Nature Metabolism:运动的好处因人而异,原来是血浆蛋白惹的祸!

2021-05-29 MedSci原创 MedSci原创

众所周知,生命在于运动,想要保持健康必要的运动不可少。运动不仅仅能够减肥,还能够改善睡眠,缓解压力,提升心情,以及强化骨骼和肌肉等。

众所周知,生命在于运动,想要保持健康必要的运动不可少。运动不仅仅能够减肥,还能够改善睡眠,缓解压力,提升心情,以及强化骨骼和肌肉等。虽然运动的好处人尽皆知,但同样的运动对不同的人产生的效果有可能也不同。

为了揭示运动对身体的影响以及个体之间的差异,研究人员对650 名久坐不动的成年人进行为期20周的运动计划,在运动前后分别测定了参与者的血液中大约5,000种血浆蛋白,并确定了147种蛋白和102种血浆蛋白水平分别与基线最大摄氧量和最大摄氧的增加有关。研究结果发表在Nature Metabolism杂志上。

研究人员发现,骨骼、肌肉和血管蛋白质,与心肺健康有着密切联系。同时,研究小组开发一种蛋白质评分,提高了对个体最大摄氧量变化的预测能力。

同时,研究人员在基于一项社区队列研究中进行验证,进一步将蛋白质与基于社区的队列中的事件全因死亡率联系起来,发现多数蛋白与早逝风险升高有关,突出了心肺健康与对长期健康的影响。

研究人员表示,我们现在有一份新的血液化合物的详细清单,可以进一步了解运动对健康产生的影响,并预测不同运动方案对个体产生的作用。虽然没有任何药物能够概括运动带来的多种益处,但我们的研究帮助制定了路线图,以进一步探索潜在的干预措施,并为将运动作为一种疗法进行个性化提供了重要的一步。未来,仍需要进行更多的研究,将研究结果扩展到更大的人群中,进一步完善运动前后不同血浆蛋白对健康的影响。

总之,该研究揭示了与心肺健康相关的生物学途径,并突出了生物标志物在识别人类运动反应方面的潜在价值。

原始出处

Jeremy M. Robbins et al, Human plasma proteomic profiles indicative of cardiorespiratory fitnessNature Metabolism (2021). DOI: 10.1038/s42255-021-00400-z

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    2022-05-11 guojianrong
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    2022-01-13 liye789132251
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    2021-08-16 一闲
  5. [GetPortalCommentsPageByObjectIdResponse(id=1926509, encodeId=974a192650940, content=<a href='/topic/show?id=891089221dc' target=_blank style='color:#2F92EE;'>#血浆蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89221, encryptionId=891089221dc, topicName=血浆蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Jun 04 20:21:13 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888303, encodeId=9ef71888303f4, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed May 11 15:21:13 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1885185, encodeId=96481885185b2, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Thu Jan 13 16:21:13 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896847, encodeId=e3d4189684e0e, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Aug 16 20:21:13 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977274, encodeId=b0329e7274f2, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=61aa2089201, createdName=face, createdTime=Sun Jun 27 12:27:16 CST 2021, time=2021-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577267, encodeId=32de15e7267ca, content=<a href='/topic/show?id=d86d1159e36' target=_blank style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Mon May 31 13:21:13 CST 2021, time=2021-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598117, encodeId=3145159811ec8, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Mon May 31 13:21:13 CST 2021, time=2021-05-31, status=1, ipAttribution=)]
    2021-06-27 face

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1926509, encodeId=974a192650940, content=<a href='/topic/show?id=891089221dc' target=_blank style='color:#2F92EE;'>#血浆蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89221, encryptionId=891089221dc, topicName=血浆蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Jun 04 20:21:13 CST 2021, time=2021-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888303, encodeId=9ef71888303f4, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed May 11 15:21:13 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1885185, encodeId=96481885185b2, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Thu Jan 13 16:21:13 CST 2022, time=2022-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896847, encodeId=e3d4189684e0e, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Aug 16 20:21:13 CST 2021, time=2021-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977274, encodeId=b0329e7274f2, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=61aa2089201, createdName=face, createdTime=Sun Jun 27 12:27:16 CST 2021, time=2021-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577267, encodeId=32de15e7267ca, content=<a href='/topic/show?id=d86d1159e36' target=_blank style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Mon May 31 13:21:13 CST 2021, time=2021-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1598117, encodeId=3145159811ec8, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Mon May 31 13:21:13 CST 2021, time=2021-05-31, status=1, ipAttribution=)]
    2021-05-31 闆锋旦

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