氨溴索的使用细节,必须注意!

2016-11-08 华武星 医学界呼吸频道

氨溴索是一种祛痰剂,是溴己新的衍生物,是溴己新在体内的活性代谢产物,作用较溴己新更强,且毒性小,耐受性好。氨溴索能促进肺表面活性物质的分泌及气道液体分泌,使得痰液中的粘多糖蛋白纤维断裂,促进粘痰溶解,显着降低痰粘度,增强支气管黏膜纤毛运动,促进痰液排出,改善通气功能和呼吸困难状况。正是这些优点让氨溴索成为应用最为广泛的祛痰剂。1、氨溴索的使用方法氨溴索有片剂、口服溶液剂、注射液等多种剂型,使用方便

氨溴索是一种祛痰剂,是溴己新的衍生物,是溴己新在体内的活性代谢产物,作用较溴己新更强,且毒性小,耐受性好。氨溴索能促进肺表面活性物质的分泌及气道液体分泌,使得痰液中的粘多糖蛋白纤维断裂,促进粘痰溶解,显着降低痰粘度,增强支气管黏膜纤毛运动,促进痰液排出,改善通气功能和呼吸困难状况。正是这些优点让氨溴索成为应用最为广泛的祛痰剂。

1、氨溴索的使用方法

氨溴索有片剂、口服溶液剂、注射液等多种剂型,使用方便。口服后1小时内生效,作用可持续3~6小时。呼吸科患者(成人及12岁以上儿童)常用口服剂量为30~60 mg/次,tid.患者口服不方便时可通过静脉给药,一般可静脉点滴,如果不想补液量过大,则可通过静脉注射给药。一次剂量可为15~30 mg,tid,严重病例可增加剂量,比如治疗卧床吸入性肺炎时可酌情增加剂量,当然最好配合着吸痰用。临床上有些医生使用氨溴索的剂量高达120 mg,bid;或者150 mg,qd;或者300 mg,bid等,甚至更大剂量使用,需知道药品说明书并未提及可使用这么大的剂量,在超说明书用药时应与患者充分解释病情。
 
至于氨溴索是否可以雾化吸入,一直以来都有争议,虽然药品说明书并没有提及雾化吸入,但临床上很多人都在用,而且据报道疗效不错,雾化吸入的话多用进口的氨溴索(商品名:沐舒坦),再一次强调,药品说明书并没有说明可雾化吸入给药,如果出事就糟糕,本文作者所在单位很少使用雾化吸入氨溴索。

2、氨溴索具体应用细节

作为一种高效的祛痰剂,氨溴索广泛应用,临床疗效也确实不错。呼吸科最常见的住院病人是慢阻肺急性加重、肺部感染等,这些病人接受氨溴索等祛痰剂治疗是必要的。但稳定期慢阻肺患者常规使用氨溴索就不一定有效了,虽然慢阻肺患者稳定期仍有可能咳大量黏痰,且应用祛痰药似乎能够改善气道引流,改善通气,但目前的研究证据认为总体疗效不十分确切。稳定期慢阻肺仍应以吸入长效支气管扩张剂为主,祛痰剂可能只扮演小喽啰的角色。
 
需要使用氨溴索的患者,往往都伴有感染,而这部分患者当然也在使用抗菌药物。而氨溴索与阿莫西林、阿莫西林/克拉维酸、氨苄西林、头孢呋辛、红霉素等抗生素联用时,可增加这些抗生素在肺内的分布浓度,从而增强其抗菌疗效。  而慢阻肺急性加重等患者的突出临床表现是气促,常需要使用诸如沙丁胺醇、异丙托溴铵、茶碱等平喘药,而氨溴索与这些药物合用时也能起到协同作用。
 
打个比方,平喘药是人为地扩大管道(支气管)口径,而祛痰剂则是清理管道里面的垃圾,两者均能起到通畅管道、加强通流的作用,而且相辅相成。另外,氨溴索尚可用于婴儿呼吸窘迫综合征的治疗,这时候的剂量一般较大。
 
氨溴索的不良反应轻微且少,仅有少数患者可能出现轻微的胃肠道反应,偶见皮疹,而且患者可能同时使用多种药物,有时不好分辨不良反应到底来自哪个药物。总的来说,氨溴索是很安全的,不管是口服还是注射。

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    2016-11-24 杨柳青青

    咨询很好~可是更新太慢了

    0

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    2016-11-23 杨柳青青

    咨询更新的很慢啊

    0

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    2016-11-10 1dedfe95m66(暂无匿称)

