Chest:肺动脉高压患者出现心包积液预示其死亡风险显著增加

2013-10-08 sd3212 丁香园

肺动脉高压(PAH)患者心包积液的发生状况及其对患者预后的影响目前仍不清楚。为了加深对这一问题的认识,来自美国明尼苏达州罗切斯特市梅奥诊所心内科的Garvan C. Kane博士及其同事进行了一项研究,研究结果在线发表于2013年8月15日的《CHEST》杂志上。 【原文阅读】 研究结果显示:心包积液在PAH患者中较常见,尽管其很少具有血流动力学意义,但即使是轻度的心包积液也与患者死亡率的显著增

肺动脉高压(PAH)患者心包积液的发生状况及其对患者预后的影响目前仍不清楚。为了加深对这一问题的认识,来自美国明尼苏达州罗切斯特市梅奥诊所心内科的Garvan C. Kane博士及其同事进行了一项研究,研究结果在线发表于2013年8月15日的《CHEST》杂志上。 【原文阅读】

研究结果显示:心包积液在PAH患者中较常见,尽管其很少具有血流动力学意义,但即使是轻度的心包积液也与患者死亡率的显著增加相关。此外,心包积液可能还是患者存在相关胶原血管病和右心房高压的反映。

该研究是一项单中心的队列研究,其研究对象主要为577例患有1类PAH的受试者。这些患者均于1995年1月1日至2005年12月31日期间在梅奥诊所就诊,并进行了经胸超声心动图检查、和≥5年的随访;其中部分患者还根据病情需要,进行了超声引导下的心包穿刺。

该研究的主要结果为:共有150例(26%)患者存在超声心动图提示下的心包积液;其中,128例为少量积液,22例为中等量积液。大多数(82%)中等或中等量以上的积液,均发生于患有结缔组织病的PAH患者。心包无积液、有少量积液、以及有≥中等量积液的受试者,其平均右心房压力分别为13.4±4.4、15.1±4.4、和17.0±4毫米汞柱。而上述3组患者的中位数生存时间则分别为76.5、42.3、和11.3个月。在22例出现中度或中度以上心包积液的患者中,有4例由于存在临床和超声方面的血流动力学影响,最终进行了超声引导下的心包穿刺放液。当患者接受放液时,其积液量多较大(858±469毫升),且常为浆液性。所有心包穿刺放液均在超声引导下,由经验丰富、且穿刺并发症和死亡率均较低的心脏病超声专家谨慎地进行。

该研究结果显示:心包积液在PAH患者中较常见,尽管其很少具有血流动力学意义,但即使是轻度的心包积液也与患者死亡率的显著增加相关。此外,心包积液的出现可能还是患者存在相关胶原血管病和右心房高压的反映。
该研究结果显示:心包积液在PAH患者中较常见,尽管其很少具有血流动力学意义,但即使是轻度的心包积液也与患者死亡率的显著增加相关。

原文阅读

Fenstad ER, Le RJ, Sinak LJ, Maradit-Kremers H, Ammash NM, Ayalew AM, Villarraga HR, Oh JK, Frantz RP, McCully RB, McGoon MD, Kane GC.Pericardial Effusions in Pulmonary Arterial Hypertension: Characteristics, Prognosis and Role of Drainage.Chest. 2013 Aug 15.

 

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    2014-05-07 Smile2680
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