Diabetes Care:卵巢切除不能减少女性糖尿病患者心血管疾病风险

2015-10-24 MedSci MedSci原创

有研究表明糖尿病会增加心血管疾病风险,并且该相关性在女性患者身上提现的更淋漓尽致。2型糖尿病的女性患者之所以心血管疾病风险高,有部分原因也归咎于卵巢雄激素产生增多。研究者进行了一项研究探究2型糖尿病女性行了双侧输卵管卵巢切除术,能都降低心血管疾病相关死亡率。该研究纳入了7977名 ≥65 岁的女性,其中有564患者检测了性激素相关的固醇激素。研究结果显示,研究对象的平均年龄为71.5岁,其中有6.

有研究表明糖尿病会增加心血管疾病风险,并且该相关性在女性患者身上提现的更淋漓尽致。2型糖尿病的女性患者之所以心血管疾病风险高,有部分原因也归咎于卵巢雄激素产生增多。研究者进行了一项研究探究2型糖尿病女性行了双侧输卵管卵巢切除术,能都降低心血管疾病相关死亡率。

该研究纳入了7977名 ≥65 岁的女性,其中有564患者检测了性激素相关的固醇激素。

研究结果显示,研究对象的平均年龄为71.5岁,其中有6.3%的患者有糖尿病,18%的患者切除了双侧输卵管卵巢。在564名检测了性激素水平的人群中,2型糖尿病患者游离睾酮比对照高出43.6%,该现象的出现可能与参与者年龄和肥胖等因素有关,研究者还发现,输卵管卵巢切除的女性与对照相比,期体内总睾酮和游离睾酮水平均较低。

在2型糖尿病患者中,没有切除了输卵管卵巢的女性其死于心血管疾病的风险(HR 1.95, 95% CI 1.62–2.35)比切除了该器官的女性高(HR 2.56, 95% CI 1.79–3.65)(P = 0.190)。同时输卵管卵巢切除术本身不会增加心血管疾病死亡率(HR 1.05, 95% CI 0.89–1.23)。

研究结果表明,女性糖尿病患者并不会因为其切除了输卵管卵巢,患心血管疾病的风险就会下降。卵巢分泌雄激素过多可能并不能充分解释2型糖尿病女性心血管疾病风险高的实事实。

原始出处:

Duke Appiah, Stephen J. Winters,et al.Androgens, Bilateral Oophorectomy, and Cardiovascular Disease Mortality in Postmenopausal Women With and Without Diabetes: The Study of Osteoporotic Fractures .Diabetes Care. October 12, 2015.

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  5. 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channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/26/5e1df344d663496bdfd43c465d409e2c.jpg, createdBy=bce679058, createdName=sunlong28, createdTime=Sat Oct 24 22:57:00 CST 2015, time=2015-10-24, status=1, ipAttribution=)]
  6. 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  7. 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channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/26/5e1df344d663496bdfd43c465d409e2c.jpg, createdBy=bce679058, createdName=sunlong28, createdTime=Sat Oct 24 22:57:00 CST 2015, time=2015-10-24, status=1, ipAttribution=)]
    2015-10-25 Troubleisme

    好好的卵巢还是别切了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1759598, encodeId=a7cd1e595986f, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Feb 12 09:43:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637182, encodeId=9dab163e1821c, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Mon Oct 26 01:43:00 CST 2015, time=2015-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41001, encodeId=d09b41001a1, content=好好的卵巢还是别切了, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151025/IMG562C3D4B3EFBE1123.jpg, createdBy=05d41658943, createdName=Troubleisme, createdTime=Sun Oct 25 10:37:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40999, encodeId=01a640999c0, content=我去, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151025/IMG562C3D4B3EFBE1123.jpg, createdBy=05d41658943, createdName=Troubleisme, createdTime=Sun Oct 25 10:36:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41000, encodeId=3ffb410004b, content=糖尿病, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151025/IMG562C3D4B3EFBE1123.jpg, createdBy=05d41658943, createdName=Troubleisme, createdTime=Sun Oct 25 10:36:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40794, encodeId=1de540e9422, content=非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/26/5e1df344d663496bdfd43c465d409e2c.jpg, createdBy=bce679058, createdName=sunlong28, createdTime=Sat Oct 24 22:57:00 CST 2015, time=2015-10-24, status=1, ipAttribution=)]
    2015-10-25 Troubleisme

    我去

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1759598, encodeId=a7cd1e595986f, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Feb 12 09:43:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637182, encodeId=9dab163e1821c, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, 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objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151025/IMG562C3D4B3EFBE1123.jpg, createdBy=05d41658943, createdName=Troubleisme, createdTime=Sun Oct 25 10:36:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41000, encodeId=3ffb410004b, content=糖尿病, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151025/IMG562C3D4B3EFBE1123.jpg, createdBy=05d41658943, createdName=Troubleisme, createdTime=Sun Oct 25 10:36:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40794, encodeId=1de540e9422, content=非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/26/5e1df344d663496bdfd43c465d409e2c.jpg, createdBy=bce679058, createdName=sunlong28, createdTime=Sat Oct 24 22:57:00 CST 2015, time=2015-10-24, status=1, ipAttribution=)]
    2015-10-25 Troubleisme

    糖尿病

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151025/IMG562C3D4B3EFBE1123.jpg, createdBy=05d41658943, createdName=Troubleisme, createdTime=Sun Oct 25 10:36:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41000, encodeId=3ffb410004b, content=糖尿病, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151025/IMG562C3D4B3EFBE1123.jpg, createdBy=05d41658943, createdName=Troubleisme, createdTime=Sun Oct 25 10:36:00 CST 2015, time=2015-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=40794, encodeId=1de540e9422, content=非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/05/26/5e1df344d663496bdfd43c465d409e2c.jpg, createdBy=bce679058, createdName=sunlong28, createdTime=Sat Oct 24 22:57:00 CST 2015, time=2015-10-24, status=1, ipAttribution=)]
    2015-10-24 sunlong28

    非常感谢

    0

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