JCI：可促癌症转移的特殊胶原交联结构

2015-02-13 佚名生物谷

当摩天大楼基本架构形成之后承包商们就会依据大楼结构来添加钢梁和支架，然而癌细胞也可以利用这种方式来生长，其会利用一种生物学基质来实现繁殖和扩散；近日一篇发表在国际杂志Journal of Clinical Investigation上的研究论文中，来自得克萨斯大学MD癌症研究中心的研究人员通过研究发现一种名为胶原交联结构的人类细胞支架，其可以决定肿瘤的生长及扩散能力，这种蛋白复合物的交联结构可

当摩天大楼基本架构形成之后承包商们就会依据大楼结构来添加钢梁和支架，然而癌细胞也可以利用这种方式来生长，其会利用一种生物学基质来实现繁殖和扩散；近日一篇发表在国际杂志Journal of Clinical Investigation上的研究论文中，来自得克萨斯大学MD癌症研究中心的研究人员通过研究发现一种名为胶原交联结构的人类细胞支架，其可以决定肿瘤的生长及扩散能力，这种蛋白复合物的交联结构可以使得结缔组织（细胞子座）更加牢固，从而促进肿瘤细胞的迁移。

胶原是一种最常见的支架蛋白，其主要负责组织力量的发挥，胶原代谢的多个方面在上皮组织衍生的癌症中并不会发挥正常功能；文章中研究者对小鼠和人类肺癌标本中的两种胶原交联结构进行了研究，包括HLCC（羟赖氨酸醛衍生的胶原交联结构）和LCC（赖氨酸醛衍生的胶原交联结构），结果发现HLCCs在骨骼组织中最为常见，而LCCs则通常出现在软组织中。

研究者Jonathan Kurie表示，我们发现，肿瘤的子座往往存在高水平的HLCC及低水平的LCC，而肿瘤细胞中赖氨酸羟化酶2的表达会增加肿瘤子座中HLCC向LCC过渡的比率，同时也会增强肿瘤的坚硬程度进而促进癌症转移，相关研究表明癌症组织中的胶原交联结构在调节肿瘤基质的硬度以及确定肿瘤细胞转移的命运中扮演着重要的角色。

由于赖氨酸羟化酶2可以增强肿瘤细胞转移的能力，因此其或许可作为一种调节性的开关，来控制肿瘤子座中不同类型胶原交联结构的相对丰度，从而为开发特殊的靶向疗法提供一定的帮助；本文研究首次在肿瘤子座中发现了胶原交联结构的存在，研究者表示，这种对于肿瘤细胞扩散非常重要的胶原交联结构的发现或许为后期开发治疗癌症以及抑制癌细胞扩散的新型疗法提供一定的希望和帮助。

原始出处

Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM.Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma.J Clin Invest. 2015 Feb 9

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2015-06-04 caobinglei8079

#JCI#

23 0
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2015-09-18 changhe722

#促癌#

29 0
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2015-05-16 ljjj1053

很不错很不错

106 0
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2015-02-21 orthoW

很不错

107 0
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2015-02-21 orthoW

非常好的文章，学习

97 0
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2015-02-16 windmilL1989

赞

110 0
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2015-02-15 xirongguo

#癌症转移#

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