    学习再学习

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=157778, encodeId=b6bf15e7783e, content=咨询很好~可是更新太慢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Nov 24 06:48:50 CST 2016, time=2016-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157613, encodeId=dcca15e61388, content=咨询更新的很慢啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Wed Nov 23 12:34:15 CST 2016, time=2016-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154785, encodeId=a203154e8519, content=学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ff901728138, createdName=1dedfe95m66(暂无匿称), createdTime=Thu Nov 10 14:32:52 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459830, encodeId=3c7914598302a, content=<a href='/topic/show?id=e8786405468' target=_blank style='color:#2F92EE;'>#氨溴索#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64054, encryptionId=e8786405468, topicName=氨溴索)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d48c6200059, createdName=chentianping, createdTime=Thu Nov 10 08:26:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154664, encodeId=ba0715466450, content=学习了,谢谢分享,不过没见特别注意事项, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e0c1940872, createdName=1e0ef473m06(暂无匿称), createdTime=Thu Nov 10 00:04:42 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154522, encodeId=ec4e15452210, content=是的,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1104997918/231D86F03CD9EE07FB0C75BDC037C1E0/100, createdBy=2aa71721540, createdName=QQe072d2fb, createdTime=Wed Nov 09 09:21:19 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154499, encodeId=daf315449906, content=没有说要注意安全什么的,倒是全是好的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Wed Nov 09 07:50:34 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154449, encodeId=5999154449a2, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Wed Nov 09 06:08:52 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154412, encodeId=33b915441276, content=学习了,棒棒哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUxfqEBLTrFZvMCToegPxv4CovnkibcroaO2d41HROFgTh9Acnhia4m6BiaRwLMpm8tC9yticL9WQ2lQ/132, createdBy=428e1975226, createdName=小靖儿, createdTime=Tue Nov 08 22:48:23 CST 2016, time=2016-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154401, encodeId=f66f15440192, content=细节呢?标题比较诱人,内容信息度不多, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKDtuWHtWxToIW0ZEvbHgDb4ibqQ1xaDQxcsHC5NIc2RJUxQgHJOLGEg8OUT345rDPmka4icU0WHPgw/0, createdBy=379f1941464, createdName=艳阳天2016, createdTime=Tue Nov 08 21:18:50 CST 2016, time=2016-11-08, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=157778, encodeId=b6bf15e7783e, content=咨询很好~可是更新太慢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Nov 24 06:48:50 CST 2016, time=2016-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157613, encodeId=dcca15e61388, content=咨询更新的很慢啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Wed Nov 23 12:34:15 CST 2016, time=2016-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154785, encodeId=a203154e8519, content=学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ff901728138, createdName=1dedfe95m66(暂无匿称), createdTime=Thu Nov 10 14:32:52 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459830, encodeId=3c7914598302a, content=<a href='/topic/show?id=e8786405468' target=_blank style='color:#2F92EE;'>#氨溴索#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64054, encryptionId=e8786405468, topicName=氨溴索)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d48c6200059, createdName=chentianping, createdTime=Thu Nov 10 08:26:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154664, encodeId=ba0715466450, content=学习了,谢谢分享,不过没见特别注意事项, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e0c1940872, createdName=1e0ef473m06(暂无匿称), createdTime=Thu Nov 10 00:04:42 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154522, encodeId=ec4e15452210, content=是的,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1104997918/231D86F03CD9EE07FB0C75BDC037C1E0/100, createdBy=2aa71721540, createdName=QQe072d2fb, createdTime=Wed Nov 09 09:21:19 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154499, encodeId=daf315449906, content=没有说要注意安全什么的,倒是全是好的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Wed Nov 09 07:50:34 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154449, encodeId=5999154449a2, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Wed Nov 09 06:08:52 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154412, encodeId=33b915441276, content=学习了,棒棒哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUxfqEBLTrFZvMCToegPxv4CovnkibcroaO2d41HROFgTh9Acnhia4m6BiaRwLMpm8tC9yticL9WQ2lQ/132, createdBy=428e1975226, createdName=小靖儿, createdTime=Tue Nov 08 22:48:23 CST 2016, time=2016-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154401, encodeId=f66f15440192, content=细节呢?标题比较诱人,内容信息度不多, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKDtuWHtWxToIW0ZEvbHgDb4ibqQ1xaDQxcsHC5NIc2RJUxQgHJOLGEg8OUT345rDPmka4icU0WHPgw/0, createdBy=379f1941464, createdName=艳阳天2016, createdTime=Tue Nov 08 21:18:50 CST 2016, time=2016-11-08, status=1, ipAttribution=)]
    2016-11-10 1e0ef473m06(暂无匿称)

