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PNAS：血液基因表达分析可区别病毒和细菌导致的发烧

2013-09-27 MedSci原创 MedSci原创

发烧病毒细菌基因表达
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在无其他疾病的症状下，如何判断孩子发烧是由病毒还是细菌引发的？发热是病毒和细菌感染的一个常见症状，但是发热源常常在临床检查中不那么显而易见。现在，华盛顿大学医学院的科学家们发现，血液中的基因表达特征可以帮助区别幼儿的发热是由病毒还是由细菌造成的。【原文下载】在这项研究中，科学家们研究了发热儿童的血液是否表现出了病毒和细菌的特定基因表达特征，这些特征可能在区别这两种发热源方面有用。研究人员分析了来自


在无其他疾病的症状下，如何判断孩子发烧是由病毒还是细菌引发的？发热是病毒和细菌感染的一个常见症状，但是发热源常常在临床检查中不那么显而易见。

现在，华盛顿大学医学院的科学家们发现，血液中的基因表达特征可以帮助区别幼儿的发热是由病毒还是由细菌造成的。【原文下载】

在这项研究中，科学家们研究了发热儿童的血液是否表现出了病毒和细菌的特定基因表达特征，这些特征可能在区别这两种发热源方面有用。研究人员分析了来自各种病毒或细菌感染阳性的 30 名发热儿童以及 35 名没有发热但是其中一些人呈病毒感染阳性的儿童的基因表达数据。

研究人员发现不发热的病毒阳性和病毒阴性的儿童的特征谱是相互难以区分的，并且有别于发热儿童的特征谱。此外，这项分析揭示出了发热儿童的特定病毒感染——诸如疱疹病毒、腺病毒或肠道病毒——以及急性细菌感染的独特特征；这些特征比区分细菌和病毒感染的传统的白细胞计数更准确。

这些发现表明，血液基因表达分析可能会成为理解儿童发热来源的一种有用的工具。

原文下载

Xinran Hu, Jinsheng Yu, Seth D. Crosby, and Gregory A. Storch. Gene expression profiles in febrile children with defined viral and bacterial infection. PNAS, July 15, 2013 DOI: 10.1073/pnas.1302968110

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1855443, encodeId=b7da185544366, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Mon Mar 31 13:01:00 CST 2014, time=2014-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7250, encodeId=1ec1e2502d, content=太好了，临床中一直特别需要在抗感染时好确定抗感染药物，如何将该项研究成果快速转化经行临床应用呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c8c95163, createdName=rosewenly, createdTime=Sun Feb 09 11:12:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936618, encodeId=0903193661868, content=<a href='/topic/show?id=20f5902e082' target=_blank style='color:#2F92EE;'>#表达分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90270, encryptionId=20f5902e082, topicName=表达分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Wed Nov 20 13:01:00 CST 2013, time=2013-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347993, encodeId=196d134e99390, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Sun Sep 29 06:01:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376866, encodeId=8fcb13e68666e, content=<a href='/topic/show?id=ddc13e87938' target=_blank style='color:#2F92EE;'>#发烧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37879, encryptionId=ddc13e87938, topicName=发烧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25c8396, createdName=ssnine, createdTime=Sun Sep 29 06:01:00 CST 2013, time=2013-09-29, status=1, ipAttribution=)]
    2014-03-31 drwjr

    #PNAS#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1855443, encodeId=b7da185544366, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Mon Mar 31 13:01:00 CST 2014, time=2014-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7250, encodeId=1ec1e2502d, content=太好了，临床中一直特别需要在抗感染时好确定抗感染药物，如何将该项研究成果快速转化经行临床应用呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c8c95163, createdName=rosewenly, createdTime=Sun Feb 09 11:12:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936618, encodeId=0903193661868, content=<a href='/topic/show?id=20f5902e082' target=_blank style='color:#2F92EE;'>#表达分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90270, encryptionId=20f5902e082, topicName=表达分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Wed Nov 20 13:01:00 CST 2013, time=2013-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347993, encodeId=196d134e99390, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Sun Sep 29 06:01:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376866, encodeId=8fcb13e68666e, content=<a href='/topic/show?id=ddc13e87938' target=_blank style='color:#2F92EE;'>#发烧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37879, encryptionId=ddc13e87938, topicName=发烧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25c8396, createdName=ssnine, createdTime=Sun Sep 29 06:01:00 CST 2013, time=2013-09-29, status=1, ipAttribution=)]
    2014-02-09 rosewenly

