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ARCH PATHOL LAB MED：上皮样恶性间皮瘤伴胸肺转移的鉴别诊断

2020-05-21 MedSci原创 MedSci原创

原发性肺癌；乳腺癌；胸膜间皮瘤；转移
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胸膜间皮瘤是一种罕见的癌症类型，因为其与许多其他肿瘤具有非常相似的特征，所以诊断起来往往比较困难。其中，原发性肺癌和乳腺癌是导致胸膜间皮瘤转移的2大主要原因。

胸膜间皮瘤是一种罕见的癌症类型，因为其与许多其他肿瘤具有非常相似的特征，所以诊断起来往往比较困难。其中，原发性肺癌和乳腺癌是导致胸膜间皮瘤转移的2大主要原因。而随着靶向治疗药物的发展和应用，对其进行准确诊断变得更为重要。在此背景下，国际指南推荐使用2种阳性和2种阴性免疫组织化学生物标记物。本研究的目的是确定用于分离肺和乳腺转移的上皮样恶性间皮瘤的最特异、最敏感的常规最低限度抗体，并确定表达截止值。

为了提供16种间皮和上皮生物标志物的不同表达水平的信息，研究人员对1979年至2017年期间发表的文章进行了系统的回顾，并将这些数据与1998年以来在常规实践数据库中使用的标准化小组的间皮瘤远程病理网络(MESOPATH)的结果进行了比较。

结果表明，应推荐以下标志物：钙网蛋白（聚）/甲状腺转录因子1（TTF-1；克隆8G7G3 / 1）和钙卫蛋白（聚）/雌激素受体-α（ER-α；克隆EP1）作为诊断标志； 最终，基于MESOPATH数据库，研究人员强调了它们的相关性，这是在10％截止值时对鉴别诊断有用的最敏感和最特定组合。

研究结果表明，基于其在大样本研究中的相关性，研究人员推荐2个有用的诊断组合，其诊断下限为10%。

原始出处：

Nolwenn Le Stang, MSc; Louise Burke, MD;Differential Diagnosis of Epithelioid Malignant Mesothelioma With Lung and Breast Pleural Metastasis: A Systematic Review Compared With a Standardized Panel of Antibodies—A New Proposal That May Influence Pathologic

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    2021-05-04 yilong5287551

    #恶性间皮瘤#

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    2020-06-06 yb6560

    #Pathol#

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    2020-05-22 Homburg

    #鉴别诊断#

    0

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    2020-05-22 licz0428

    #肺转移#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1668546, encodeId=0dc11668546f9, content=<a href='/topic/show?id=5b0f5296033' target=_blank style='color:#2F92EE;'>#恶性间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52960, encryptionId=5b0f5296033, topicName=恶性间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1526340063, createdName=yilong5287551, createdTime=Tue May 04 10:50:04 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786329, encodeId=967d1e8632944, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sat Jun 06 11:50:04 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506957, encodeId=3d78150695e2b, content=<a href='/topic/show?id=a66b9624e0c' target=_blank style='color:#2F92EE;'>#鉴别诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96247, encryptionId=a66b9624e0c, topicName=鉴别诊断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77179846395, createdName=Homburg, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555530, encodeId=34aa1555530d0, content=<a href='/topic/show?id=6d4f8232623' target=_blank style='color:#2F92EE;'>#肺转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82326, encryptionId=6d4f8232623, topicName=肺转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6914619384, createdName=licz0428, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579815, encodeId=a96915e981577, content=<a href='/topic/show?id=6db59e28738' target=_blank style='color:#2F92EE;'>#间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97287, encryptionId=6db59e28738, topicName=间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61a16562641, createdName=1249884fm92暂无昵称, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603262, encodeId=dc01160326251, content=<a href='/topic/show?id=c9ee2002218' target=_blank style='color:#2F92EE;'>#上皮样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20022, encryptionId=c9ee2002218, topicName=上皮样)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c9e19008088, createdName=qblt, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610491, encodeId=f5f81610491c1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=469141, encodeId=f36f46914143, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210706/5924e86cc73c43efb5bad9dd92ac0d7b/63609a5527c447f48b59b39dd248a66f.jpg, createdBy=cf0a5102349, createdName=站在塔尖, createdTime=Thu May 21 22:39:46 CST 2020, time=2020-05-21, status=1, ipAttribution=)]
    2020-05-22 1249884fm92暂无昵称