    学习了,谢谢分享,不过没见特别注意事项

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=157778, encodeId=b6bf15e7783e, content=咨询很好~可是更新太慢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Nov 24 06:48:50 CST 2016, time=2016-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157613, encodeId=dcca15e61388, content=咨询更新的很慢啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Wed Nov 23 12:34:15 CST 2016, time=2016-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154785, encodeId=a203154e8519, content=学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ff901728138, createdName=1dedfe95m66(暂无匿称), createdTime=Thu Nov 10 14:32:52 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459830, encodeId=3c7914598302a, content=<a href='/topic/show?id=e8786405468' target=_blank style='color:#2F92EE;'>#氨溴索#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64054, encryptionId=e8786405468, topicName=氨溴索)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d48c6200059, createdName=chentianping, createdTime=Thu Nov 10 08:26:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154664, encodeId=ba0715466450, content=学习了,谢谢分享,不过没见特别注意事项, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e0c1940872, createdName=1e0ef473m06(暂无匿称), createdTime=Thu Nov 10 00:04:42 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154522, encodeId=ec4e15452210, content=是的,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1104997918/231D86F03CD9EE07FB0C75BDC037C1E0/100, createdBy=2aa71721540, createdName=QQe072d2fb, createdTime=Wed Nov 09 09:21:19 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154499, encodeId=daf315449906, content=没有说要注意安全什么的,倒是全是好的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Wed Nov 09 07:50:34 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154449, encodeId=5999154449a2, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Wed Nov 09 06:08:52 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154412, encodeId=33b915441276, content=学习了,棒棒哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUxfqEBLTrFZvMCToegPxv4CovnkibcroaO2d41HROFgTh9Acnhia4m6BiaRwLMpm8tC9yticL9WQ2lQ/132, createdBy=428e1975226, createdName=小靖儿, createdTime=Tue Nov 08 22:48:23 CST 2016, time=2016-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154401, encodeId=f66f15440192, content=细节呢?标题比较诱人,内容信息度不多, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKDtuWHtWxToIW0ZEvbHgDb4ibqQ1xaDQxcsHC5NIc2RJUxQgHJOLGEg8OUT345rDPmka4icU0WHPgw/0, createdBy=379f1941464, createdName=艳阳天2016, createdTime=Tue Nov 08 21:18:50 CST 2016, time=2016-11-08, status=1, ipAttribution=)]
    2016-11-09 QQe072d2fb

    是的,学习了

    0

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    2016-11-09 医张生

    没有说要注意安全什么的,倒是全是好的。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=157778, encodeId=b6bf15e7783e, content=咨询很好~可是更新太慢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Nov 24 06:48:50 CST 2016, time=2016-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157613, encodeId=dcca15e61388, content=咨询更新的很慢啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Wed Nov 23 12:34:15 CST 2016, time=2016-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154785, encodeId=a203154e8519, content=学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ff901728138, createdName=1dedfe95m66(暂无匿称), createdTime=Thu Nov 10 14:32:52 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459830, encodeId=3c7914598302a, content=<a href='/topic/show?id=e8786405468' target=_blank style='color:#2F92EE;'>#氨溴索#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64054, encryptionId=e8786405468, topicName=氨溴索)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d48c6200059, createdName=chentianping, createdTime=Thu Nov 10 08:26:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154664, encodeId=ba0715466450, content=学习了,谢谢分享,不过没见特别注意事项, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e0c1940872, createdName=1e0ef473m06(暂无匿称), createdTime=Thu Nov 10 00:04:42 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154522, encodeId=ec4e15452210, content=是的,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1104997918/231D86F03CD9EE07FB0C75BDC037C1E0/100, createdBy=2aa71721540, createdName=QQe072d2fb, createdTime=Wed Nov 09 09:21:19 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154499, encodeId=daf315449906, content=没有说要注意安全什么的,倒是全是好的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Wed Nov 09 07:50:34 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154449, encodeId=5999154449a2, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Wed Nov 09 06:08:52 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154412, encodeId=33b915441276, content=学习了,棒棒哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUxfqEBLTrFZvMCToegPxv4CovnkibcroaO2d41HROFgTh9Acnhia4m6BiaRwLMpm8tC9yticL9WQ2lQ/132, createdBy=428e1975226, createdName=小靖儿, createdTime=Tue Nov 08 22:48:23 CST 2016, time=2016-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154401, encodeId=f66f15440192, content=细节呢?标题比较诱人,内容信息度不多, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKDtuWHtWxToIW0ZEvbHgDb4ibqQ1xaDQxcsHC5NIc2RJUxQgHJOLGEg8OUT345rDPmka4icU0WHPgw/0, createdBy=379f1941464, createdName=艳阳天2016, createdTime=Tue Nov 08 21:18:50 CST 2016, time=2016-11-08, status=1, ipAttribution=)]
    2016-11-09 半夏微凉