    太好了，临床中一直特别需要在抗感染时好确定抗感染药物，如何将该项研究成果快速转化经行临床应用呢？

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1855443, encodeId=b7da185544366, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Mon Mar 31 13:01:00 CST 2014, time=2014-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7250, encodeId=1ec1e2502d, content=太好了，临床中一直特别需要在抗感染时好确定抗感染药物，如何将该项研究成果快速转化经行临床应用呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c8c95163, createdName=rosewenly, createdTime=Sun Feb 09 11:12:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936618, encodeId=0903193661868, content=<a href='/topic/show?id=20f5902e082' target=_blank style='color:#2F92EE;'>#表达分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90270, encryptionId=20f5902e082, topicName=表达分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Wed Nov 20 13:01:00 CST 2013, time=2013-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347993, encodeId=196d134e99390, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Sun Sep 29 06:01:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376866, encodeId=8fcb13e68666e, content=<a href='/topic/show?id=ddc13e87938' target=_blank style='color:#2F92EE;'>#发烧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37879, encryptionId=ddc13e87938, topicName=发烧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25c8396, createdName=ssnine, createdTime=Sun Sep 29 06:01:00 CST 2013, time=2013-09-29, status=1, ipAttribution=)]
    2013-11-20 12498bd5m16暂无昵称

    #表达分析#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1855443, encodeId=b7da185544366, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Mon Mar 31 13:01:00 CST 2014, time=2014-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7250, encodeId=1ec1e2502d, content=太好了，临床中一直特别需要在抗感染时好确定抗感染药物，如何将该项研究成果快速转化经行临床应用呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c8c95163, createdName=rosewenly, createdTime=Sun Feb 09 11:12:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936618, encodeId=0903193661868, content=<a href='/topic/show?id=20f5902e082' target=_blank style='color:#2F92EE;'>#表达分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90270, encryptionId=20f5902e082, topicName=表达分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Wed Nov 20 13:01:00 CST 2013, time=2013-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347993, encodeId=196d134e99390, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Sun Sep 29 06:01:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376866, encodeId=8fcb13e68666e, content=<a href='/topic/show?id=ddc13e87938' target=_blank style='color:#2F92EE;'>#发烧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37879, encryptionId=ddc13e87938, topicName=发烧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25c8396, createdName=ssnine, createdTime=Sun Sep 29 06:01:00 CST 2013, time=2013-09-29, status=1, ipAttribution=)]
    2013-09-29 bioon1

    #基因表达#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1855443, encodeId=b7da185544366, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Mon Mar 31 13:01:00 CST 2014, time=2014-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7250, encodeId=1ec1e2502d, content=太好了，临床中一直特别需要在抗感染时好确定抗感染药物，如何将该项研究成果快速转化经行临床应用呢？, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c8c95163, createdName=rosewenly, createdTime=Sun Feb 09 11:12:00 CST 2014, time=2014-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936618, encodeId=0903193661868, content=<a href='/topic/show?id=20f5902e082' target=_blank style='color:#2F92EE;'>#表达分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90270, encryptionId=20f5902e082, topicName=表达分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Wed Nov 20 13:01:00 CST 2013, time=2013-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347993, encodeId=196d134e99390, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Sun Sep 29 06:01:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376866, encodeId=8fcb13e68666e, content=<a href='/topic/show?id=ddc13e87938' target=_blank style='color:#2F92EE;'>#发烧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37879, encryptionId=ddc13e87938, topicName=发烧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25c8396, createdName=ssnine, createdTime=Sun Sep 29 06:01:00 CST 2013, time=2013-09-29, status=1, ipAttribution=)]
    2013-09-29 ssnine

    #发烧#

    0