J Cosmet Dermatol:发酵石榴提取物可有效防止皮肤氧化和老化

2022-06-15 MedSci原创 MedSci原创

每天食用发酵石榴提取物可以保护皮肤免受氧化应激,减缓皮肤老化,从而发挥抗氧化和美白的功能。

衰老是一个从出生到死亡的连续过程,抗衰老已成为现代医学研究的一个重要目标。许多因素会加剧皮肤的老化,包括暴露于紫外线、营养不良、身体疾病、自由基和活性氧(ROS),这些都会导致与年龄相关的胶原蛋白流失和皮肤皱纹的形成。石榴可能会改善皮肤炎症和疼痛,包括带状疱疹基质性角膜炎。发酵是一种生物技术,可以通过产生抗氧化剂自然地诱发健康益处。然而,发酵石榴提取物(FPE)对皮肤的抗衰老作用仍不清楚。近日,发表于J Cosmet Dermatol的一项研究评估了发酵石榴作为功能性补充剂(FPE饮料,FPE-D)和化妆品成分(FPE血清,FPE-S)在体外和体内的效果。

 

为研究FPE产品对抗氧化、抗酪氨酸酶、抗炎和抗衰老的作用。研究人员在这项双盲研究中纳入了40名受试者,随机分配到FPE-D或安慰剂饮料组(每个受试者每天喝50毫升FPE-D /安慰剂饮料,持续8周),另外40名受试者被招募到FPE-S或安慰剂组(每个受试者每天和晚上/每天喝约3毫升FPE-S /安慰剂饮料,持续4周)。

在研究FPE产品对DPPH、ABTS+和NO-自由基清除活性的影响,以及它们对酪氨酸酶活性的抑制作用和对健康受试者皮肤健康的改善方面。研究人员发现,相较于基线时期,FPE-D在8周时改善了大多数受试者皮肤的水分、亮度、弹性和胶原蛋白密度(P < 0.05)。服用FPE-S 4周后,皮肤的水分、亮度、弹性、斑点、紫外线斑点和胶原蛋白密度都比基线时期略好(P < 0.05)。

综上所述,该研究结果表明,每天食用发酵石榴提取物可以保护皮肤免受氧化应激,减缓皮肤老化,从而发挥抗氧化和美白的功能。

原始出处:

Leong-Perng Chan, et al., Fermented pomegranate extracts protect against oxidative stress and aging of skin.  J Cosmet Dermatol. 2022 May;21(5):2236-2245. doi: 10.1111/jocd.14379.  

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    2022-10-25 tcm99hq
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    2022-08-27 一闲
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