Comput Methods Programs Biomed:苏州医工所在量化评定脑卒中患者肢体运动功能研究中取得进展

2017-05-28 佚名 苏州生物医学工程技术研究所

随着我国老龄化社会的加剧,脑卒中已经成为目前世界上三大致死和致残疾病之一。然而,受我国康复资源紧张、分布不均衡等因素的限制,许多脑卒中患者无法得到完善的康复治疗和指导服务。同时,传统的临床康复评定主要依赖评定量表(如:Brunnstrom六阶段分期法、Fugl-Meyer评定量表和Wolf运动功能测试等),容易受康复医生的主观因素影响且存在“天花板”效应,无法精细、准确地反映脑卒中患者的肢体运动功

随着我国老龄化社会的加剧,脑卒中已经成为目前世界上三大致死和致残疾病之一。然而,受我国康复资源紧张、分布不均衡等因素的限制,许多脑卒中患者无法得到完善的康复治疗和指导服务。同时,传统的临床康复评定主要依赖评定量表(如:Brunnstrom六阶段分期法、Fugl-Meyer评定量表和Wolf运动功能测试等),容易受康复医生的主观因素影响且存在“天花板”效应,无法精细、准确地反映脑卒中患者的肢体运动功能。

基于以上问题,中国科学院苏州生物医学工程技术研究所光健康研究中心郭立泉、郁磊等人使用自己开发的远程康复训练与评定系统,以脑卒中患者为研究对象,使用多传感器融合的方法对患者肢体运动功能进行了量化评定。首先利用极限学习机(Extreme Learning Machine, ELM)算法建立7个动作各自的多源传感器信号与Fugl-Meyer量表动作对应得分之间的非线性映射模型;然后再建立综合量化康复评定模型实现7个动作各自得分与Fugl-Meyer量表上肢部分总得分之间的映射模型。在模型学习阶段,共有200组多源传感器数据参与训练;在模型测试阶段,共包含40组多源传感器数据作为测试。实验结果表明,所建立的映射模型具有良好的泛化性能,可以准确地从多传感器信息中预测出脑卒中患者的Fugl-Meyer得分,且二者相关性的决定系数可达0.918。

同时,为了降低映射模型的复杂度,基于集成学习思想和遗传算法对多传感器信息中的高维特征进行降维和筛选,用Jaccard系数作为鲁棒性度量指标。研究结果表明,与传统的特征选择算法相比,本方法具备更好的稳定性,平均Jaccard系数达到了0.926。相关研究成果发表在Computer Methods & Programs in Biomedicine 杂志上。

原始出处:

Yu L, Xiong D, Guo L,et al.A remote quantitative Fugl-Meyer assessment framework for stroke patients based on wearable sensor networks.Comput Methods Programs Biomed. 2016 May

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    2018-04-13 liuquan
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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607582, encodeId=f8c0160e582d1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue May 30 07:46:00 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-11-03 一闲
  4. 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607582, encodeId=f8c0160e582d1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue May 30 07:46:00 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
  5. 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607582, encodeId=f8c0160e582d1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue May 30 07:46:00 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-09-26 sunylz
  6. 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  7. 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  8. 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607582, encodeId=f8c0160e582d1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue May 30 07:46:00 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-30 虈亣靌

    涨知识了,谢谢分享!

    0

  9. 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time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607582, encodeId=f8c0160e582d1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue May 30 07:46:00 CST 2017, time=2017-05-30, status=1, ipAttribution=)]
    2017-05-30 sunylz
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复旦大学医学神经生物学国家重点实验室、脑科学研究院赵冰樵教授研究团队发现,一种被称为 “重组ADAMTS13”的药物可以促进脑卒中后血管新生和功能重塑,从而有效改善脑卒中引起的神经功能障碍。近日,相关研究成果在线发表于《血液》杂志。赵冰樵团队采用活体小鼠脑血管多光子显微镜实时动态成像等先进技术,发现敲除ADAMTS13基因后,小鼠在脑卒中恢复期时血脑屏障的破坏更加严重,血管内大分子物质的血管外渗漏

Stroke:脑卒中患者身体活动改善就一定预后良好吗?

一半以上的采用改良的Rankin量表确定的功能恢复良好的脑卒中患者,仍然有认知功能障碍和参与度受限,并且有三分之一的患者在2到3年后仍然有抑郁症状。目前在大多数卒中急性试验中对良好功能结局的定义集中在活动有没有受到限制,但需要更多的关注多层次的恢复。