    谢谢分享!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=157778, encodeId=b6bf15e7783e, content=咨询很好~可是更新太慢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Nov 24 06:48:50 CST 2016, time=2016-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157613, encodeId=dcca15e61388, content=咨询更新的很慢啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Wed Nov 23 12:34:15 CST 2016, time=2016-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154785, encodeId=a203154e8519, content=学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ff901728138, createdName=1dedfe95m66(暂无匿称), createdTime=Thu Nov 10 14:32:52 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459830, encodeId=3c7914598302a, content=<a href='/topic/show?id=e8786405468' target=_blank style='color:#2F92EE;'>#氨溴索#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64054, encryptionId=e8786405468, topicName=氨溴索)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d48c6200059, createdName=chentianping, createdTime=Thu Nov 10 08:26:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154664, encodeId=ba0715466450, content=学习了,谢谢分享,不过没见特别注意事项, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e0c1940872, createdName=1e0ef473m06(暂无匿称), createdTime=Thu Nov 10 00:04:42 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154522, encodeId=ec4e15452210, content=是的,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1104997918/231D86F03CD9EE07FB0C75BDC037C1E0/100, createdBy=2aa71721540, createdName=QQe072d2fb, createdTime=Wed Nov 09 09:21:19 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154499, encodeId=daf315449906, content=没有说要注意安全什么的,倒是全是好的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Wed Nov 09 07:50:34 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154449, encodeId=5999154449a2, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Wed Nov 09 06:08:52 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154412, encodeId=33b915441276, content=学习了,棒棒哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUxfqEBLTrFZvMCToegPxv4CovnkibcroaO2d41HROFgTh9Acnhia4m6BiaRwLMpm8tC9yticL9WQ2lQ/132, createdBy=428e1975226, createdName=小靖儿, createdTime=Tue Nov 08 22:48:23 CST 2016, time=2016-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154401, encodeId=f66f15440192, content=细节呢?标题比较诱人,内容信息度不多, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKDtuWHtWxToIW0ZEvbHgDb4ibqQ1xaDQxcsHC5NIc2RJUxQgHJOLGEg8OUT345rDPmka4icU0WHPgw/0, createdBy=379f1941464, createdName=艳阳天2016, createdTime=Tue Nov 08 21:18:50 CST 2016, time=2016-11-08, status=1, ipAttribution=)]
    2016-11-08 小靖儿

    学习了,棒棒哒

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=157778, encodeId=b6bf15e7783e, content=咨询很好~可是更新太慢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Thu Nov 24 06:48:50 CST 2016, time=2016-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=157613, encodeId=dcca15e61388, content=咨询更新的很慢啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eeef1960262, createdName=杨柳青青, createdTime=Wed Nov 23 12:34:15 CST 2016, time=2016-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154785, encodeId=a203154e8519, content=学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ff901728138, createdName=1dedfe95m66(暂无匿称), createdTime=Thu Nov 10 14:32:52 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459830, encodeId=3c7914598302a, content=<a href='/topic/show?id=e8786405468' target=_blank style='color:#2F92EE;'>#氨溴索#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64054, encryptionId=e8786405468, topicName=氨溴索)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d48c6200059, createdName=chentianping, createdTime=Thu Nov 10 08:26:00 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154664, encodeId=ba0715466450, content=学习了,谢谢分享,不过没见特别注意事项, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3e0c1940872, createdName=1e0ef473m06(暂无匿称), createdTime=Thu Nov 10 00:04:42 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154522, encodeId=ec4e15452210, content=是的,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1104997918/231D86F03CD9EE07FB0C75BDC037C1E0/100, createdBy=2aa71721540, createdName=QQe072d2fb, createdTime=Wed Nov 09 09:21:19 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154499, encodeId=daf315449906, content=没有说要注意安全什么的,倒是全是好的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Wed Nov 09 07:50:34 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154449, encodeId=5999154449a2, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Wed Nov 09 06:08:52 CST 2016, time=2016-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154412, encodeId=33b915441276, content=学习了,棒棒哒, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUxfqEBLTrFZvMCToegPxv4CovnkibcroaO2d41HROFgTh9Acnhia4m6BiaRwLMpm8tC9yticL9WQ2lQ/132, createdBy=428e1975226, createdName=小靖儿, createdTime=Tue Nov 08 22:48:23 CST 2016, time=2016-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154401, encodeId=f66f15440192, content=细节呢?标题比较诱人,内容信息度不多, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKDtuWHtWxToIW0ZEvbHgDb4ibqQ1xaDQxcsHC5NIc2RJUxQgHJOLGEg8OUT345rDPmka4icU0WHPgw/0, createdBy=379f1941464, createdName=艳阳天2016, createdTime=Tue Nov 08 21:18:50 CST 2016, time=2016-11-08, status=1, ipAttribution=)]
    2016-11-08 艳阳天2016

    细节呢?标题比较诱人,内容信息度不多

    0

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