浙江大学医学院附属妇产科医院程晓东教授谈宫颈癌预防更佳措施:疫苗和筛查,一个都别少

2020-11-08 网络 网络

“谈到宫颈癌这个话题,未免有些沉重,近年来宫颈癌发病逐年上升,而且呈现出年轻化的态势,需要引起我们的重视。但是也不要谈癌色变,因为宫颈癌这个疾病是可以通过综合手段有效预防的,接种HPV疫苗

“谈到宫颈癌这个话题,未免有些沉重,近年来宫颈癌发病逐年上升,而且呈现出年轻化的态势,需要引起我们的重视。但是也不要谈癌色变,因为宫颈癌这个疾病是可以通过综合手段有效预防的,接种HPV疫苗和定期宫颈癌筛查就是预防宫颈癌的最佳措施。如果能在HPV感染高峰期前及早接种疫苗,就可以很大程度的减少HPV感染及宫颈癌发生的风险。”11月8日,浙江大学医学院附属妇产科医院副院长程晓东教授在第三届中国国际进口博览会上说道。

9~14岁是HPV疫苗的黄金年龄

目前已证实,高危型人乳头瘤病毒(high-risk human papillomavirus,HR-HPV)持续感染,尤其HPV16、18型持续感染是宫颈癌最主要的致病因素。由于宫颈癌疾病预后差、疾病负担重,通过综合手段预防宫颈癌得到广泛的认可,而接种预防性HPV疫苗作为宫颈癌一级预防的重要手段受到全球权威卫生机构或组织的推荐。

程晓东教授表示:“HPV主要通过性接触传播,因此,在开始性行为之前接种HPV疫苗的效果是最好的。WHO也指出,9~14岁是HPV疫苗的最佳接种年龄。从疫苗的研发原理来看,HPV疫苗接种不会导致感染,同时也通过大量的接种实践证明,HPV疫苗是安全的。”

正确看待HPV疫苗,做明智的选择

如何选择适合自己的HPV疫苗?程晓东教授指出,疫苗的选择应基于疫苗的保护效果,选择适合自己的疫苗。

世界卫生组织2017年指出:现有证据表明,从公共卫生角度,二价、四价和九价疫苗在免疫原性以及预防16、18型HPV相关宫颈癌的效力和效果方面无差别,三种疫苗都可预防大多数的相关癌症。

很多人认为价数越高,防癌系数越高,程晓东教授进一步解释,“但实际上目前我国已批准上市的四种HPV疫苗,无论在免疫原性,还是预防16型、18型HPV相关宫颈癌的效力和效果方面均无差别,都可预防大多数的宫颈癌;对于45周岁以下成年女性,选择可以获取的任意一种HPV疫苗及时接种,对于宫颈癌的保护效果都是很好的,年龄越小,越早获得保护,所以建议9-14岁女孩应该优先接种。此外,疫苗的成分和保护效力密切相关,疫苗的主要成分包括抗原和佐剂,而创新佐剂系统能够提高免疫反应的效果,达到最终的对疾病保护的目的。”

接种HPV后并不能一劳永逸

随着HPV疫苗的问世,WHO推出了一系列宫颈癌防控策略,使宫颈癌的综合防控策略逐渐从对适龄妇女定期筛查的二级预防,提前至对女性进行HPV疫苗接种的一级预防。

2018年世界卫生组织进一步明确,计划到2030年90%的女孩在15岁前均接种HPV疫苗,70%的女性在35和45岁时各接受一次高精度的筛查,90%被确诊患有宫颈疾病的女性接受治疗和护理,降低30%宫颈癌死亡率 。

程晓东教授提醒道:“接种宫颈癌疫苗并不能一劳永逸,鉴于我国目前子宫颈癌发病年龄特点,推荐筛查起始年龄在25-30岁。65岁及以上女性若过去10年内每3年一次连续3次细胞学检查无异常或每5年一次连续2次HPV检测阴性,则不需要继续筛查。”

 

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    0

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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Tue Nov 10 13:36:50 CST 2020, time=2020-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898193, encodeId=599b89819320, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e7d62153496, createdName=182201837cm, createdTime=Tue Nov 10 09:54:07 CST 2020, time=2020-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898044, encodeId=d68989804495, content=打疫苗, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2b82397018, createdName=12346c4dm64暂无昵称, createdTime=Mon Nov 09 19:49:12 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897864, encodeId=ad7f89e864bb, content=疫苗啥时候能免费, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200930/e0fbd563d9054278997cb567f3351d90/db37f938d1ea4a96a7e324c062c9461b.jpg, createdBy=3d615392683, createdName=我是梁, createdTime=Mon Nov 09 08:07:50 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897844, encodeId=519989e844c3, content=无性生活前注射任何一种疫苗,都可以降低宫颈癌患病概率?, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9665433008, createdName=ms2000001443379879, createdTime=Sun Nov 08 23:16:53 CST 2020, time=2020-11-08, status=1, ipAttribution=)]
    2020-11-10 Wlgank

