Hypertension:高盐敏感性是主要特点,清晨理想收缩压<125 mmHg

2018-01-16 佚名 中国循环杂志

近期,Hypertension杂志刊出了《改善亚洲高血压患者管理的共识文件》。上海交通大学医学院附属瑞金医院王继光教授参与了本共识的制定。


近期,Hypertension杂志刊出了《改善亚洲高血压患者管理共识文件》。上海交通大学医学院附属瑞金医院王继光教授参与了本共识的制定。
 
共识指出,管理亚洲高血压患者要兼顾亚洲人群高血压和心血管疾病的特点。
 
亚洲高血压和心血管疾病特点体现在三点:
 
(1)卒中(特别是出血性卒中)和非缺血性心力衰竭是高血压相关心血管疾病的常见结局。
 
(2)亚洲人群血压和心血管疾病之间的关联比西方人群更强。
 
(3)高盐敏感性是亚洲高血压的特点,亚洲人比西方人有更高的盐敏感性和盐摄入量。
 
共识声明指出,在东亚国家,卒中是主要的死亡原因,疾病负担较重,这可能与高钠摄入有关。
 
减少钠摄入可以有效降低血压,每减少2.3 g/d可使收缩压下降3.82 mmHg。钙拮抗剂可以被认为是卒中后高血压控制的有用方法。
 
共识还指出,在亚洲国家,血管老化可能会成为高血压的主要表型。亚洲人群动脉血管的解剖学特点可能与血管老化现象存在相关性,但以此为靶点的降压策略还有待研究。
 
共识推荐诊室外血压以排除白大衣高血压,因为与其他地区相比,在亚洲存在更多的假性高血压和假性未控制的高血压。
 
此外,鉴于清晨高血压可能对心血管事件的发生存在重要影响,共识建议对于亚洲人群,起始应关注清晨血压,然后是夜间血压。
 
共识声明建议老年高血压患者的血压控制目标为<140/90 mmHg。推荐对老年高血压患者分阶段实现血压达标。
 
对于高血压合并2型糖尿病患者,降压目标为<130/80 mmHg。
 
在高血压合并房颤并接受抗凝治疗的患者,可考虑收缩压目标为<130 mmHg以降低出血性卒中风险,这对于亚洲患者更为重要,因为该人群更容易发生抗凝治疗相关的卒中和出血并发症。
 
共识声明指出,24小时严格血压控制很重要,特别是对于亚洲患者。因为亚洲患者控制好血压的获益可能比西方患者更大。
 
而控制清晨高血压是24小时血压控制的第一步。收缩压125 mmHg可能是理想的清晨血压目标。
 
考虑到亚洲高血压患者的特点,使用长效钙拮抗剂和RAS抑制剂更好。β受体阻滞剂可用于特殊人群,例如心率增快的年轻高血压患者或冠心病、房颤心衰患者。
 
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    2018-07-27 feather89
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  5. 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  8. 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2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-16 139****0239

    henhao

    0

  9. 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    2018-01-16 doctorJiangchao

    继续学习.

    0

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