胸痛等心梗相关表现。这类患者有时看起来「奇怪」,难道都心梗了自己还不知道?其实,这类心肌梗死并不奇怪,而且比想象中常见得多。它有专门的名字,无痛性心肌梗死或无症状性心肌梗死(Silent Myocardial Infarction,SMI),因心梗时症状轻或不典型而未被察觉。SMI 是缺血

别误会!这7种胸痛不是心脏病

胸痛很容易使人联想到心脏病。美国《健康》杂志采访多位资深心脏病专家后指出,有7种情况引发的胸痛虽非心脏病所致,但也要谨慎处理。