    疫苗➕筛查

    0

  5. 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createdBy=c9665433008, createdName=ms2000001443379879, createdTime=Sun Nov 08 23:16:53 CST 2020, time=2020-11-08, status=1, ipAttribution=)]
  6. 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authenticateStatus=null, createdAvatar=, createdBy=b2b82397018, createdName=12346c4dm64暂无昵称, createdTime=Mon Nov 09 19:49:12 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897864, encodeId=ad7f89e864bb, content=疫苗啥时候能免费, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200930/e0fbd563d9054278997cb567f3351d90/db37f938d1ea4a96a7e324c062c9461b.jpg, createdBy=3d615392683, createdName=我是梁, createdTime=Mon Nov 09 08:07:50 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897844, encodeId=519989e844c3, content=无性生活前注射任何一种疫苗,都可以降低宫颈癌患病概率?, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9665433008, createdName=ms2000001443379879, createdTime=Sun Nov 08 23:16:53 CST 2020, time=2020-11-08, status=1, ipAttribution=)]
    2020-11-10 一闲
  7. 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createdBy=c9665433008, createdName=ms2000001443379879, createdTime=Sun Nov 08 23:16:53 CST 2020, time=2020-11-08, status=1, ipAttribution=)]
    2020-11-10 182201837cm

    学习了

    0

  8. 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createdName=一闲, createdTime=Fri Dec 11 13:36:50 CST 2020, time=2020-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906589, encodeId=cc3d906589f1, content=66, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200615/2632ad9b0cbe41099afc78cc410e4829/a6c809eee225447c99a44260c2c470ae.jpg, createdBy=27dc5388613, createdName=ms4000000194031466, createdTime=Thu Dec 10 09:05:37 CST 2020, time=2020-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898254, encodeId=fd49898254fd, content=疫苗➕筛查, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Tue Nov 10 13:36:50 CST 2020, time=2020-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898193, encodeId=599b89819320, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e7d62153496, createdName=182201837cm, createdTime=Tue Nov 10 09:54:07 CST 2020, time=2020-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898044, encodeId=d68989804495, content=打疫苗, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2b82397018, createdName=12346c4dm64暂无昵称, createdTime=Mon Nov 09 19:49:12 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897864, encodeId=ad7f89e864bb, content=疫苗啥时候能免费, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200930/e0fbd563d9054278997cb567f3351d90/db37f938d1ea4a96a7e324c062c9461b.jpg, createdBy=3d615392683, createdName=我是梁, createdTime=Mon Nov 09 08:07:50 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897844, encodeId=519989e844c3, content=无性生活前注射任何一种疫苗,都可以降低宫颈癌患病概率?, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9665433008, createdName=ms2000001443379879, createdTime=Sun Nov 08 23:16:53 CST 2020, time=2020-11-08, status=1, ipAttribution=)]
    2020-11-09 12346c4dm64暂无昵称

    打疫苗

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1859877, encodeId=478018598e7f4, content=<a href='/topic/show?id=f0a6342e2b0' target=_blank style='color:#2F92EE;'>#医学院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=34272, encryptionId=f0a6342e2b0, topicName=医学院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Thu Sep 23 22:36:50 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745693, encodeId=dfb41e456930c, content=<a href='/topic/show?id=73826552320' target=_blank style='color:#2F92EE;'>#浙江大学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65523, encryptionId=73826552320, topicName=浙江大学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c35635545425, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Tue Nov 10 13:36:50 CST 2020, time=2020-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898193, encodeId=599b89819320, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e7d62153496, createdName=182201837cm, createdTime=Tue Nov 10 09:54:07 CST 2020, time=2020-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=898044, encodeId=d68989804495, content=打疫苗, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b2b82397018, createdName=12346c4dm64暂无昵称, createdTime=Mon Nov 09 19:49:12 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897864, encodeId=ad7f89e864bb, content=疫苗啥时候能免费, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200930/e0fbd563d9054278997cb567f3351d90/db37f938d1ea4a96a7e324c062c9461b.jpg, createdBy=3d615392683, createdName=我是梁, createdTime=Mon Nov 09 08:07:50 CST 2020, time=2020-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=897844, encodeId=519989e844c3, content=无性生活前注射任何一种疫苗,都可以降低宫颈癌患病概率?, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9665433008, createdName=ms2000001443379879, createdTime=Sun Nov 08 23:16:53 CST 2020, time=2020-11-08, status=1, ipAttribution=)]
    2020-11-09 我是梁

    疫苗啥时候能免费

    0

  10. 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createdBy=c9665433008, createdName=ms2000001443379879, createdTime=Sun Nov 08 23:16:53 CST 2020, time=2020-11-08, status=1, ipAttribution=)]
    2020-11-08 ms2000001443379879

    无性生活前注射任何一种疫苗,都可以降低宫颈癌患病概率?

    0