    #间皮瘤#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1668546, encodeId=0dc11668546f9, content=<a href='/topic/show?id=5b0f5296033' target=_blank style='color:#2F92EE;'>#恶性间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52960, encryptionId=5b0f5296033, topicName=恶性间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1526340063, createdName=yilong5287551, createdTime=Tue May 04 10:50:04 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786329, encodeId=967d1e8632944, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sat Jun 06 11:50:04 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506957, encodeId=3d78150695e2b, content=<a href='/topic/show?id=a66b9624e0c' target=_blank style='color:#2F92EE;'>#鉴别诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96247, encryptionId=a66b9624e0c, topicName=鉴别诊断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77179846395, createdName=Homburg, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555530, encodeId=34aa1555530d0, content=<a href='/topic/show?id=6d4f8232623' target=_blank style='color:#2F92EE;'>#肺转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82326, encryptionId=6d4f8232623, topicName=肺转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6914619384, createdName=licz0428, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579815, encodeId=a96915e981577, content=<a href='/topic/show?id=6db59e28738' target=_blank style='color:#2F92EE;'>#间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97287, encryptionId=6db59e28738, topicName=间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61a16562641, createdName=1249884fm92暂无昵称, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603262, encodeId=dc01160326251, content=<a href='/topic/show?id=c9ee2002218' target=_blank style='color:#2F92EE;'>#上皮样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20022, encryptionId=c9ee2002218, topicName=上皮样)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c9e19008088, createdName=qblt, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610491, encodeId=f5f81610491c1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=469141, encodeId=f36f46914143, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210706/5924e86cc73c43efb5bad9dd92ac0d7b/63609a5527c447f48b59b39dd248a66f.jpg, createdBy=cf0a5102349, createdName=站在塔尖, createdTime=Thu May 21 22:39:46 CST 2020, time=2020-05-21, status=1, ipAttribution=)]
    2020-05-22 qblt

    #上皮样#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1668546, encodeId=0dc11668546f9, content=<a href='/topic/show?id=5b0f5296033' target=_blank style='color:#2F92EE;'>#恶性间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52960, encryptionId=5b0f5296033, topicName=恶性间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1526340063, createdName=yilong5287551, createdTime=Tue May 04 10:50:04 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786329, encodeId=967d1e8632944, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sat Jun 06 11:50:04 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506957, encodeId=3d78150695e2b, content=<a href='/topic/show?id=a66b9624e0c' target=_blank style='color:#2F92EE;'>#鉴别诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96247, encryptionId=a66b9624e0c, topicName=鉴别诊断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77179846395, createdName=Homburg, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555530, encodeId=34aa1555530d0, content=<a href='/topic/show?id=6d4f8232623' target=_blank style='color:#2F92EE;'>#肺转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82326, encryptionId=6d4f8232623, topicName=肺转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6914619384, createdName=licz0428, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579815, encodeId=a96915e981577, content=<a href='/topic/show?id=6db59e28738' target=_blank style='color:#2F92EE;'>#间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97287, encryptionId=6db59e28738, topicName=间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61a16562641, createdName=1249884fm92暂无昵称, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603262, encodeId=dc01160326251, content=<a href='/topic/show?id=c9ee2002218' target=_blank style='color:#2F92EE;'>#上皮样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20022, encryptionId=c9ee2002218, topicName=上皮样)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c9e19008088, createdName=qblt, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610491, encodeId=f5f81610491c1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=469141, encodeId=f36f46914143, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210706/5924e86cc73c43efb5bad9dd92ac0d7b/63609a5527c447f48b59b39dd248a66f.jpg, createdBy=cf0a5102349, createdName=站在塔尖, createdTime=Thu May 21 22:39:46 CST 2020, time=2020-05-21, status=1, ipAttribution=)]
    2020-05-22 智慧医人

    #Med#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1668546, encodeId=0dc11668546f9, content=<a href='/topic/show?id=5b0f5296033' target=_blank style='color:#2F92EE;'>#恶性间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52960, encryptionId=5b0f5296033, topicName=恶性间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1526340063, createdName=yilong5287551, createdTime=Tue May 04 10:50:04 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786329, encodeId=967d1e8632944, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sat Jun 06 11:50:04 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506957, encodeId=3d78150695e2b, content=<a href='/topic/show?id=a66b9624e0c' target=_blank style='color:#2F92EE;'>#鉴别诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96247, encryptionId=a66b9624e0c, topicName=鉴别诊断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77179846395, createdName=Homburg, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555530, encodeId=34aa1555530d0, content=<a href='/topic/show?id=6d4f8232623' target=_blank style='color:#2F92EE;'>#肺转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82326, encryptionId=6d4f8232623, topicName=肺转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6914619384, createdName=licz0428, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579815, encodeId=a96915e981577, content=<a href='/topic/show?id=6db59e28738' target=_blank style='color:#2F92EE;'>#间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97287, encryptionId=6db59e28738, topicName=间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61a16562641, createdName=1249884fm92暂无昵称, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603262, encodeId=dc01160326251, content=<a href='/topic/show?id=c9ee2002218' target=_blank style='color:#2F92EE;'>#上皮样#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20022, encryptionId=c9ee2002218, topicName=上皮样)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c9e19008088, createdName=qblt, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610491, encodeId=f5f81610491c1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri May 22 23:50:04 CST 2020, time=2020-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=469141, encodeId=f36f46914143, content=哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210706/5924e86cc73c43efb5bad9dd92ac0d7b/63609a5527c447f48b59b39dd248a66f.jpg, createdBy=cf0a5102349, createdName=站在塔尖, createdTime=Thu May 21 22:39:46 CST 2020, time=2020-05-21, status=1, ipAttribution=)]
    2020-05-21 站在塔尖

    哈哈

    0